Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028961 (oliguria)
 1,847 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Female Sprague-Dawley rats were sham operated, adrenal-enucleated, or mononephrectomized. Half of each group received 30 mg/kg of nitrendipine; the remainder were given equal volumes of vehicle, and all rats were then injected i.p. with 40 ml/kg of 0.9% NaCl solution. Urine was collected over a 6-h period. Nitrendipine-treated intact rats excreted slightly more water and Na+ and less K+ than controls, but none of the differences were significant statistically. Adrenal-enucleate controls displayed oliguria and Na+ retention, but normal K+ excretion and reduced Na+/K+. Nitrendipine did not modify oliguria or antinatriuresis or affect Na+/K+. Mononephrectomized rats behave similarly, but in these nitrendipine abolished oliguria and improved Na+ excretion. The most characteristic nitrendipine effect in all three cases was a reduction in urine osmolality. This was particularly evident in adrenal-enucleated and mononephrectomized rats, in which control urine displayed a relative hyperosmolarity as compared with normal control values.
 ...
PMID:Effect of nitrendipine on urine volume, osmolality, and electrolyte excretion in normal, adrenal-enucleate, and mononephrectomized rats. 608 61

Blood pressure was retrospectively studied in all 22 extremely low birth weight infants (ELBW) (birth weight median 720 g, range 450-1020 g) who were admitted between July 1989 and October 1991 and received dexamethasone on days 2-25 (median 10) because of bronchopulmonary dysplasia or since lung function had not improved after installation of bovine surfactant. The average blood pressure during the 4 h before dexamethasone increased significantly (median individual increase 8 mmHg, P = 0.0005) until 8-12h thereafter. In addition to the lung disease, ten infants showed severe arterial hypotension with prolonged capillary refilling time ( > 3s) and oliguria and needed continuous infusion of epinephrine to increase blood pressure and urinary flow after treatment with colloids, dopamine and dobutamine had proved ineffective. Epinephrine infusion could be stopped in eight infants 8 h after dexamethasone administration. In ELBW infants blood pressure rose 8-12 h after a single dose of 0.25 mg/kg dexamethasone. In ELBW infants suffering from arterial hypotension who do not respond to infusion of colloids and catecholamines, dexamethasone may represent a new therapeutic tool.
 ...
PMID:Rapid increase of blood pressure in extremely low birth weight infants after a single dose of dexamethasone. 819 71