Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028961 (oliguria)
 1,847 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Female Sprague-Dawley rats were sham operated, adrenal-enucleated, or mononephrectomized. Half of each group received 30 mg/kg of nitrendipine; the remainder were given equal volumes of vehicle, and all rats were then injected i.p. with 40 ml/kg of 0.9% NaCl solution. Urine was collected over a 6-h period. Nitrendipine-treated intact rats excreted slightly more water and Na+ and less K+ than controls, but none of the differences were significant statistically. Adrenal-enucleate controls displayed oliguria and Na+ retention, but normal K+ excretion and reduced Na+/K+. Nitrendipine did not modify oliguria or antinatriuresis or affect Na+/K+. Mononephrectomized rats behave similarly, but in these nitrendipine abolished oliguria and improved Na+ excretion. The most characteristic nitrendipine effect in all three cases was a reduction in urine osmolality. This was particularly evident in adrenal-enucleated and mononephrectomized rats, in which control urine displayed a relative hyperosmolarity as compared with normal control values.
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PMID:Effect of nitrendipine on urine volume, osmolality, and electrolyte excretion in normal, adrenal-enucleate, and mononephrectomized rats. 608 61