Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 27897
leptin 7858
Sep 7384
Mol 4374
gut 3642
adiponectin 3611
HDL 2358
cytokine 1945
Leptin 1712
adipokine 1424
glucagon 1417
IL-6 1352
TNF 1339
C-reactive protein 1291
tumor necrosis factor 1281
peroxisome proliferator-activated receptor 1199
ghrelin 1134
epididymal 1016
leptin receptor 993
uncoupling protein 1 914
endoplasmic reticulum 906
AMP-activated protein kinase 892
resistin 883
peroxisome proliferator-activated receptor gamma 880
renin 870
ATP 834
growth hormone 817
Adiponectin 803
insulin receptor 799
hemoglobin 771
interleukin-6 766
neuropeptide Y 689
AMPK 644
mTOR 615
beta-endorphin 611
fatty acid synthase 587
IRS-1 584
lipoprotein lipase 544
lipopolysaccharide 528
PPAR 523
collagen 497
albumin 477
lipase 474
ACTH 472
plasminogen activator inhibitor-1 439
uncoupling protein 419
FTO 396
fibrinogen 394
MAPK 388
AKT 382
Men 374
GLUT4 371
PI3K 368
insulin-like growth factor 368
cholecystokinin 365
MRI 365
alanine aminotransferase 365
TLR4 364
agouti 362
PGC 356
CRP 355
Pol 354
angiotensin II 353
visfatin 353
IL-10 350
STAT3 348
superoxide dismutase 343
Ghrelin 341
GLP-1 receptor 340
TNF-alpha 339
NIDDM 335
histone 329
proopiomelanocortin 322
GLP-1 320
CD36 320
hormone-sensitive lipase 319
aP2 319
peptide YY 319
glucose transporter 317
ANOVA 317
nuclear receptor 317
JNK 314
p38 311
prolactin 309
estrogen receptor 309
MCP-1 306
UCP2 303
She 294
acetyl-CoA carboxylase 281
AMP 273
ERK1 271
ERK 266
pancreatic lipase 263
MC4R 261
ART 258
catalase 258
aspartate aminotransferase 258
IGF-1 257
thyroid hormone 257
brain-derived neurotrophic factor 256
sex hormone-binding globulin 254
LPS 254
melanocortin-4 receptor 253
chemokine 252
orexin 250
tumor necrosis factor alpha 249
monocyte chemoattractant protein-1 249
IL-8 245
apolipoprotein B 240
IGF-I 240
CB1 236
Fibroblast growth factor 21 235
p53 234
vascular endothelial growth factor 233
perilipin 230
NMR 229
interferon 227
ROS 223
adipose triglyceride lipase 221
glucocorticoid receptor 215
SIRT1 213
HSD1 211
inducible nitric oxide synthase 209
aromatase 208
nitric oxide synthase 206
apolipoprotein 205
somatostatin 205
peptidase 203
caspase-3 203
amylase 202
San 201
FAS 200
NAD 200
Cytokine 199
protein kinase B 199
amylin 195
UCP3 195
melanin-concentrating hormone 193
plasminogen activator inhibitor 192
phosphatase 190
Resistin 188
CD4 187
SBP 186
G protein-coupled receptor 186
EBP 185
IL-1 184
GSH 182
phosphatidylinositol 3-kinase 181
glycoprotein 181
catenin 181
interleukin 6 181
NPY 179
FSH 177
glutathione peroxidase 174
glucose-dependent insulinotropic polypeptide 174
SARS 173
sterol regulatory element-binding protein 172
lymphoid 171
ATPase 170
alkaline phosphatase 168
more...
Disease
obesity 124988
diabetes 27445
hypertension 15328
type 2 diabetes 13374
metabolic syndrome 10003
cardiovascular disease 8296
cancer 7966
dyslipidemia 4625
atherosclerosis 3967
fatty liver 3794
glucose intolerance 3462
hyperglycemia 3131
hyperinsulinemia 3076
hyperlipidemia 2714
depression 2352
hyperphagia 2195
stroke 2064
tumor 2037
coronary heart disease 1835
breast cancer 1765
heart failure 1483
coronary artery disease 1459
hypercholesterolemia 1457
abdominal obesity 1430
chronic disease 1425
polycystic ovary syndrome 1415
obstructive sleep apnea 1370
asthma 1358
malnutrition 1304
cirrhosis 1266
heart disease 1208
myocardial infarction 1201
Nonalcoholic fatty liver 1191
morbid obesity 1175
liver disease 1172
renal disease 1122
alcoholic fatty liver 1080
osteoporosis 1076
gestational diabetes mellitus 1025
hepatocellular carcinoma 1015
sleep apnea 1005
Alzheimer's disease 933
osteoarthritis 916
cold 834
infertility 773
myocardial ischemia 689
carcinogenesis 659
colorectal cancer 659
type 1 diabetes 623
hypogonadism 615
endometrial cancer 589
overnutrition 589
metabolic disorder 575
essential hypertension 562
arthritis 552
hypoglycemia 533
infectious diseases 527
cognitive impairment 523
vascular disease 518
schizophrenia 516
chronic liver disease 515
Overweight and obesity 514
dementia 490
Brown 484
preeclampsia 480
gastroesophageal reflux disease 479
binge eating 477
prostate cancer 476
chronic obstructive pulmonary disease 472
hyperandrogenism 467
proteinuria 451
adenocarcinoma 447
rheumatoid arthritis 440
inflammatory bowel disease 440
addiction 437
HIV 432
hyperuricemia 428
gallstones 422
ischemia 422
anemia 420
ventricular hypertrophy 418
renal failure 412
prediabetes 405
tumorigenesis 401
Best 401
Cushing's syndrome 399
psoriasis 390
West 386
hypothyroidism 385
eating disorder 379
mental retardation 361
carcinoma 356
congestive heart failure 355
anorexia nervosa 354
colon cancer 353
plaque 353
Syndrome 346
mental retardation 344
bulimia nervosa 343
vitamin D deficiency 335
mental illness 324
cardiomyopathy 319
Bardet-Biedl syndrome 308
epilepsy 308
retinopathy 306
sleep disorders 301
sepsis 293
hepatitis C 293
autism 291
sepsis 285
chronic renal failure 280
diabetic nephropathy 276
tumor progression 273
gout 272
alcoholism 272
liver fibrosis 268
cardiovascular risk factor 260
anovulation 257
SEM 256
microalbuminuria 256
malabsorption 256
deep vein thrombosis 253
liver cancer 250
Evans 245
alcohol abuse 244
lipodystrophy 244
tumor growth 239
pulmonary embolism 236
neuropathy 232
pancreatic cancer 232
acute myocardial infarction 225
hepatitis B 222
Parkinson's disease 213
acanthosis nigricans 213
atherosclerotic cardiovascular disease 211
erectile dysfunction 211
acne 209
SARS 208
AIDS 207
FAS 205
liver cancer 204
pulmonary hypertension 203
pneumonia 201
abortion 193
migraine 193
arteriosclerosis 192
pancreatitis 192
wasting 190
virus infection 189
influenza 186
endocrine disorder 185
developmental delay 184
metastases 183
GSH 183
glomerulosclerosis 180
hepatitis 180
genetic disorder 180
major depressive disorder 179
Barrett's esophagus 178
adenoma 178
more...
Symptom
overweight 14147
pain 1229
hunger 923
fatigue 613
anesthesia 551
starvation 439
anorexia 430
sleepiness 368
headache 303
cachexia 297
stigma 289
snoring 287
hypotonia 279
angina 272
seizures 232
dyspnea 221
weakness 213
diarrhea 213
insomnia 190
vomiting 180
discomfort 166
hypercapnia 153
discomfort 151
nausea 145
respiratory distress 143
constipation 142
abdominal pain 135
collapse 133
back pain 110
analgesia 108
exhaustion 104
hypothermia 101
cough 99
hepatomegaly 87
low back pain 82
chest pain 74
polyuria 72
arthralgia 67
polydipsia 56
knee pain 53
wheezing 50
dizziness 46
ataxia 44
acute stress 43
tremor 43
heartburn 42
hypersomnia 40
masculinization 40
Ill 39
physical appearance 37
Depressive symptoms 37
nausea and vomiting 37
regurgitation 37
eds 36
lethargy 36
exertional dyspnea 35
distraction 33
menopausal symptoms 33
functional recovery 31
memory loss 30
Decreased activity 29
syncope 29
enuresis 28
Cushingoid 28
thinning 28
shortness of breath 28
corpulence 27
emaciation 27
Cushingoid 26
paresis 26
decreased appetite 25
bitter taste 25
agitation 25
Wind 24
paresthesia 23
alexithymia 22
splenomegaly 22
ketonuria 22
asthenia 22
dystonia 21
numbness 21
spasm 21
hot flashes 21
tinnitus 20
anosmia 19
myalgia 19
colic 19
bloating 19
vertigo 19
apathy 18
erythema 18
spasticity 17
acidity 17
chronic cough 16
microbial colonization 16
CSR 16
ENT 15
weight problem 15
Poor sleep 14
hyperoxia 14
pelvic pain 14
Multimorbidity 14
chronic constipation 14
HSA 13
Catch 13
acute abdomen 13
leg edema 13
despair 12
tachypnea 12
flushing 12
epigastric pain 12
heel pain 12
chronic back pain 12
dysuria 11
flank pain 11
cyanosis 11
abnormal breathing 11
dry eye 10
shoulder pain 10
acute abdominal pain 10
hemiplegia 10
pallor 10
dry skin 10
excessive sweating 10
acute pain 10
hyperemesis 9
nasal congestion 9
tingling 9
acid regurgitation 9
male subfertility 9
neck pain 9
rhinorrhea 9
hip pain 9
photophobia 8
oliguria 8
sore throat 8
hypoproteinemia 8
leg pain 8
abdominal discomfort 7
myoclonus 7
hot flushes 7
ophthalmoplegia 7
hepatosplenomegaly 7
hoarseness 7
dysarthria 7
Stiffness 6
skin damage 6
Physical findings 6
hypertonia 6
dental pain 6
night sweats 6
aphagia 6
irregular bleeding 6
paraparesis 6
sciatica 6
hypocapnia 6
blurred vision 6
bone pain 6
clubbing 5
rigors 5
more...
Drug
Cardiovasc 921
Dermatol 356
vitamin E 254
Asthma 241
caffeine 231
ascorbate 229
ROS 223
Orlistat 221
Glucagon 200
lysine 194
Bifidobacterium 164
Leaf 147
Rimonabant 132
Monit 122
niacin 116
Dial 109
Fructose 108
Growth hormone 101
Growth hormone 97
ADM 95
EPA 91
MAP 87
ROC 82
Liraglutide 75
Rosiglitazone 69
NADH 66
IL-2 63
Nephron 62
CSF 60
Spectrum 56
EE2 55
Vitamin A 53
PTH 53
Kenyan 48
Angiotensin II 48
Estrogens 46
lactose 43
citric acid 39
nitroglycerin 38
Portal 37
CTX 33
Vitamin E 32
ENT 31
ABC 29
Spectrum 29
CTX 29
CTX 29
IFN-gamma 29
Histamine 28
Dexfenfluramine 28
Glycerol 27
Asn 26
Posture 26
GHRP 26
Exenatide 26
ALA 26
Troglitazone 24
Albumin 24
Nephron 23
Ginseng 23
CAM 23
Retinoic acid 22
Award 22
Glutathione 21
Ethanol 21
p75 21
Glycyrrhiza 20
Check 20
Heme 19
Nitric Oxide 19
IL-1ra 19
CCL 18
Mazindol 18
Gel 18
THF 17
Android 17
Alliance 16
Rosuvastatin 16
Aloe 16
Ezetimibe 16
Diurnal 16
Monosodium glutamate 15
G-CSF 15
ICI 15
Dakar 15
Simvastatin 14
Capsicum 14
Mutagen 14
HCG 14
MRC 14
EPI 13
Olive oil 13
Rutin 13
DHT 13
Pravastatin 13
Diethylpropion 13
uPA 12
THA 12
Meridia 12
CPR 12
Ginger 12
DHT 12
TAK 11
Indomethacin 11
Norplant 11
Glide 11
BH4 11
Parkin 11
Parkin 11
ampicillin 11
PCB 10
ACT 10
VCR 10
Clopidogrel 10
HCH 10
Serum albumin 10
Meridia 10
Raloxifene 10
Epigallocatechin 10
Alanine 9
PTC 9
Luteinizing 9
Honey 9
Tacrolimus 9
Prednisolone 9
Activin 9
Carbenoxolone 8
GRF 8
Clonidine 8
Olmesartan 8
Valsartan 8
TAC 8
Ramipril 8
ETS 8
Liposyn 8
Vitamin B12 8
DM1 8
Gemfibrozil 7
NOV 7
Vitamin K 7
Captopril 7
Vitamin B 7
Fraction 7
Nebivolol 7
metformin hydrochloride 7
Thyroglobulin 6
Perindopril 6
AHF 6
Depo-Provera 6
Avandia 6
Biopolymers 6
DDAVP 6
Tocopherol 6
TAT 6
Acacia 6
Ranitidine 6
LMWH 6
DNase I 6
Hakka 6
DDAVP 6
more...
Enzyme
AMP-activated protein kinase 1475
mitogen-activated protein kinase 1243
renin 870
protein kinase 834
alanine aminotransferase 667
AMPK 659
AMPK 644
ERK 564
lipase 557
lipoprotein lipase 556
superoxide dismutase 411
aspartate aminotransferase 386
focal adhesion kinase 324
hormone-sensitive lipase 316
acetyl-CoA carboxylase 301
catalase 297
ACE 277
protein kinase C 229
CPT 223
luciferase 222
ATPase 185
phosphatidylinositol 3-kinase 181
glutathione peroxidase 179
alkaline phosphatase 168
NADPH oxidase 159
phosphoenolpyruvate carboxykinase 153
NADPH oxidase 145
11beta-hydroxysteroid dehydrogenase 139
AST 137
gamma-glutamyl transpeptidase 129
caspase-3 127
phosphodiesterase 125
NO synthase 121
LPL 121
peroxidase 116
citrate synthase 110
phosphoenolpyruvate carboxykinase 110
phosphoenolpyruvate carboxykinase 109
proteasome 109
BAT 108
tissue plasminogen activator 107
ACS 107
glucokinase 105
lactate dehydrogenase 100
diacylglycerol acyltransferase 99
MEK 97
IKK 96
calcineurin 94
glycerol-3-phosphate dehydrogenase 93
glycerol-3-phosphate dehydrogenase 92
demethylase 92
caspase-1 92
thrombin 92
glucose-6-phosphatase 91
phosphoinositide 3-kinase 90
APC 86
CPT 83
CPT 83
alpha-glucosidase 81
reverse transcriptase 79
tyrosine hydroxylase 79
collagenase 76
phospholipase A2 75
HSD 74
pyruvate dehydrogenase 74
acetylcholinesterase 73
GSK 72
complex I 72
PDK1 70
adenylate cyclase 66
glutathione S-transferase 62
creatine kinase 62
AOR 59
cholinesterase 59
xanthine oxidase 59
pyruvate dehydrogenase 57
pyruvate dehydrogenase 57
acyl-CoA oxidase 56
MAP 55
paraoxonase 52
CAD 51
CAD 51
CAD 51
glucose-6-phosphate dehydrogenase 49
prostate-specific antigen 49
arginase 48
carbonic anhydrase 48
AMP-activated kinase 48
aldehyde dehydrogenase 47
glutathione reductase 46
CYP7A1 46
furin 43
cytochrome oxidase 43
paraoxonase 42
succinate dehydrogenase 42
PARP 41
trypsin 40
RNA polymerase 40
ATP synthase 39
thromboplastin 39
guanylate cyclase 38
heme oxygenase 38
monoamine oxidase 38
MIP 38
NOS 38
phospholipase C 37
urokinase-type plasminogen activator 36
acyl-CoA synthetase 36
CD10 35
glyceraldehyde-3-phosphate dehydrogenase 35
hexokinase 35
acyl-CoA dehydrogenase 34
RNase 34
carboxypeptidase E 33
RNase 32
dipeptidyl peptidase IV 31
angiotensin-converting enzyme 2 30
cholesterol acyltransferase 30
nicotinamide phosphoribosyltransferase 29
subtilisin 29
phosphofructokinase 28
ceruloplasmin 28
aldehyde dehydrogenase 27
monoacylglycerol lipase 27
phosphorylase 27
NQO1 27
methylenetetrahydrofolate reductase 27
methylenetetrahydrofolate reductase 27
pyruvate kinase 26
3-hydroxy-3-methylglutaryl coenzyme A reductase 26
aldehyde dehydrogenase 25
aldose reductase 25
aldehyde dehydrogenase 25
aldehyde dehydrogenase 25
TOR 25
soluble epoxide hydrolase 25
sucrase 25
acyl-CoA synthetase 24
CaMKII 24
glucose oxidase 24
plasmin 24
3-hydroxy-3-methylglutaryl-CoA reductase 23
proprotein convertase 23
lactase 23
diamine oxidase 23
MMP 22
acid phosphatase 22
PKG 22
GRK5 21
kallikrein 21
glycerol kinase 21
isocitrate dehydrogenase 21
21-hydroxylase 21
glyceraldehyde-3-phosphate dehydrogenase 21
lipoxygenase 20
CYP3A4 20
histone acetyltransferase 20
isocitrate dehydrogenase 20
transcriptase 19
caspase-8 19
more...
Compound
glucose 18416
Clin 9042
Dec 8283
silver 5517
Insulin 2830
oxygen 2615
DNA 2373
water 2244
calcium 1637
TNF 1339
sodium 1323
Cardiol 1288
vitamin D 855
ATP 834
salt 775
nitric oxide 766
creatinine 736
iron 617
ethanol 584
glycerol 581
tyrosine 562
aldosterone 536
potassium 517
arginine 514
phosphate 510
Pac 498
acetate 461
cAMP 436
glutamate 415
zinc 411
serine 409
palmitic acid 398
Cholesterol 376
AMP 331
nitrogen 329
CoA 316
5-HT 306
palmitic acid 296
ACTH 294
alanine 283
Metformin 276
sulfate 275
Metformin 274
leucine 274
hydrogen 264
lysine 260
noradrenaline 259
Diabetol 258
CO2 257
urea 251
His 248
methionine 248
NAD 243
galactose 236
homocysteine 232
caffeine 231
Pima 224
DHA 220
Diabetol 218
nicotinamide 206
Glucagon 200
NAD 200
Oil Red O 197
threonine 197
GSH 195
GSH 195
retinol 192
tryptophan 189
Oil Red O 186
cysteine 184
Vitamin D 182
PMA 177
tryptophan 173
FFA 171
tryptophan 166
tryptophan 166
Testosterone 165
Testosterone 165
DBP 163
TSH 161
copper 159
DBP 159
ADP 157
Phe 153
Resveratrol 148
selenium 146
SDS 145
Sucrose 143
Optimal 141
retinoic acid 135
ADP 133
Sibutramine 132
ADP 131
iodine 131
MDA 130
Thyroid 129
Estrogen 129
Dial 128
glutamine 128
phosphorus 125
Ile 117
DSM 113
Estrogen 112
ASA 111
Fructose 108
NADPH 107
NADPH 107
6-12 106
acetyl-CoA 105
DPP 105
ACS 103
ACS 103
DHA 102
DHA 101
ethyl acetate 100
Angiotensin II 99
NH2 96
GABA 95
Bisphenol A 94
GABA 94
Bisphenol A 94
Melatonin 90
valine 89
EPA 89
oxalate 86
BMC 85
acetic acid 84
CPT 83
cGMP 83
CPT 83
Ang II 81
GDP 81
Cortisol 80
methanol 80
chromium 79
Gly 79
isoleucine 77
Sodium 77
Salt 77
nitrate 76
isoleucine 76
Curcumin 74
L-carnitine 73
THP 73
Asp 73
TOF 73
proline 72
malonyl-CoA 72
Hearts 70
MTT 70
Adrenal 68
PEG 68
adenylate 68
TRH 66
MEK 66
NADH 66
MAP 66
butyric acid 63
gallic acid 61
DBA 61
more...