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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum galanin, FSH, LH and estradiol levels were measured in 36 young obese women and in 16 young women with normal weight and normally menstruating (control group). Obese young women were characterized by higher serum galanin levels than normally menstruating women. There were no differences in FSH, LH and estradiol levels between study and control group. These results may suggest that galanin may play a role in the pathogenesis of obesity.
Ginekol Pol 1999 May
PMID:[The role of galanin in the etiology of obesity in young girls]. 1046 75

The authors present two middle-aged female patients with empty sella revealed at imaging studies (CT, MRI). Their main complaint was severe fronto-parietal and fronto-temporal headache. Physical examination showed obesity, hypertension, and local hypersensitivity on deep palpation and percussion in the above-mentioned regions, in both cases. Endocrine function of pituitary gland, visual fields and fundi were normal as was EEG. The CSF composition and pressure also showed no abnormalities. The diagnostic and therapeutic problems of empty sella syndrome are discussed.
Neurol Neurochir Pol
PMID:[Empty sella syndrome]. 1046 58

Obesity is a chronic complex disorder, which requires long-term treatment. The aim of this study was to estimate on the basis of current literature the coexistence of the cardiovascular system diseases and overweight. It was concluded that obesity is an independent risk factor for coronary heart disease, hypertension and heart failure.
Pol Merkur Lekarski 1999 Dec
PMID:[Obesity and cardiovascular diseases]. 1071 Sep 55

The aim of our study was to assess frequency of death from myocardial infarction in patients (pts) treated for small cell lung cancer (SCLC). 33 out of 845 patients treated for SCLC died from myocardial infarction. All patients were smokers. In 6 patients coexisted hypertension, in 2--diabetes and in 5--obesity. Eight patients have had cardiac disease in anamnesis. All patients were treated with one or more number of cardiotoxic drugs as DDP, VCR or VBL, E, MTX and ADR which are able to cause ischemic heart disease or myocardial infarction. Sixteen out of 33 patients have had radiotherapy of lung tumour. Death from myocardial infarction occurred from 0.5 up till 98.5 months from the beginning of start treatment. Eighteen men died from myocardial infarction in the first year of treatment. Risk of death from myocardial infarction was 15 times greater in men with SCLC than in men of the polish population at the same age and at the same time.
Pneumonol Alergol Pol 1999
PMID:[Myocardial infarction as a cause of death in patients treated for small cell lung cancer]. 1080 90

This study aimed at analysing an effect of the coronary risk factors and pharmacotherapy on the long-term outcome in women following the coronary artery by-pass. In 1004-1997, 253 female patients, aged between 33 and 82 years (mean [+/- SD] 57.0 +/- 8 years) were treated surgically. The follow-up period lasted for 7 to 60 months (mean 32.0 +/- 14 months). Ten patients (3.9%) died. Answers to the questionnaire and personal interviews assessed physical fitness based on CCS classification, pharmacotherapy, and presence of risk factors. According to CCS scale, significant improvement has been seen in 195 (82.6%; p < .0001) patients. Health state did not change in 34 (14.4%) patients, and deteriorated in 7 (3.0%). Analysisn coronary risk factors, hypertension proved prevailing (60.3%), followed by diabetes mellitus (25.5%) and obesity (22.9%). Eleven percent of patients returned to cigarettes smoking after surgery. Postoperatively, 74.1% of patients received nitrates as a constant, medication, 58.2%--beta-blockers, 53.4%--ACE inhibitors, and 19.8% of patients received calcium antagonists. Lipid abnormalities have been treated in 49.1% of patients whereas antiplatelet therapy has been carried out in 74.1%. Only 9.9% of patients received hormones. The lower CCS class before surgery, the more significant improvement after it. As pharmacotherapy was used according to the European guidelines, an improvement in the long-term outcome required some modifications in patients' life style.
Pol Merkur Lekarski 2000 Feb
PMID:[An influence of cardiovascular risk factors and pharmacotherapy on the long-term results in women undergoing coronary artery bypass]. 1080 40

In Poland and all over the world, there is a significant increase in the number of elderly persons (over 65 years). Evidently, cardiovascular disorders occur more frequently in the middle-aged and older people. Approximately 60 to 75% of persons over 65 years and older suffer from the myocardial ischaemic disorder or atherosclerosis. In the elderly, the same risk factors as in the other age groups are present, i.e. lipids metabolism failure, arterial hypertension, tobacco smoking, carbohydrates metabolism dysfunction, obesity, the lack of physical activity. The right arterial hypertension and lipids and carbohydrates metabolism dysfunction treatment connected with the cut out of the tobacco smoking are highly beneficial in the elderly suffering from the myocardial ischaemic disorder.
Pol Merkur Lekarski 2000 Feb
PMID:[Cardiovascular disease prevention in the elderly]. 1080 42

Obesity is associated with increased incidence of cardiovascular diseases, insulin resistance, dyslipoproteinemia and cancer. The discovery of leptin in 1994 has provided a lot of new information about obesity. Leptin is a 167-amino acid peptide synthetized almost exclusively in adipose tissue. This hormone circulates in blood serum in both free and bound forms. The long isoform of leptin receptor is widely distributed in brain, whereas numerous short forms are also being present in peripheral tissues. Leptin acts by binding to the receptors in hypothalamus and altering a release of several neuropeptides, especially neuropeptide Y, regulating energy intake and expenditure. Apart from signaling energy reserves to the brain, leptin promotes hematopoiesis, influences pubertal development and contributes to the increase in arterial blood pressure. Leptin production regulation in humans is poorly understood, but appears to depend on the total body fat, changes in energy intake and serum level of several hormones. Despite the recent advances in the knowledge of both physiology and pathophysiology of leptin, several many important questions require further studies.
Pol Merkur Lekarski 2000 Feb
PMID:[Leptin and obesity]. 1080 43

The fat cell, the functional entity of adipose tissue, is mainly involved in energy storage and mobilization. The deposition of fat in, and the mobilization of fat from, adipose tissue are precisely controlled by enzyme activities: LPL and HSL. These functions are under control of hormones such as insulin, catecholamines and, to some extent, steroid hormones. The adipocytes have been recently identified as the source of many factors that may act like hormones either in the local environment or at distant sites, are also target cells for many more hormones. Adipose tissue metabolism varies from one region of the body to another. The metabolic activity is the lowest in the subcutaneous gluteofemoral area, followed by the abdominal subcutaneous area, and the highest in the visceral region. The metabolic activity of gluteofemoral fat is activated in lactating mothers. Body fat content changes with female age. Puberty, parity and menopause seems to increase accretion of adipose tissue. Obesity is defined as an increase in body fat content. There is general agreement that obesity develops as an interaction between a genetic susceptibility and environment which is expressed when the subject is exposed to a certain set of environmental conditions. Obesity develops when energy intake exceeds energy expenditure over a prolonged period. Excess body weight is associated with several diseases which can shorten life expectancy. The prevalence of obesity is high and increases steadily. Approximately 20-40% of women are overweight (BMI 25-30 kg/m-2) and 5-20% are obese (BMI > 30 kg/m-2).
Ginekol Pol 1999 Jun
PMID:[Pathophysiological aspects of adipose tissue development in women]. 1089 89

Obesity-related metabolic and functional disorders may disturb adaptation process taking place in pregnant women body. Insufficient adaptation may lead to development of several medical complications during pregnancy, labor, delivery, and puerperium. Maternal obesity is associated with increased frequencies of hypertension, preeclampsia, gestational diabetes mellitus, fetal macrosomia, congenital malformations, labor abnormalities (including prolonged second stage of labor, meconium-stained amniotic fluid, FHR abnormalities and shoulder dystocia), postdatism, and cesarean delivery. Operative complications among obese women undergoing cesarean delivery include increased blood loss, prolonged operative time, and increased rates of postoperative infection, thrombophlebitis. Treatment of these complications increases hospital stays and costs. Obese women should be carefully examined by dietetician before conception and cared for dietetically and medically during gestation.
Ginekol Pol 1999 Jun
PMID:[Obesity as an obstetric risk factor]. 1089 90

Numerous complications of nephrotic syndrome due to either the illness itself or repeated courses of high-dose corticosteroids have been well recognised for several score years. However, investigations concerning children of ex-patients are lacking. The purpose of this study was to assess physical development and health state in the group of children whose mothers had suffered from the idiopathic nephrotic syndrome during their childhood. 34 such children were studied. Thorough medical history was taken from children and their mothers and available medical documents data were obtained. Physical examination was performed and centile position of weight, height and their proportion was stated. The authors found that stillborn foetus, premature or low birth weight newborn incidence is much higher than in general population and the percentage of overweight and obesity is higher in the studied group than in general population. To confirm these findings further investigations with greater number of patients are necessary.
Pol Merkur Lekarski 2000 Apr
PMID:[Health status and physical development of children delivered by mothers who suffered from nephrotic syndrome in their infancy]. 1089 16


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