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Elective total hip and total knee arthroplasty surgeries are associated with an extraordinarily high incidence of asymptomatic venous thromboembolism (VTE). Symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE) is diagnosed in only 2%-4% of these patients. A number of studies have defined the incidence and time course of symptomatic thromboembolism after these procedures. Knee arthroplasty is associated with a very high incidence of asymptomatic calf vein thrombosis, with almost all symptomatic VTE events diagnosed in the first 21 days after surgery. Hip arthroplasty, however, is associated with a higher incidence of asymptomatic proximal thrombi and a modestly higher incidence of symptomatic VTE events, many diagnosed up to 6 or 8 weeks after hospital discharge. Extended medical thromboprophylaxis has been shown to reduce the incidence of symptomatic and asymptomatic VTE among hip arthroplasty patients but not among knee arthroplasty patients. Risk factors for VTE after knee arthroplasty are not well defined. Important risk factors that have been shown to be associated with the development of VTE after hip surgery include (1) a history of prior VTE, (2) obesity (body mass index > 25), (3) delay in ambulation after surgery, and (4) female sex. Factors associated with lower risk include (1) Asian/Pacific Islander ethnicity, (2) use of pneumatic compression among non-obese patients after surgery, and (3) extended thromboprophylaxis after hospital discharge.
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PMID:Risk factors for venous thromboembolism after total hip and knee replacement surgery. 1217 37

Osteoarthritis (OA) presupposes the interaction of systemic and/or local factors. In hip joint OA, congenital or developmental malformation is believed to constitute an individual risk factor for premature degeneration. Hip dysplasia (HD) is such a malformation. The radiological and epidemiological studies had several aims: To critically evaluate the radiological source material of the Copenhagen Heart Study: The Osteoarthritis Substudy, consisting of 4,151 standardized, weight bearing pelvic radiographs recorded 1991-1994. To qualify or disqualify the radiological source material for further studies. To develop a comprehensible and reproducible radiographic discriminator of hip OA with as close an association to self reported hip pain as possible. To identify prevalences of hip OA and HD in a Caucasian, urban background population and investigate the influence of sex, age, physical and occupational parameters on these prevalences. To evaluate the influence of HD on hip OA development relative to other potential risk factors. To evaluate degeneration in dysplastic hips over time. To evaluate the three dimensional anatomy of HD and the distribution of degenerative features in severely dysplastic hips, and To evaluate risk factors for total hip replacement surgery. In the course of the studies we found that assessments of classic indices of HD were significantly influenced by pelvic orientation during x-ray recording and identified exclusion limits of rotation and inclination/reclination of pelvic radiographs to stay inside a measurement error of +/- 3 degrees. We found that minimum joint space width (JSW) </= 2.mm constituted a radiologic hip OA discriminator of superior reproducibility and clinical relevance compared to composite, radiological OA classifications. We documented a progressive postmenopausal decline in female minimum JSW, while male minimum JSW remained relatively unaltered throughout life. We found no evidence that smoking, occupational exposure to repeated, heavy lifting or overweight significantly influenced minimum JSW. Prevalences of hip OA was approximately 5.5% in subjects >/= 60 years of age, and HD prevalence was 4-10%, depending on the radiographic criteria applied. Age and HD were significant risk factors for hip OA development in women, and HD was found to be a significant risk factor for hip OA in men. However, only obesity was found to determine an event of hip replacement surgery. In a longitudinal study of 81 subjects and with mild or moderate hip dysplasia followed for a decade we did not document a tendency for radiological degeneration compared to 136 control subjects. In a computerized tomographic study of severely dysplastic hips we found a close relationship between insufficient anterior, acetabular containment and proximal femoral anteversion. The primary area of degeneration in dysplastic hips was in the antero-lateral quadrant of the joint.
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PMID:Adult hip dysplasia and osteoarthritis. Studies in radiology and clinical epidemiology. 1738 May 95

The contribution of obesity to the occurrence of cardiovascular events may not be wholly related to its influence on traditional risk factors. Coagulation and fibrinolysis may also influence cardiovascular risk, but the relationship of adiposity with these processes is unclear. The aim of the present study was to investigate the relationships of BMI (body mass index), waist circumference, hip circumference and WHR (waist-to-hip ratio) with VIIc (factor VII activity), plasma markers of thrombin generation [F1+2 (prothrombin fragment 1+2)], fibrin formation [SF (soluble fibrin)] and fibrin turnover (D-dimer), and PAI-1 (plasminogen activator inhibitor-1; a marker of fibrinolytic inhibitory capacity). The study cohort was 80 healthy postmenopausal women who were not diabetic, current smokers or taking hormone therapy and who had a fasting sample of blood collected. VIIc, F1+2, SF and PAI-1 were all positively correlated with BMI, waist circumference and WHR, whereas D-dimer was positively correlated with waist circumference and WHR, but not BMI. WHR was the strongest correlate of all the markers except for PAI-1, which was most closely related to BMI. Hip circumference became a negative correlate of F1+2 and D-dimer after adjusting for waist circumference. The relationships of WHR with F1+2 and SF, but not with VIIc and D-dimer, were independent of traditional risk factors. The positive association between waist circumference and markers of thrombin generation, fibrin production and fibrin turnover suggests that abdominal adiposity may contribute to atherothrombosis by activating intravascular coagulation. In contrast, a larger hip circumference appears to have a protective affect against coagulation activation.
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PMID:Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women. 1760 27

Abductor avulsion after primary total hip arthroplasty (THA) is an uncommon event and is associated with the lateral approach. Results of surgical repair have only been reported in one previous study. In a retrospective review of 2657 primary THAs, we identified 19 (0.7%) patients operated upon for repair of abductor avulsion on average 19 months after primary THA. The study's aim was to assess improvement in pain and limp, patient satisfaction, and functional outcome (Harris Hip Score) after surgical repair. Eighteen patients were evaluated at a mean follow-up of 38 months. Overall, only half of the patients had substantial improvement of both limp and pain. Limping and functional outcome markedly improved with early repair (<15 months), whereas obesity was associated with worse functional results.
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PMID:Results of surgical repair of abductor avulsion after primary total hip arthroplasty. 1853 95

Metabolic syndrome (MS), a constellation of metabolic risk factors associated with development of cardiovascular diseases and Type 2 diabetes (T2D), has emerged as a public health problem of enormous proportions in developed and developing countries. We have reported previously its prevalence in several island populations of the Eastern Adriatic coast of Croatia. In spite of leading a relatively traditional life style pattern including adherence to a Mediterranean diet, the prevalence of MS in these populations is high and comparable to that in developed nations. However, data on prevalence of MS among the mainland Croatian populations is limited. Therefore, we conducted a study in an outbred population comprising of Croats, Hungarians and Serbs from the Baranja region of mainland Croatia. Although this is an ethnically heterogeneous population, the constituent groups exchange mates and therefore, are not reproductively isolated. The life style patterns are also similar. Overall prevalence of MS, assessed by the National Cholesterol Education Program (NCEP) criteria, is 40% (35% in males and 42% in females) with Body Mass Index (BMI) as the predictor of obesity and 42% (52% in males and 39% in females) with Waist Hip Ratio (WHR) as the predictor of obesity. It is likely that, in addition to genetic risk factors, a host of environmental factors that include dietary habits and relatively urban life style in a modernized society have influenced the levels of the constituent metabolic traits leading to an increased prevalence of MS.
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PMID:Prevalence of metabolic syndrome in the interior of Croatia: the Baranja region. 1898 34

Obesity might be involved in the pathogenesis of osteoarthritis (OA) not only via increased mechanical loading, but also via an inflammatory component possibly causing increased pain and functional disability. The study aim was to examine the relationship between BMI and clinical symptoms as well as radiographic severity of OA in patients scheduled for primary total hip arthroplasty (THA). We conducted a cross-sectional study of 855 patients scheduled for a first THA for primary OA at a single centre between November 2001 and December 2006. The primary outcome was clinical and radiographic severity of OA, which was evaluated in four BMI categories (18.5-24.9, 25-29.9, 30-34.9 and > or =35 kg/m(2)). We used the Harris Hip Score (HHS) and the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) to assess pain and function. The severity of radiographic hip joint damage was evaluated using the Kellgren-Lawrence classification. Multivariate analyses were performed to adjust for potential confounders. In patients scheduled for THA, increasing BMI was associated with significantly higher levels of pain and functional disability on both HHS (P for trend <0.001) and WOMAC (P for trend <0.001). However, the degree of radiographic joint damage remained similar across BMI categories. These findings emphasize the need to further investigate the potential pathogenic role of obesity and low-grade inflammation in OA and underscore the importance of obesity prevention to avoid early prosthetic replacement of the hip.
Obesity (Silver Spring) 2009 Jul
PMID:BMI and severity of clinical and radiographic signs of hip osteoarthritis. 1919 52

The purpose of this study was to investigate the relation between the acetabular anteversion in primary total hip replacement (THR) and obesity. We hypothesised that the more difficult exposure of the acetabulum in obese patients through the posterolateral approach might compromise a proper acetabular cup positioning. More specifically, we expected to find an inverse relation between the BMI and the acetabular cup anteversion. Retrospectively 323 consecutive THRs were studied. From the postoperative radiograph the acetabular anteversion was calculated from the acetabular cup projection and the Body Mass Index (BMI) was calculated from the patients records. In the pooled data no statistical significant correlation could be established between the calculated anteversion and the BMI, nor between the inclination angle of the cup and the BMI.
Hip Int
PMID:Anteversion of the acetabular component in obese patients. 1919 53

Residual acetabular dysplasia leads to hip arthritis as a consequence of insufficient femoral head coverage which causes abnormal pressure on the joint cartilage. Spherical periacetabular osteotomy, described by H. Wagner, improves the acetabular coverage of the head. This surgical technique has been performed by the senior author, in Galeazzi Orthopaedic Institute of Milan, Italy since 1979. The purpose of this study is to evaluate the clinical and radiographic results of 14 patients affected by acetabular dysplasia and operated before 1985 by the same surgeon with this technique. The analysis of long term results (follow-up longer than 20 years) has shown that it is possible to achieve good clinical outcomes and to delay the need for total hip arthroplasty if a precise surgical technique is employed and if the correct indications are followed. Obese patients or hips with X-ray signs of osteoarthritis show the worst results in our experience. Our attitude is nowadays: full indication of spherical periacetabular osteotomy in dysplasia of the adolescent, indication in young adult patients only when some symptom is present, very rare indication in arthritis and only in very mild cases in young patients.
Hip Int 2007
PMID:Wagner's spherical periacetabular osteotomy: long term results. 1919 86

Hip fracture has been increasing in frequency for several decades, and 70-90% of patients who sustain a hip fracture survive for at least one year. Many of these survivors fail to regain their prefracture functional status. No work in this regard has been done in the developing world. Elderly patients with acute intertrochanteric fracture and fracture of the femoral neck were followed up prospectively for 12 months after surgery to record the mortality, morbidity, functional status and complications. Three hundred and forty-five patients (61% female) were assessed at six and 12 months after surgery, which included 62.9% intertrochanteric fractures and 37% femoral neck fractures. The mechanism of injury was from a fall in 67% of the cases. Nineteen patients died within six months after surgery while another eight died during the next six months. Obesity, male gender, multiple comorbidities and below normal ambulation status before fracture were identified as major determinants of bad functional outcome.
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PMID:Functional outcome, mortality and in-hospital complications of operative treatment in elderly patients with hip fractures in the developing world. 1947 32

The rate and mode of early failure in 463 Birmingham hip resurfacings in a two-centre, multisurgeon series were examined. Of the 463 patients two have died and three were lost to follow-up. The mean radiological and clinical follow-up was for 43 months (6 to 90). We have revised 13 resurfacings (2.8%) including seven for pain, three for fracture, two for dislocation and another for sepsis. Of these, nine had macroscopic and histological evidence of metallosis. The survival at five years was 95.8% (95% confidence interval (CI) 94.1 to 96.8) for revision for all causes and 96.9% (95% CI 95.5 to 98.3) for metallosis. The rate of metallosis related revision was 3.1% at five years. Risk factors for metallosis were female gender, a small femoral component, a high abduction angle and obesity. We do not advocate the use of the Birmingham Hip resurfacing procedure in patients with these risk factors.
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PMID:Early clinical failure of the Birmingham metal-on-metal hip resurfacing is associated with metallosis and soft-tissue necrosis. 1982 Dec 34


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