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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

100 IUD users (8 Dana super, 62 Dana super lux, and 30 Copper T) underwent an ultrasonic B-scan to localize their IUDs. For best results the patient must have a full bladder during the scanning. In 82 cases the IUD could be completely localized and in 11 cases partially localized. One case of erroneous interpretation due to uterus myomatosus was recorded. 6 dislocated IUDs were detected. The Dana super model could often be detected more quickly due to its form and the intensity of the echo complexes it produced. Localizations were also attempted on 6 IUD users in the first trimester of pregnancy. The IUD could be localized only in 4 of those cases; from the 10th week of pregnancy the IUD and the fetal sac could not be discerned separately. An insufficiently full bladder, a retroflex uterus, echoes caused by the intestine, and obesity made the ultrasonic scanning more difficult. This ultrasonic method of localization of IUDs is to be preferred to hysterography or hysteroscopy. It is recommended that such a localization be performed during the first three months after an IUD insertion to control its position or before the removal of an IUD and abrasio due to bleeding disturbances or other complications.
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PMID:[Applicability of ultrasonic B-scan diagnosis to localisation of intra-uterine contraceptive devices (author's transl)]. 38 50

To evaluate the effectiveness of highly purified glucomannan in childhood obesity a study has been carried out in 23 obese children (12 boys and 11 girls, aged 5.2-15.8 years), with excess weight of 51 +/- 16%, treated with 2-3 caps twice a day of glucomannan fibres (DICOMAN 5:2-3 gr/die), and in 30 obese children (aged 5-18 years) with excess weight of 51 +/- 10%, studied as controls. After a three-days food recall, a balanced diet with adequate caloric intake was provided to all obese children. In all patients before and 2-4 months after the auxological data (weight, height, weight excess) and laboratory data (serum levels of cholesterol, HDL, triglycerides, glucose, fructosamine, glycosylated hemoglobin, RBC, WBC, hemoglobin, iron, calcium, Cu and Zn) have been determined. Excess weight and triglycerides levels were significantly decreased in treated obese patients than in obese controls 4 months after the beginning of the study. A decrease of cholesterol levels was also observed in treated obese patients, but not in controls, whereas serum iron, calcium, copper and zinc persisted unchanged. No important side-effects were observed in treated patients. On the basis of our results highly purified glucomannan fibres may be employed with effectiveness in obese and dyslipidemic children together with diet.
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PMID:[The use of highly purified glucomannan-based fibers in childhood obesity]. 132 83

Trace metals are known to have important effects on the activity of metalloenzymes and insulin secretion and to be involved in the etiology of various diseases. This study was designed to investigate the distribution and concentration of selected trace metals in the tissues of genetically obese mice, which were known to have hyperinsulinemia. Different phenotypes (ob/ob; +/?) and sexes of 4, 8, 12 week-old mice were killed by decapitation. Metal levels (Zn, Cu, Cd, Cr) in the brain, liver, serum, hair and carcass were determined by an atomic absorption spectrometer. The results showed that obese mice had lower concentrations of zinc in the serum, hair, liver and carcass than lean controls (p less than 0.05), but there was no difference in the brain. Obese mice also had a low carcass cadmium concentration (p less than 0.01), which depended on the sex-age interaction. When expressed in terms of total content, obese mice had higher total liver zinc and carcass chromium contents (p less than 0.05). Obese mice had a higher total carcass copper content at 8 weeks of age. Serum and carcass zinc were showed to be inversely related to body fat in obese mice. The results indicate that zinc may play a special role in thermoregulation and fat metabolism in the liver of obese mice. The tissue distribution and absorption of zinc may have an important correlation in the development of obesity. The roles of copper, cadmium and chromium are still obscure, the related regulations are still open for further questions.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Investigation of the profile of selected trace metals in genetically obese (ob/ob) and lean (+/?) mice]. 135 9

A major concern with the use of starvation or semistarvation diets for weight reduction in severely obese people has been the reports of sudden death due to ventricular arrhythmias. Obesity per se is associated with cardiovascular changes, including left ventricular hypertrophy and prolongation of the QT interval. With weight loss, the mass of the heart and left ventricle decrease, but some signs of left ventricular dysfunction remain. The effect of weight loss on the electrocardiogram abnormalities of obesity appears to depend upon diet duration and upon whether protein and mineral nutritional status is maintained. Copper, potassium, and magnesium deficiencies may play important roles in promoting an electrically unstable heart. Stress, by eliciting autonomic imbalance, may act upon an electrically unstable heart to provoke acute arrhythmias in a subset of the obese population with QT interval prolongation.
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PMID:Cardiac effects of starvation and semistarvation diets: safety and mechanisms of action. 153 77

Zinc has recently been found to have important effects on metabolism and thermoregulation of obese individuals. The effects of zinc sulfate and thyroxine treatment on the obese patients were studied. The obese patients, selected from outpatients at the Taichung VGH, all had their body weight 20% higher than they normally should have, and body mass indexes (BMI = Wt/Ht2) greater than 25 kg/m2. They were separated into three groups to have 600mg zinc sulfate or/and 0.1mg thyroxine per day, respectively. Serum zinc and copper contents were determined by atomic absorption spectrometer. The alterative of body weight was also recorded. After 8 weeks of therapy, the zinc sulfate and zinc sulfate + thyroxine treatment had more significant effects on weight reduction (male: -1.10 +/- 0.38; -1.10 +/- 0.19, female: -1.75 +/- 0.19; -3.16 +/- 0.21 kg, P less than 0.05, respectively). The serum zinc content was found to inversely relate to the body weight reduction (r = -0.605, P less than 0.001). The results also showed that zinc sulfate and thyroxine treatment did not have satisfactorily greater effects on body weight reduction at short-term therapy on obese patients. We conclude that zinc therapy on the obese patients still need more evaluation and suggest that zinc may have important effects on the thyroid hormones conversion, and may have certain regulatory effects on the insulin activity through its interaction with thyroid hormones in the development of obesity.
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PMID:[Zinc sulfate and thyroxine treatment on the obese patients]. 165 39

Zinc is known to have important effects on insulin activity, to increase the body fat deposition, and thyroid hormones conversion (T4 to T3). It is also known to have intestinal absorption competition between zinc and copper. This study was to investigate the blood zinc and copper concentrations in NIDDM and obesity, the relationships among metals, insulin, and thyroid hormones were also determined. Blood samples of diabetic, obese, and healthy individuals were collected between 9-10 AM, and the blood levels of zinc, copper, insulin, T4 and T3 were assayed. The results showed that diabetics and obese individuals had higher insulin and T3 levels than healthy controls, but there was no difference in T4. The obese had lower serum zinc concentration. There were low levels of copper both in serum and erythrocyte, and a low erythrocyte zinc concentration in NIDDM. Blood zinc concentration was inversely related to T3 level in diabetics and obese individuals. It is suggested that zinc, insulin and T3 may have considerable correlations in the thermoregulation on NIDDM and obesity, and the true mechanisms still need more further studies in the future.
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PMID:[Investigation on the relationships among blood zinc, copper, insulin and thyroid hormones in non-insulin dependent diabetes mellitus and obesity]. 166 81

The content of seven main biometals: sodium, potassium, calcium, magnesium, zinc, copper, iron was studied in the blood serum of patients with alcoholic affection of the liver verified clinically and morphologically. In contrast to literature data, it has been established that the levels of the main elements in the blood serum of patients with alcoholic affections of the liver may be normal, and concentrations of zinc, copper and iron are even elevated. The initial body mass of patients significantly influences the mineral spectrum of the blood serum: the levels of zinc and copper in patients with excessive body mass and obesity were significantly higher than in those with normal body mass. The content of the main elements in the blood serum was not changed in relation to the degree of the liver affection and alimentary therapy.
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PMID:[Effect of diet on serum macroelement levels in patients with alcoholic lesions of the liver]. 179 68

The possible alterations of zinc and copper serum levels in dyslipemies were studied. The population were classified taking into account total cholesterol HDL and triglycerides levels and the serum test at 4 degrees C in 4 groups: 1) Hypercholesterolemia (type II A), 2) Endogenous hyperlipemia (types II B and IV), 3) Mixed hyperlipemia (type V), 4) Exogenous hyperlipemia (Type I), and also the presence of over weight ("15% ideal weight body, according to Bray), that occurred in the 29.5% of the sample. Zinc and copper were determined by AAS (Smith & Butrimovitz method). Total cholesterol, HDL, LDL and triglycerides by enzymatic methods. The main results and conclusions obtained were the following: A significative increase in zinc serum level was observed; Hyperglycemia, present in nearly half of the studied population could be the responsible for it. Obesity was associated with an increase of zinc values, and this could be related to an insulinic dysfunction. A direct correlation between glycemia and triglyceridemia, and between glycemia and zincemia was found. Cardiovascular alterations seemed to decrease zinc serum levels; on the opposite however hypertension increased them. Neither lipidic metabolism alterations, nor obesity did modify copper serum level.
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PMID:[Study of zinc and copper serum levels in dislipemias]. 202 Sep 19

Associations among serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and levels of serum zinc (S-Zn), serum copper (S-Cu), and their ratio were analyzed in 3373 3-, 6-, 9-, 12-, 15-, and 18-year-old Finnish girls and boys. S-Zn was positively related to total cholesterol, HDL-cholesterol, and LDL-cholesterol; S-Cu related negatively to HDL-cholesterol. Obesity did not affect these relationships. The few exceptionally high lipid levels found were not associated with very low or high S-Zn or S-Cu. S-Zn and S-Cu were related to serum lipids; causality between the variables, however, remains to be studied.
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PMID:Serum zinc and copper: associations with cholesterol and triglyceride levels in children and adolescents. Cardiovascular risk in young Finns. 260 70

The immune system plays a key role in the body's ability to fight infection and reduce the risk of developing tumors, autoimmune and degenerative disease. Nutritional deficiencies and excesses influence various components of the immune system. Early studies investigating the association between nutrition and immunity focused on generalized protein-energy malnutrition, particularly in children in developing countries. The extent of immunological impairment depends not only on the severity of malnutrition but on the presence of infection and on the age of onset of nutritional deprivation, among other factors. In industrialized nations, immune function has been shown to be compromised in many malnourished hospitalized patients, small-for-gestational age infants, and the elderly. Obesity also may adversely influence immune function. Imbalances of single nutrients are relatively uncommon in humans, and investigations of protein and amino acids and specific vitamins, minerals, and trace elements generally are carried out in experimental animals. Deficiencies of protein and some amino acids, as well as vitamins A, E, B6 and folate, are associated with reduced immunocompetence. In contrast, excessive intake of fat, in particular polyunsaturated fatty acids (e.g. linoleic and arachidonic acids), iron, and vitamin E are immunosuppressive. Trace elements modulate immune responses through their critical role in enzyme activity. Both deficiency and excess of trace elements have been recognized. Although dietary requirements of most of these elements are met by a balanced diet, there are certain population groups and specific disease states which are likely to be associated with deficiency of one or more of these essential elements. The role of trace elements in maintenance of immune function and their causal role in secondary immunodeficiency is increasingly being recognized. There is growing research concerning the role of zinc, copper, selenium, and other elements in immunity and the mechanisms that underlie such roles. The problem of interaction of trace elements and immunity is a complex one because of the frequently associated other nutritional deficiencies, the presence of clinical or subclinical infections which in themselves have a significant effect on immunity, and finally the altered metabolism due to the underlying disease. There are many practical applications of our recently acquired knowledge regarding nutritional regulation of immunity.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Nutrition, immune response, and outcome. 309 56


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