Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Obesity (Silver Spring) 2006 Apr
PMID:Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice. 1674 Dec 68


Obesity (Silver Spring) 2006 Apr
PMID:Temperature dependence of O2 consumption; opposite effects of leptin and etomoxir on respiratory quotient in mice. 1674 Dec 69


Obesity (Silver Spring) 2006 Apr
PMID:Peptide YY and proglucagon mRNA expression patterns and regulation in the gut. 1674 Dec 70


Obesity (Silver Spring) 2006 Apr
PMID:Weekly changes in basal metabolic rate with eight weeks of overfeeding. 1674 Dec 71


Obesity (Silver Spring) 2006 Apr
PMID:Value of heartburn for diagnosing gastroesophageal reflux disease in severely obese patients. 1674 Dec 72


Obesity (Silver Spring) 2006 Apr
PMID:Body mass index gain, fast food, and physical activity: effects of shared environments over time. 1674 Dec 73


Obesity (Silver Spring) 2006 Apr
PMID:Are the eating and exercise habits of successful weight losers changing? 1674 Dec 74


Obesity (Silver Spring) 2006 Apr
PMID:Trends and dietary determinants of overweight and obesity in a multiethnic population. 1674 Dec 75


Obesity (Silver Spring) 2006 Apr
PMID:Waist circumference correlates with metabolic syndrome indicators better than percentage fat. 1674 Dec 76

Several genes play a major role in obese phenotypes, and studies suggest that genetic variations among individuals, as well as their lifestyles, may bring about different body compositions. Among these genes, LEP, which codifies leptin, and the LEPR gene encoding its receptor were extensively studied for variants that could explain the obese phenotype. The LEPR p.Q223R gene polymorphism was analyzed in a sample of obese and nonobese individuals from Brazil to evaluate the role of this polymorphism in the obese phenotype in the population. Two hundred obese patients (60 males, 140 females, body mass index (BMI) >30 kg/m2) were screened, together with 150 lean or normal healthy individuals (63 males, 87 females, BMI <24 kg/m2). Genomic DNA was extracted and amplified by polymerase chain reaction (PCR). PCR products were digested with the restriction of endonuclease MspI, and separated by electrophoresis through an 8% polyacrilamide gel stained with silver nitrate. There was a significant difference in LEPR p.Q223R polymorphism frequency when comparing obese and lean subjects, with an odds ratio of 1.92 and a 95% confidence interval of 1.15-3.22 (P = 0.013). There is a strong association of the LEPR p.Q223R gene polymorphism with obesity in Brazil.
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PMID:p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. 1678 91


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