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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Obesity (Silver Spring) 2006 Feb
PMID:Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. 1664 59

The metabolic syndrome can be defined as a state of metabolic dysregulation characterized by insulin resistance, central obesity, and a predisposition to type 2 diabetes, dyslipidemia, premature atherosclerosis, and other diseases. An increasing body of evidence has linked the metabolic syndrome to abnormalities in lipid metabolism that ultimately lead to cellular dysfunction. We review here the hypothesis that, in many instances, the cause of these lipid abnormalities could be a dysregulation of the adenosine monophosphate-activated protein kinase (AMPK)/malonyl coenzyme A (CoA) fuel-sensing and signaling mechanism. Such dysregulation could be reflected by isolated increases in malonyl CoA or by concurrent changes in malonyl CoA and AMPK, both of which would alter intracellular fatty acid partitioning. The possibility is also raised that pharmacological agents and other factors that activate AMPK and/or decrease malonyl CoA could be therapeutic targets.
Obesity (Silver Spring) 2006 Feb
PMID:Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. 1664 60


Obesity (Silver Spring) 2006 Feb
PMID:Metabolic syndrome: focus on dyslipidemia. 1664 62

Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much effort, the underlying factors that are responsible for it are poorly understood. In this review, we focus on some recent advances in our understanding of the pathogenesis of insulin resistance in humans that have been made using magnetic resonance spectroscopy.
Obesity (Silver Spring) 2006 Feb
PMID:New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy. 1664 61


Obesity (Silver Spring) 2006 Mar
PMID:Behavioral assessment and characteristics of patients seeking bariatric surgery. 1664 94

This paper discusses the behavioral evaluation of patients who seek bariatric surgery and the psychosocial complications most frequently observed in these individuals. The effects of such complications on surgical outcome are briefly examined, as is the challenge of predicting therapeutic response on the basis of preoperative variables. The paper concludes with a description of the goals and methods of a behavioral assessment used at the University of Pennsylvania. This evaluation includes the use of the Weight and Lifestyle Inventory, a questionnaire that guides our interview with patients.
Obesity (Silver Spring) 2006 Mar
PMID:Behavioral assessment of candidates for bariatric surgery: a patient-oriented approach. 1664 95


Obesity (Silver Spring) 2006 Mar
PMID:A comparison of weight histories in women with class III vs. class I-II obesity. 1664 96


Obesity (Silver Spring) 2006 Mar
PMID:Previous weight loss experiences of bariatric surgery candidates: how much have patients dieted prior to surgery? 1664 97


Obesity (Silver Spring) 2006 Mar
PMID:Night eating syndrome and binge eating disorder among persons seeking bariatric surgery: prevalence and related features. 1664 98


Obesity (Silver Spring) 2006 Mar
PMID:Self-reported eating behaviors of extremely obese persons seeking bariatric surgery: a factor analytic approach. 1664 99


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