Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Obesity (Silver Spring) 2006 Jan
PMID:Eating in the absence of hunger: a genetic marker for childhood obesity in prepubertal boys? 1649 31


Obesity (Silver Spring) 2006 Jan
PMID:Night eating: prevalence and demographic correlates. 1649 32


Obesity (Silver Spring) 2006 Jan
PMID:Patient characteristics as predictors of weight loss after an obesity treatment for children. 1649 33


Obesity (Silver Spring) 2006 Jan
PMID:Racial differences in correlates of misreporting of energy intake in adolescent females. 1649 34


Obesity (Silver Spring) 2006 Jan
PMID:Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner. 1649 35


Obesity (Silver Spring) 2006 Jan
PMID:Central obesity as a risk factor for prostatic hyperplasia. 1649 36

We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity. Two hundred twenty-six obese aboriginal subjects (BMI > or = 27 kg/m2) and 182 aboriginal subjects with normal weight (BMI < 25 kg/m2) participated in this study. The polymorphisms of LEP G-2548A and LEPR Q223R were genotyped by polymerase chain reaction/restriction fragment length polymorphism, and their anthropometric characteristics were measured. Levels of leptin, triglycerides, and cholesterol were measured after overnight fasting. We found that the frequencies of the LEP G/G homozygote (22.6%) with Mendelian recessive (chi2 = 7.89, p = 0.005) and codominant (chi2 = 7.93, p = 0.02) models to be higher in the extremely obese subjects (BMI > or = 35 kg/m2) than in normal weight subjects (6.9%) but not in moderately obese subjects (35 > BMI > or = 27 kg/m2). There was no difference in genotypic frequency of the LEPR Q223R polymorphism between the extreme obese and control groups. We suggest that the LEP -2548 G/G homozygote plays a genetic recessive role in the development of extreme obesity in Taiwanese aborigines.
Obesity (Silver Spring) 2006 Feb
PMID:G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. 1657 41

Forkhead transcription factors of the FOXO subfamily are emerging as shared components of pathways that regulate a variety of cellular functions. In an effort to identify genetic polymorphisms in candidate genes to determine associations with BMI, we sequenced all exons of the FOXO genes (FOXO1a, FOXO3a, and FOXO4) and examined their associations with BMI in a Korean population (n = 734). Sixteen polymorphisms were identified in FOXO genes: three in FOXO1a, seven in FOXO3a, and six in FOXO4. Associations of FOXO polymorphisms with BMI were analyzed using multiple regression, adjusting for age and sex as covariates. One promoter single nucleotide polymorphism in the 5' flanking region of FOXO3a showed significant association with BMI, e.g., the lowest BMI (23.3 +/- 2.69 kg/m2) was discovered in individuals who were carrying T/T, intermediate BMI (26.6 +/- 3.14 kg/m2) was found in heterozygous individuals (C/T), and the highest BMI (27.2 +/- 3.47 kg/m2) occurred in individuals who were homozygous for the major allele (C/C; p = 0.01).
Obesity (Silver Spring) 2006 Feb
PMID:Polymorphisms in FOXO gene family and association analysis with BMI. 1657 42


Obesity (Silver Spring) 2006 Feb
PMID:Peptide YY levels are elevated after gastric bypass surgery. 1657 43


Obesity (Silver Spring) 2006 Feb
PMID:Resistin concentrations in murine adipose tissue and serum measured by a new enzyme immunoassay. 1657 44


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