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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study of fluid and electrolyte disturbances by isotope radiodilution method is carried out in 22 patients with chronic respiratory insufficiency and cardiac failure. The simultaneous measurements of hydro-ionic compartments have been carried out with tritiated water (HTO), labelled sodium (22Na), labelled potassium (42K) and labelled bromine (82Br). From these measurements, the various water spaces are calculated: total water (ET) and extracellular fluids (LEC), also exchangeable electrolytes: sodium (NaE), potassium (KE), chlorine (ClE) and derived values. Results are compared to corresponding values in controls with the same obesity index. Patients with respiratory insufficiency show a fluid and sodium rise, similar to that found in cardiac failure and denutrition. The (NaE + KE)/ET ratio is not significantly decreased and the natremia is only slightly lower. There is no real potassium depletion in most patients.
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PMID:[Isotopic study of fluid and electrolyte disturbances in decompensated chronic respiratory insufficiency (author's transl)]. 0 42

Plasma insulin responses to a 4-hour glucose tolerance (100 g) were studied in urbanized Black people. Persons of normal weight without diabetes (12) and obese persons without diabetes (18) were compared with obese diabetics (19). Fasting serum ketone levels were measured, and the plasma potassium, triglyceride and growth hormone responses during the glucose tolerance test were determined. Obese subjects without diabetes had a twofold greater total plasma insulin response (area under curve) than their counterparts of normal weight, but there was a progressive fall in total plasma insulin response from subjects with mild diabetes (with fasting normoglycaemia) to those with severe diabetes (with fasting hyperglycaemia). The early plasma insulin responses of the group with mild diabetes were significantly impaired, and the peak response was only reached at 120 minutes. The subjects with severe diabetes had a flat insulin response curve. Fasting serum ketone levels were highest in the group with severe diabetes. The growth hormone responses were similar in all the groups. Plasma potassium and tryglyceride levels fell less during the glucose tolerance test in the group with severe diabetes than in the other three groups. These data indicate that insulin secretion is reduced in obese Blacks with chemical evidence of diabetes and this reduction becomes severe in the symptomatic diabetic.
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PMID:Hormonal and metabolic responses to an oral glucose load in obese Black diabetics. 35 29

In severe obesity with adipose tissue hyperplasia it is difficult to achieve and sustain weight decrease by conventional therapy. Fifteen severely obese patients (mean body weight 135 kg) with hyperplastic obesity had a jejuno-ileostomy according to Payne to induce weight reduction by controlled malabsorption. Body composition, adipose tissue cellularity, and glucose tolerance were studied before and after the operation when the patients had reached a new stable weight (WS) a mean 21 months after surgery. Preoperative fat cell number was unchanged at follow-up in contrast to all other variables of body composition. Reductions in fat cell size were evenly distributed in different major subcutaneous regions. Body potassium was determined immediately after operation and at 6 months intervals until WS. The postoperative decrease stopped at 6 months, thus differing from the decrease in body weight. Significant positive correlations between the postoperative decrease in body weight or body fat, and preoperative body weight, body fat and body cell mass were analysed by multiple stepwise regression. Preoperative body weight and body fat were shown to predict postoperative weight loss at a leve of P less than 0.005. A positive correlation between body fat decrease and fat cell number could be explained hypothetically by an increased caloric demand in hyperplastic obesity.
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PMID:Body composition and adipose tissue cellularity before and after jejuno-ileostomy in severely obese subjects. 41 71

The content of extracellular fluid and total potassium was studied by total-body radiometry with 82Br and according to 40K in 162 females aged 41 to 55 years suffering from obesity. It was established that in patients with obesity the volume of extracellular tissue, in per cent, and the amount of total potassium, in gramms and millieequivalent per unit of actual body mass, were reduced. An increase in the content of extracellular fluid and a decrease in the level of total potassium in obese patients with circulatory insufficiency may be revealed only when the real content of extracellular fluid and the total potassium are stimated in relation to the unit of body surface. In obese patients with no signs of circulatory insufficiency these relative values hardly differ from the control values.
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PMID:[Extracellular fluid and total potassium content in obesity patients]. 43 Sep 59

Leucocyte magnesium concentration was measured in 25 hypomagnesaemic patients following a jejuno-ilean bypass operation for gross obesity. The mean plasma magnesium concentration in the bypass group was 0.67 mmol/l compared with that of 0.90 mmol/l in a group of 17 healthy volunteers, but the leucocyte magnesium concentration in the two groups was not significantly different. The plasma potassium was found to be significantly lower in the bypass group but there was no significant difference in the leucocyte potassium concentration in the two groups. Simultaneous measurements of erythrocyte magnesium, sodium and potassium were made. There was no evidence of intracellular magnesium depletion on the basis of the tissues studied.
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PMID:Leucocyte and erythrocyte magnesium levels after jejuno-ileal bypass surgery. 43 86

Breast-feeding contributes significantly toward the physical and psychological well-being of infants and health professionals should encourage mothers to breast-feed whenever possible. Nutritional advantages of breast milk include 1) a low sodium to potassium ratio; 2) an appropriate fat content; 3) optimal absorption rates for each compositional factor; and 4) high taurine levels which may promote nerve cell growth. Breast-fed infants are less likely to suffer from infant obesity than bottle fed infants. Most investigators agree that human milk affords the infant protection against infections; however, some diseases may be transmitted from the mother to the infant by breast feeding. Breast-feeding enhances the psychological well-being of both the mother and the child and strengthens the emotional bond between them. Breast feeding is contraindicated 1) for infants with phenylketonuria, rare amino acidurias, and galactosemia; 2) for infants whose mothers have diseases such as infectious tuberculosis and venereal disease; and 3) for infants whose mothers are taking medications which might be harmful to the infant. A history of breast cancer in the mother's family does not contraindicate breast-feeding. Hyperbilirubinemia in breast-fed infants can generally be prevented by the prompt initiation of breast-feeding following delivery and by providing the infant with frequent feedings throughout each 24 hour period. Infants with cleft palates can be breast-fed if they are fitted with a dental prosthesis. The threat of breast milk contamination by environmental pollutants is insignificant for most women in the U.S. Unless the mother has been exposed to an abnormally high level of chemical pollution, she need not worry about breast milk contamination.
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PMID:Breast-feeding and infant health. 52 12

Resting metabolic rate was measured in 22 women with varying degrees of obesity. Body composition was estimated from total body potassium and from total body water, and creatinine excretion in urine was measured over a period of three weeks while the patients were on a creatinine and creatine-free reducing diet. Resting metabolic rate was highly significantly correlated with body weight, surface area, creatinine excretion and lean body mass calculated either from potassium or water measurements (P less than 0.001). Correlation with adipose tissue was less strong, and when multiple regression of both fat and lean on metabolic rate was performed, the relationship was seen to depend mostly on the mass of lean rather than adipose tissue. In obese people the water content of fat-free tissue is greater than that in normal subjects, so it is not valid to assume that fat content can be calculated accurately from a measurement of total body water.
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PMID:Resting metabolic rate, weight, surface area and body composition in obese women. 52 17

Three women, aged 27, 33, and 35 years, experienced recurrent syncope five months after losing 36 to 41 kg using liquid protein diets. No abnormalities were noted during physical examination except in one who was hypothyroid. Serum potassium levels varied between 2.9 and 3.9 mEq/liter. The ECGs demonstrated prominent U waves, QUc prolongation, and ST and T wave abnormalities, with left axis deviation in two patients. Syncopal episodes were due to ventricular tachycardia and fibrillation, which were not responsive to conventional antiarrhythmic agents used in two patients. Patients using liquid protein diets may thus experience reversible QUc prolongation giving rise to serious arrhythmias that are probably best treated with drugs that shorten the QTc interval. Caution should be exercised in the use of liquid protein diets for weight reduction in obesity.
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PMID:Liquid protein diets and torsade de pointes. 66 Aug 27

The following methods for determining the body composition of obese individuals were compared: hydrostatic weighing; determination of total body water (distribution of antipyrine and of tritium oxide); determination of the total potassium content of the body; determination of the amount of excreted creatinine. The values for body fat which derived from the body density, from the total potassium content and from the distribution of antipyrine differed only to a small extent. These differences were not significant. But the value based on tritium oxide distribution differed significantly. The study of the body composition of obese individuals has clearly shown that the increase in body weight is significantly correlated with the increase in the proportion of fat in the body (r=0.444), with the increase in the absolute fat content (r=+0.898) and also with the increase in the proportion of lean body mass (r=0.826). Not only the fat (61.2%) but also the lean body mass (38.8%) contributes to the weight increase of obese individuals. The quantitative determination of the fat content of the body and of the fat-free substance not only serves to specify the diagnosis of obesity (in particular, it permits to detect the so-called latent obesity) but is also the basis of the assessment of certain function, e.g., energy metabolism. The effectiveness of different methods for losing weight may be evaluated by repeated determinations of the fat content and for the lean body mass.
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PMID:[Possibilities for determining body composition of man in relation to obesity]. 82 Sep 99

Four adolescents or young adults with the Prader-Willi syndrome (hypotonia, mental retardation, hypogonadism and obesity) received a protein-sparing modified fast consisting of 1.5 g of meat protein per kilogram of ideal body weight and meeting vitamin, mineral and fluid requirements. Evaluation of nitrogen and energy metabolism revealed the development of starvation ketosis and a positive nitrogen balance. Serial whole-body potassium measurements in two patients confirmed preservation of lean tissue despite continuing loss of weight. Clinical diabetes mellitus in two subjects was rapidly ameliorated by the regimen. Short-term weight loss greater than 18 kg occurred in three of the four subjects, and reduced weight persisted during observation periods of 26 to 44 months. This degree of outpatient diet adherence by mentally deficient subjects, who do not normally experience satiety, suggests that hunger is eliminated or at least reduced by modified, protein-sparing fasting.
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PMID:Metabolic aspects of a protein-sparing modified fast in the dietary management of Prader-Willi obesity. 84 Feb 78


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