Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0028754 (
obesity
)
124,988
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Deglucosylation and reglucosylation of glycoproteins by
glucosidase II
and uridine diphosphate-glucose: glycoprotein glucosyltransferase 1 (UGGT1), respectively, are important steps in glycoprotein quality control. Misfolded glycoprotein accumulation is associated with endoplasmic reticulum stress and can lead to protein misfolding diseases such as metabolic syndrome. Here, we analyzed the expression and activities of
glucosidase II
and UGGT1 in rat models of
obesity
and obese type 2 diabetes, and phenotypes associated with moderate and severe metabolic syndrome, respectively. In
obesity
, the mRNA and protein levels of
glucosidase II
and UGGT1 are decreased and their activities are reduced. In obese type 2 diabetes, the mRNA and protein levels of these enzymes are increased, and
glucosidase II
activity is slightly recovered, although UGGT1 activity is reduced. Our findings suggest that metabolic syndrome affects deglucosylation/reglucosylation enzymes according to disease severity.
...
PMID:Metabolic syndrome perturbs deglucosylation and reglucosylation in the glycoprotein folding cycle. 3223 44
