Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Endocrine dysfunction and parameters of metabolic syndrome were assessed in 91 patients aged 4.3-32.5 years who underwent allogeneic or autologous BMT in childhood. Final short stature, found in five of the 35 patients who attained final height, was associated with the underlying disease (specifically, Fanconi anemia) (P=0.0013), previous cranial irradiation (P=0.0007), type of conditioning irradiation (P<0.05) and allogeneic BMT (P=0.05). Growth hormone deficiency (n=10) was associated with previous cranial irradiation (P<0.005) and conditioning total body irradiation (P<0.001). Twelve patients had primary hypothyroidism, one had hyperthyroidism and one papillary thyroid carcinoma. Hypothyroidism was associated with neck/mediastinal (P<0.005) and conditioning irradiation (P<0.05). Primary gonadal failure was found in 24 of the mature patients (62.5% females). Hypogonadism was associated with the underlying disease (especially hematological malignancies) (P<0.05), pretransplant treatment (P<0.05), irradiation conditioning (P<0.001), older age (P<0.005) and advanced pubertal stage at BMT (P<0.05). Obesity (body mass index >2 s.d.) was found in 4.4% and type II diabetes and impaired glucose tolerance in 3.3% each. Dyslipidemia was found in 27.9% of the 43 patients tested. These findings emphasize the need for long-term follow-up of endocrine and metabolic parameters in young patients after BMT in order to offer proper treatment and improve quality of life.
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PMID:Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence. 1669 34

The aim of the study was to assess the energetic and nutritional values of diets in obese subjects (BMT > or = 30 kg/m2). A total of 261 patients of the Obesity Treatment Centre (201 women - BMI = 32.9 +/- 6.2 kg/m2 and 60 men-BMI = 33.4 +/- 5.3 kg/m2) were enrolled in the study. The mean age of women was 45.8 +/- 12.2 years, men 48.8 +/- 13.5 years. Daily food rations were performed using the 24h dietary recall referring to the day preceding the examination. Although the rations were shown to have a satisfactory energetic value they were improperly balanced with respect to protein and fat. Food rations of the study patients were characterized by excessive intake of animal protein, total fat, saturated fatty acids and dietary cholesterol, especially in men. Insufficient intakes of vegetable protein, total carbohydrates and dietary fibre were noted in the study patients of both sexes.
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PMID:[Quantitative assessment of daily food rations of obese persons]. 2036 67