Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Moderate physical activity (e.g., walking or bicycling) offers substantial health benefits. Physical activity is especially important for young persons not only because of its immediate benefits but also because participation in healthy behaviors early in life might lead to healthier lifestyles in adulthood. Persons aged > 2 years should engage in > or = 30 minutes of moderately intense physical activity on all or most days of the week. However, sedentary after-school activities (e.g., watching television or using computers), decreased participation in physical education, and fewer students walking or riding their bicycles to school might contribute to the high rate of childhood obesity. Walking to school provides a convenient opportunity for children to be physically active. To examine modes of transportation to school for Georgia children, the Georgia Division of Public Health analyzed data from the Georgia Asthma Survey conducted during May-August 2000. This report summarizes the results of that analysis, which indicate that < 19% of Georgia school-aged children who live < or = 1 mile from school walk to school the majority of days of the week. Statewide surveillance data of school transportation modes should be collected to monitor prevalence of walking to school.
 ...
PMID:School transportation modes--Georgia, 2000. 1220 85

Data from the 1998 California Behavioral Risk Factor Surveillance System (BRFSS) were examined. The BRFSS is an ongoing statewide telephone survey of randomly selected adults. The prevalence of self-reported lifetime asthma was 13.6% and the prevalence of active asthma was 6.6%. Prevalence rates were highest among African-Americans and lowest among Hispanics. Associations between asthma and gender, obesity, smoking, depression, migraine, and income were also examined. Active asthma was associated with low income, smoking, obesity, migraine, and depression in women, but not in men. The relationships observed suggest complex interactions between asthma and other chronic conditions, gender, and life-style.
J Asthma 2002 Aug
PMID:Self-reported asthma prevalence in adults in California. 1221 97

The evidence for an association between asthma and obesity in adults, and in children and adolescents, is reviewed. Few studies in adults measured height and weight, whereas the majority in children did. Evidence for the association is strong, but that for a gender interaction is weak. There is sufficient evidence to rule out asthma preceding obesity as an explanation, and that increased perception of symptoms in the obese, or a purely mechanical effect, is responsible. However, direct causality is unlikely, because in children the association is of recent origin, and trends in obesity do not explain the rising prevalence of asthma. Atopy was not associated with obesity in a large adult study. Potential explanations that require further investigation are that gastroesophageal reflux as a result of obesity causes asthma, that physical inactivity may promote both obesity and asthma, and that the diets of obese subjects may potentiate asthma.
J Asthma 2003 Feb
PMID:Obesity and asthma: evidence for and against a causal relation. 1269 7

The 2000 Behavioral Risk Factor Surveillance System (BRFSS) showed that Puerto Rico had the highest self-reported prevalence of asthma. Our objective was to estimate the self-reported prevalence of asthma among different population subgroups and determine its correlates in Puerto Rican adults as reported by the BRFSS. The BRFSS data gathered during 2000 were analyzed. To determine factors associated with self-reported prevalence of asthma, a simple unconditional logistic regression model was employed; then, to estimate adjusted weighted prevalence odds ratios, a multiple unconditional logistic regression model was used. The self-reported weighted prevalence of ever having asthma among Puerto Rican adults was 15.9% (14.8%-16.9%). Asthma prevalence was significantly higher in the following population subgroups: females (18.8%), educational attainment > 12 years (18.4%), having health coverage (16.3%), and obesity (21.0%). Asthma prevalence did not differ among age groups, region of residence, annual income, smoking at least 100 cigarettes in entire life, and physical activity. Almost half (45.6%) of asthmatics reported having children affected with the condition. The prevalence of asthma in any children of the interviewed was 33.2%, 51.3% were receiving treatment, and 30.6% and 24.3% reported having one to three visits to emergency departments and hospital admissions, respectively, resulting from asthma last year. Based on the logistic regression model, the following factors were significantly associated with asthma: sex, high educational attainment, health coverage and obesity. Consistent with previous studies in Puerto Ricans living in the mainland, a higher than expected prevalence of asthma was observed. The possibility of a genetic-environment interaction deserves further investigation.
J Asthma 2003
PMID:Prevalence and correlates of asthma in the Puerto Rican population: Behavioral Risk Factor Surveillance System, 2000. 1452 96

Obesity, a state that may be characterized by a low-grade inflammation, has been associated with asthma. C-reactive protein, an acute phase reactant, is elevated in obese people. However, little is known about how asthma affects C-reactive protein concentrations. Using data from 14,224 participants of the Third National Health and Nutrition Examination Survey (1988-1994), the author examined C-reactive protein concentrations among participants with current asthma (n = 651), who formerly had asthma (n = 303), and who never had asthma (n = 13,270). Compared with 21% of participants with current asthma, 11% with former asthma (P < .001) and 15% without asthma (P = .018) had C-reactive protein concentrations > or = 85th percentile of the sex-specific distribution. Compared with participants without asthma, the age-adjusted odds ratios for having an elevated C-reactive protein concentration was 1.49 (95% confidence interval [CI]: 1.11, 2.00) for persons with current asthma. After adjusting for age, sex, race or ethnicity, years of education, cotinine concentration, body mass index, waist-hip ratio, physical activity level, aspirin use, oral corticosteroid use, and inhaled corticosteroid use, the odds ratio decreased to 1.15 (95% CI: 0.83, 1.59). Body mass index was the main reason for the attenuation of the odds ratio. Whether the inflammatory activity associated with body mass index contributes to the pathophysiology of asthma is unknown.
J Asthma 2003
PMID:Asthma, body mass index, and C-reactive protein among US adults. 1462 29

Asthma and obesity are both chronic conditions and their prevalences have risen in affluent societies. A positive association between asthma and being overweight or obese has been reported in children and women, but associations in men are less clearly described. The objective of this study was to explore the association between body mass index (BMI) and asthma in men and women of diverse ethnic and socioeconomic background living in New York State, USA. In this study, we analyzed cross-sectional data on 5524 subjects aged 18 years and older who were interviewed by telephone in the 1996 and 1997 New York State Behavioral Risk Factor Surveillance System. Asthma (doctor-diagnosed), and weight and height were self-reported. BMI (kg/m2) was used as a measure of adiposity. Weighted logistic regression analysis, with stratification by gender and age, was used to examine the relationship between asthma prevalence and BMI, adjusting for race/ethnicity, education, health insurance, time since last physical examination, physical activity and smoking status. The results showed that the prevalence of asthma was 4.6% (CI: 3.6-5.5%) among men and 8.1% (CI: 7.1-9.1%) among women. In women, the prevalence of asthma was significantly increased in those with a BMI 25 kg/m2 or higher (BMI 25-27.5: OR = 1.76, 95% CI: 1.06-2.94; BMI 27.5-29.9: OR = 2.45, 95% CI: 1.41-4.25; BMI > or = 30: OR = 2.67, 95% CI: 1.66-4.29) when compared to the reference category (BMI: 22-24.9 kg/m2). In men, the prevalence of asthma was increased in the lowest weight category, BMI < 22 kg/m2 (OR = 3.05, 95% CI: 1.37-6.78) and in the highest category, BMI > or = 30 kg/m2 (OR = 2.92, 95% CI: 1.39-6.14). This U-shaped association persisted when restricting the analysis to men who had never smoked and was more pronounced for those between 18 and 49 years of age. In conclusion, this cross-sectional study showed that men and women differ significantly in the association between BMI and asthma prevalence only with respect to the lowest weight category. While women had a monotonic association, men showed a U-shaped relationship, indicating that both extremes of weight are associated with a higher prevalence of asthma.
 ...
PMID:Body mass index and the risk of asthma in adults. 1495 11

The prevalence of both obesity and asthma has risen in recent years. We sought to investigate whether obesity may be related to asthma. We undertook a retrospective medical record review of patient records at an inner-city academic asthma center. Obesity was defined as a body mass index (BMI) greater than 30. Asthma severity was defined by using the National Heart Lung and Blood Institute 1997 guidelines. Adults with a history of cigarette smoking or other lung disease were excluded. A total of 143 individuals aged 18-88 with a mean age of 43.9 met the entry criteria. There were 113 females and 30 males. Seventy-two percent of the sample was obese. The Spearman correlation coefficient showed a linear relationship between asthma severity and BMI (r = 0.40, p < 0.0001). Females with asthma were significantly more overweight than males, mean BMI 35.9 vs. 32.14, respectively (p = 0.01). The prevalence of obesity in the 13 patients on long-term oral corticosteroids was 100%. Prevalence of obesity increases with increasing asthma severity in adults. The association of asthma severity with obesity suggests that obesity may be a potentially modifiable risk factor for asthma or asthma-like symptoms.
J Asthma 2004 Aug
PMID:Relationship between asthma severity and obesity. 1536 59

Obesity and smoking are the two modifiable risk factors that contribute the most for many chronic diseases. Obesity has nearly doubled in Oklahoma and in the US since 1990 while Oklahoma adult smoking rates have remained above 25%. The purpose of this study was to utilize the Behavioral Risk Factor Surveillance System (BRFSS) to describe the associations between overweight, obesity, and cigarette smoking with selected chronic diseases among Oklahoma adults. The BRFSS is an ongoing, state-based, random-digit dialing telephone survey of the non-institutionalized adult population ages 18 years and older designed to collect various kinds of health-related information. Descriptive statistics were obtained for high blood pressure, high cholesterol, diabetes, asthma, and arthritis by BMI status (i.e. not overweight, overweight, obese) and smoking status (i.e., current, former, never). Logistic regression was performed to test for associations between BMI status or smoking status and these diseases. Self-reported diabetes, arthritis, and lifetime high blood pressure and high cholesterol rates were higher among those who were overweight and highest among those who were obese, while asthma rates were higher among obese adults than those who were not obese. Asthma rates were higher for those who currently smoke than former smokers and never smokers. Former smokers had significantly higher rates of high blood pressure, high cholesterol, diabetes, and arthritis compared to never smokers or current smokers.
 ...
PMID:Association of obesity and smoking with chronic diseases among Oklahoma adults. 1555 41

Our objective was to determine the impact of gender and age on asthma hospitalization rates among children. We used a population-based retrospective birth cohort study to determine yearly age- and gender-specific asthma hospitalization rates between ages 2-18 years in a cohort of all children born in Washington State between 1980-1985. In addition, we assessed factors associated with the hospitalization of a given child for asthma both before and during adolescence, and factors associated with an initial asthma hospitalization during adolescence. Outcome measures included age- and gender-specific rates of hospitalization for asthma, diabetes, seizures/epilepsy, and nonasthma respiratory diagnoses. Asthma hospitalization rates for boys were significantly higher than for girls between ages 2-12 years, the gender gap in asthma hospitalizations reversed between ages 13-14 years, and rates for girls were significantly higher than boys between 16-18 years of age. The male peak asthma hospitalization rate per 100,000 cohort members occurred at age 4 years (12.7; 95% confidence interval (CI), 11.1-14.3), and the male trough rate occurred at age 18 years (4.1; 95% CI, 2.8-5.4), whereas the female peak asthma hospitalization rate occurred at age 17 years (9.4; 95% CI, 7.8-11) and the female trough rate at age 2 years (5.2; 95% CI, 4.2-6.2). Age-specific hospitalization rates for diabetes mellitus and epilepsy were similar for boys and girls throughout childhood. Female gender was strongly associated with asthma hospitalization occurring in an individual child both prior to and during adolescence (rate ratio (RR), 2.0; 95% CI, 1.4-2.9), and was modestly associated with initial hospitalization in adolescence (RR, 1.15; 95% CI, 1.0-1.3). In conclusion, asthma hospitalization rates for boys and girls exhibit strikingly different patterns during adolescence. Potential explanations for these gender differences include hormonal changes during puberty, or gender-specific differences in environmental exposures such as diet, obesity, allergen exposure, or cigarette smoking.
 ...
PMID:Impact of adolescence and gender on asthma hospitalization: a population-based birth cohort study. 1569 May 59

The prevalence of asthma in the United States is higher than in many other countries in the world. Asthma, the most common chronic disease of childhood in the United States, disproportionately burdens many socioeconomically disadvantaged urban communities. In this review we discuss hypotheses for between-country disparities in asthma prevalence, including differences in "hygiene" (e.g., family size, use of day care, early-life respiratory infection exposures, endotoxin and other farm-related exposures, microbial colonization of the infant bowel, exposure to parasites, and exposure to large domestic animal sources of allergen), diet, traffic pollution, and cigarette smoking. We present data on socioeconomic and ethnic disparities in asthma prevalence and morbidity in the United States and discuss environmental factors contributing to asthma disparities (e.g., housing conditions, indoor environmental exposures including allergens, traffic air pollution, disparities in treatment and access to care, and cigarette smoking). We discuss environmental influences on somatic growth (low birth weight, prematurity, and obesity) and their relevance to asthma disparities. The relevance of the hygiene hypothesis to the U.S. urban situation is reviewed. Finally, we discuss community-level factors contributing to asthma disparities.
 ...
PMID:Population disparities in asthma. 1576 Feb 82


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>