Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0028754 (
obesity
)
124,988
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nafamostat mesilate
is a serine protease inhibitor and used for the treatment of pancreatitis and cancers. The fat mass and
obesity
-associated protein (FTO) was identified to be a demethylase and played an important role in physiological processes. The aim of this study was to examine the inhibition of
Nafamostat mesilate
on FTO demethylase activity. A combination of thermodynamic and enzymatic activity studies provides an insight into the recognition of
Nafamostat mesilate
by FTO. The binding of
Nafamostat mesilate
to FTO was driven by higher positive entropy changes and smaller negative enthalpy changes. The structural and thermodynamic information provides the basis for the design of more effective inhibitors for FTO. Our results might provide a novel target protein for
Nafamostat mesilate
.
...
PMID:Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase activity. 3039 14
