Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acceptable adverse effects and a clinical relevant weight loss of 3 to 5 kilograms have been found in long-term randomized clinical trials for sibutramine (Reductil) and orlistat (Xenical); these drugs may be prescribed for treatment of obesity for a duration of one and four years, respectively. This also seems to be the case for rimonabant (Acomplia), which is expected to receive approval in 2005 or 2006. However, until data on morbidity and mortality are available from RCTs, there is no absolute indication for prescribing drugs for treatment of obesity.
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PMID:[Drug treatment of obesity]. 1640 42

Obesity is a serious problem for modern medicine. Overweight and obesity themselves are qualified as disease entity and are also investigated as causes of numerous complications. It turns out that problems with maintaining a proper weight, concern not only adults, but also the youth and small children. Among populations of various nationalities a changing percentage of overweight and obese people is observed. This is caused by manner of nutrition, lifestyle and traditions. Poland belongs to a group of countries with a high index of obesity and a high percentage of diseases following the excessive growth of adipose tissue. Treatment of obesity is a complex and multidirectional process. It involves nonpharmacological, pharmacological and surgical methods. Until recently on Polish pharmaceutical market there have been preparations containing sibutramine. This substance is the inhibitor of serotonine reuptake and lessens the appetite with simultaneous increase of metabolism. However, it has been shown that sibutramine has adverse effects. Currently, Abbott Laboratories Poland company, which is the manufacturer of the original drug Meridia, containing sibutramine, informed about the suspension of sibutramine distribution in the UE territory. The case is being investigated. Therefore, it is crucial to make patients aware of the problems and consequences of unhealthy lifestyle and health negligence.
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PMID:[The obesity and way for treatment]. 2233 48


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