Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nasal continuous positive airway pressure (CPAP) is an effective therapy for sleep apnea. We treated 144 patients with nasal CPAP and observed them for periods of as long as 25 months. No pneumothoraces occurred in any patient. Compliance rates were between 65% (90/139) and 83% (90/108), depending on the patient population considered. Demographic factors unrelated to discontinuing using CPAP included age, sex, and the presence of a housemate. Better-educated patients were less able to tolerate the equipment. Dry throat and nose and sore eyes were the most common side effects, but only sore eyes related to the amount of pressure. Side effects were unrelated to the number of months on the treatment, and obesity was related to higher pressures. Our study provides optimistic intermediate-term follow-up observations of patients on nasal CPAP therapy for sleep apnea. Whether adverse consequences occur over longer periods of time remains to be seen.
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PMID:Compliance and side effects in sleep apnea patients treated with nasal continuous positive airway pressure. 265 26

The present multicentre study was aimed at comparably assessing the benefits and burdens associated with home mechanical ventilation (HMV). Hospitalisation, side-effects and health-related quality of life (HRQL) were assessed 1 month and 1 yr following HMV establishment using the Medical Outcome Study 36-Item Short-form Health Survey (SF-36; general HRQL) and the Severe Respiratory Insufficiency (SRI) Questionnaire (condition-specific HRQL). In total, 85 (27 chronic obstructive pulmonary disease, 29 restrictive thoracic, 17 neuromuscular, nine obesity hypoventilation syndrome and three miscellaneous) out of 135 eligible patients completed the study. Mean+/-SD SRI summary scale (range 0-100) improved significantly and comparatively in all 85 patients from 49+/-15 at baseline to 61+/-15 at 1 month and to 61+/-16 at 1 yr, but improvements of subscale scores differed amongst subgroups. SF-36 scores also improved, but the SRI was superior in detecting HRQL changes. Facial soreness and dry throat were the most commonly reported side-effects. Patients spent a mean+/-SD of 12+/-6 days in hospital at baseline and 3+/-3 days at each follow-up visit. Only four patients required unplanned hospitalisation. Overall general and condition-specific health-related quality of life aspects improved following home mechanical ventilation establishment independent of the underlying disease, which, however, has an impact on changes within specific health-related quality of life domains. The need for hospitalisation is low once home mechanical ventilation is carefully established.
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PMID:Impact of home mechanical ventilation on health-related quality of life. 1857 46