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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A random population sample from two countries of eastern Finland was studied in 1972, measuring eg the serum total cholesterol and triglycerides, blood pressure, and smoking. The participation rate among men aged 30 to 59 was 92%. Men who had had a myocardial infarction, angina or cerebral stroke in the preceding 12 months were excluded. During the seven-year follow-up 211 men had an acute myocardial infarction (AMI), 59 men had a cerebral stroke and 185 men died of any disease. The serum total cholesterol (greater than or equal to 8.0 mmol/l) had a positive association with the risk of AMI (relative risk RR = 2.8, 95% Cl = 1.8-4.3) and the risk of death (RR = 2.2, 95% Cl = 1.3-3.7) among men aged 30-49 but only with the risk of AMI (RR = 2.0, 95% Cl = 1.3-3.1) among those aged 50-59 based on multiple logistic models including also age, serum triglycerides, diastolic blood pressure, smoking and obesity. Serum triglycerides (greater than or equal to 2.8 mmol/l) had a positive risk factor-adjusted association with the risk of cerebral stroke (RR = 2.7, 95% Cl = 1.0-7.1) among men aged 30-49, but no independent association with the risk of AMI or death.
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PMID:Relation of serum cholesterol and triglycerides to the risk of acute myocardial infarction, cerebral stroke and death in eastern Finnish male population. 684 Sep 55

The immediate and late results of Weinberg's operation have been studied in 56 patients with chronic ischaemic heart disease (CIHD) with diffuse coronary sclerosis. Two control groups were compared; those with CIHD who were not operated on, and those who were subjected to pericardocardiopexy. The follow-up periods lasted from 6 months to 10 years. It was established that Weinberg's operation produced good effect in 76% of patients with chronic ischaemic heart disease. The operation is indicated in angina refractory to conservative therapy, with diffuse atherosclerotic lesions of the coronary bed, confirmed angiographically. Concomitant hypertensive disease, obesity, marked cardiosclerosis, recent myocardial infarction decrease the efficacy of Weinberg's operation.
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PMID:[Immediate and late results of Vineberg's operation in chronic ischemic heart disease with diffuse coronary arteriosclerosis]. 712 Jul 35

Adiposis dolorosa (Dercum's disease) is a syndrome of painful adipose tissue which occurs most often in post-menopausal women and is associated with obesity, asthenia, and emotional disturbances. The etiology is uncertain, but is probably multifactorial. Numerous treatments to relieve the pain have generally been unsuccessful. A patient with adiposis dolorosa was treated with intravenous infusions of lidocaine over a two-year period. Relief from pain lasted from two to 12 months after each infusion. A single-blind placebo infusion did not relieve the pain. Lidocaine infusions did not relieve the pain of diabetic neuropathy or of angina in this patient. The mechanism of relief of pain of adiposis dolorosa by lidocaine is uncertain, but previously reported central effects of lidocaine suggest that alterations in the central nervous system may be responsible.
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PMID:Intravenous lidocaine for the treatment of intractable pain of adiposis dolorosa. 712 48

Representative population samples of middle-aged women (1462 participants, a participation rate of 90.1%) were followed from 1968-1969 for 10 years with respect to morbidity and mortality from myocardial infarction, stroke and all causes of death. The same sample (1302 participants, 80.3%) was studied in 1974-1975. Data on the incidences of angina pectoris, intermittent claudication and hypertension in these women during the 6-year interval were analyzed. Obesity as a premorbid characteristic was estimated by weight index and sum of triceps and subscapsular skinfold thicknesses. The overall trends between weight index and the incidences of myocardial infarction and angina pectoris were weak, while there were excess frequencies in the top quintiles, indicating that only marked obesity constitutes an increased risk. The incidence of hypertension was positively correlated to both indices of obesity. The death rate irrespective of cause was negatively correlated to the sum of skinfolds but was not correlated to the weight index. The death rate from myocardial infarction seemed to be correlated to both obesity indices.
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PMID:Obesity in relation to morbidity and mortality from cardiovascular disease. 738 43

The purpose of the work was to reveal the informativeness of the factor of hereditary aggravation for prognosis of atherosclerosis of the aorta and cardiac vessels under conditions of mass preventive surveys. It was accomplished by the method of point evaluation of hereditary aggravation based on the distribution of the common genes in relatives of various kinship according to Galton's law of regression. It was found that the presence in relatives of first and second degree kinship of angina pectoris, myocardial infarction, hypertensive disease, stroke, diabetes mellitus, obesity and also cases of sudden death among them allow the appearance of atherosclerosis of the cardiac vessels and aorta to be prognosed both in the age and the clinical aspect.
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PMID:[Role of the heredity factor in the genesis of arteriosclerosis of the aorta and heart vessels]. 741 90

The authors examined the association between dietary intake of fish and omega 3 fatty acids from seafood and the risk of cardiovascular disease in a prospective cohort study of 21,185 US male physicians who are participants in the Physicians' Health Study. In 4 years of follow-up, there were 281 incident cases of total (fatal and nonfatal) myocardial infarction, 173 cases of stroke, and 121 cardiovascular deaths. There was no evidence for association between dietary intake of fish and any cardiovascular endpoint, including myocardial infarction, stroke, and cardiovascular death. The relative risks of total myocardial infarction, adjusted for age and randomized treatment assignment, for categories of fish intake were: 1.0 for < 1 meal/week (referent), 1.6 (95% confidence interval (Cl) 1.1-2.3) for 1 fish meal/week; 1.4 (95% Cl 1.0-2.0) for 2-4 fish meals/week; and 1.2 (95% Cl 0.6-2.2) for > or = 5 fish meals/week; chi 2 for trend = 0.9, p = 0.34. The relative risks were similar for omega 3 fatty acid intake and for specific types of fish, and did not change after adjustment for history of hypertension, hypercholesterolemia, diabetes mellitus, or angina pectoris, parental history of myocardial infarction before age 60 years, obesity, exercise, smoking, alcohol use, saturated fat intake, and vitamin supplement use. These data do not support the hypothesis that moderate fish consumption lowers the risk of cardiovascular disease.
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PMID:Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. 759 16

Two thousand, seven hundred and thirty-three patients with acute myocardial infarction (AMI) who were admitted to our 11 institutions between 1983 and 1988, examined by coronary arteriography and discharged alive, were followed for an average of 2.9 years. During the follow-up period, 212 patients (7.6%) died. The factors that governed the prognosis of myocardial infarction after discharge were advanced age, female gender, obesity, previous infarction, angina pectoris more than 1 month before the onset of AMI, post-infarction angina, multiple-vessel diseases, advanced stage by Killip's and/or Forrester's classification on admission, elevated pulmonary capillary arterial pressure, decreased cardiac index, decreased left ventricular ejection fraction, increased left ventricular end-diastolic volume and left ventricular aneurysm before hospital discharge. Patients with ventricular tachycardia or ventricular fibrillation during hospitalization showed a poor prognosis. In contrast, patients who received intracoronary thrombolysis, or emergent and/or elective percutaneous transluminal coronary angioplasty showed a favorable prognosis.
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PMID:Follow-up of 2,733 Japanese patients with myocardial infarction. 760 47

The management of essential hypertension can no longer be directed toward an isolated reduction in arterial pressure. Optimal reduction in the risk factors associated with hypertension and cardiovascular disease hopefully will reduce coronary heart disease, angina, fatal and nonfatal myocardial infarction, left ventricular hypertrophy, congestive heart failure, and sudden death. Hypertension is a genetic and acquired syndrome that consists of dyslipidemia, insulin resistance and carbohydrate intolerance, central obesity, renal abnormalities, structural abnormalities of smooth muscle, and ion transport abnormalities (membranopathy). The selection of pharmacologic agents should improve the components of the hypertensive syndrome by utilizing the "subsets of hypertension approach" to treatment.
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PMID:The management of hypertension and associated risk factors for the prevention of long-term cardiac complications. 769 47

To examine gender differences in the long-term prognosis of patients with myocardial infarction, 1000 patients with myocardial infarction were studied after coronary arteriography. Over a follow-up period of 3.3 +/- 2.0 years, 65 patients died from cardiac causes and 301 experienced cardiac events (death, reinfarction and revascularization). Overall, the 5-year cardiac mortality was 8%: that in females (12.4%) was significantly higher than that in males (6.6%) (p = 0.0073). The overall 5-year cardiac event-rate was 35%, with no significant difference between females and males (41.1% vs 33.3%). Univariate analysis revealed that differences in age (57.8 +/- 9.8 years in males vs 64.8 +/- 8.9 years in females, p < 0.0001), presence of smoking habit, obesity, hypercholesterolemia, hypertension, heart failure, right coronary artery disease, nicorandil administration, hypolipidemic, diuretic and anti-hypertensive treatment, and warfarin administration were present between men and women. The mortality rate in elderly females tended to be higher than that in their male counterparts. Multivariate analysis demonstrated that number of diseased vessels, post-infarction angina and left main trunk disease were significant predictors for cardiac death in both sexes, while gender was not. Therefore, gender did not appear to affect the long-term prognosis after age-adjustment among patients with myocardial infarction in the Western part of Japan.
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PMID:Gender difference in long-term prognosis after myocardial infarction--clinical characteristics in 1000 patients. The Kyoto and Shiga Myocardial Infarction (KYSMI) Study Group. 775 40

Risk factor profile of 142 patients with normal epicardial coronary arteries (86 males, 56 females, mean age 47 +/- 11 years) out of 1,508 consecutive patients undergoing coronary angiography was analysed. The mode of presentation in these patients was old or recent myocardial infarction (16.1%), unstable angina (12.0%), angina on effort (43.7%), atypical chest pain (8.5%), and anginal equivalent (19.7%). One or more stress test was positive in the majority (88%) of patients. Though the majority (39.5%) of patients had one risk factor, multiple (two or more) risk factors were not uncommon. Risk factor profile in patients with normal coronaries included hypertension (45.7%), dyslipidemia (33.8%), obesity (19.7%), positive family history of coronary artery disease (18.3%), cigarette smoking (16.1%), and minor risk factors (hyperuricemia, sedentary life style, Type A personality, oral contraceptive intake -15.4%). The mechanism of myocardial ischemia in patients with normal coronary arteries is not fully understood. We conclude that approximately one tenth of patients with clinically manifest coronary artery disease and one or more conventional risk factors do not have atherosclerotic changes in their epicardial coronary arteries as seen on coronary angiography.
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PMID:Profile of coronary risk factors in patients with manifest ischaemia and normal coronary arteries. 779 18


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