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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ninety-two pregnant and nonpregnant patients were randomly selected from two obstetric-gynecologic clinics for the purpose of investigating factors that affect the incidence and severity of vaginal candidiasis. Six factors were found to be significantly associated with the incidence of Candida albicans: drug addiction, obesity, birth control pills, pregnancy, antibiotic therapy, and diabetes mellitus.
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PMID:Candida albicans in women. 110 32

After a brief introductory discussion of methods generally used in the treatment of overweight (dieting; fasting; behavioral therapy; physical activity), the pharmacology of anorexigenic drugs and the considerations governing their clinical use and indications are discussed. All currently available anorexigens exert their action through nor-adrenergic stimulation at receptor sites located in the hypothalamus (amphetamine and ephedrine derivatives) or in the limbic system (Mazindol). In view of the CNS-stimulatory effect of these agents, drug addiction must be considered a potential hazard of their prolonged use. Since any drug treatment of obesity interferes with the patient's motivation to subject himself to the prolonged and possibly life-long changes in his eating habits and exertional behavior which are mandatory for the achievement of long-term therapeutic success, the use of drugs is rarely indicated in the treatment of obesity and should remain the exception. In view of their additional potential to induce drug addiction, this is particularly true of appetite suppressants.
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PMID:[Mode of action and indication for appetite depressants in the treatment of obesity]. 112 73

This paper assumes that there are two types of stress-related pathology, the orthodox and the paradoxical, both depending on a positive feedback mechanism controlling the stress-related sympathetic discharge. The paradoxical stress response is speculated to be the common basis for a group of conditions, including depression, panic attacks, obesity, sexual deviations, alcoholism, and drug addiction. Evidence is provided that trazodone inhibits the stress-related sympathetic discharge. This would provide a rationale for its use not only in depression, but also in other conditions depending on an exaggeration of the orthodox or paradoxical stress response.
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PMID:The paradoxical stress response: a possible common basis for depression and other conditions. 221 71

Three animal models, based on genetic differences in endogenous opioid peptides and opioid receptors, are described. Obese mice and rats, whose pituitary opioid content is elevated, may be used to investigate eating disorders. Recombinant inbred strains of mice, which differ in brain opioid receptors and analgesic responsiveness, can be used for study of opioid- and nonopioid-mediated mechanisms of pain inhibition. Individual reactivity to opioids can be examined in C57BL/6 and DBA/2 inbred strains of mice. A model that combines a variety of opioid effects is offered and suggests the existence of a genetically determined dissociation of opioid effects on locomotor activity and pain inhibition. In addition, stimulatory locomotor responses in the C57BL/6 reaction type are linked to a high risk of drug addiction and facilitatory effects on adaptive processes, while high analgesic potency in the DBA/2 reaction type is accompanied by a low proneness to drug abuse and amnesic properties of opioids.
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PMID:Opioids and behavior: genetic aspects. 283 10

In this Fourth Ruth Langton Memorial Lecture, the author highlights some of the major health problems in children, mentally and physically handicapped people, and in the growing numbers of elderly people in society. Nurses' roles are discussed. He identifies many major areas of concern and points out that many of the afflictions affecting people throughout the world, such as infectious diseases, blindness and malnutrition, could so easily be prevented. The author also focuses on the diseases caused by unhealthy lifestyles, in particular heart disease, cancers, drug addiction and obesity. He argues that a redirection of resources spent on arms and defense could do much to alleviate disease and suffering throughout the world. He also questions the present effectiveness of nursing education programmes and community care programmes. The paper concludes with a challenge to all nurses to explode the myth that society is becoming healthier, to face the reality of the urgent need for more primary health care and health education programmes, and to heal the dichotomy between present nursing and health care provision and the actual health needs of society.
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PMID:Nursing and health care in the twentieth century: myth, reality and dichotomy. 294 Feb 78

Due to asymmetry of brain neurotransmitters and differential hemispheric information processing modes, it is suggested that the excessive use of one information processing mode could engender a state of brain reactivity whose neurochemical correlates would be either a rise in melatonin or beta-endorphin in systemic circulation. Since melatonin and beta-endorphin have opposite effects on lung-mediated regulation of prostaglandins, it is further suggested that the pulmonary inactivation of prostaglandin E1 would either be increased or inhibited. Low levels of PGE1 would engender high levels of PGE2 whose effects would explain the findings in schizophrenics of: 'reducing' pattern of visual evoked response, cerebral atrophy, and viral and autoimmune phenomena. The primacy of the disordered cognitive style in leading up to the immunological, biochemical and neuropathological processes is stressed. Implications of this model for understanding depression, anxiety and phobic disorders, autism, attention deficit disorder, obesity, alcoholism, smoking, drug addiction, sexual deviations, and certain psychosomatic and psychophysiological disorders are suggested.
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PMID:How information processing mode could affect prostaglandin E1 metabolism and lung inactivation: relevance of hemispheric specialization, neurotransmitter asymmetry and brain reactivity. 614 17

(1) The initial treatment of obesity must include an attempt to modify previous eating pattern and may involve group therapy or behavioral modification. Drug treatment is not indicated unless this dietary approach is shown to be ineffective. (2) Since anti-obesity drugs do not help to establish a new and permanent eating habit, they should never be prescribed except as part of an overall management plan. (3) The potential for abuse with amphetamine and phenmetrazine is such that their use cannot be justified as anorectic agents. (4) Phenmetrazine, diethylpropion, mazindol and fenfluramine will all produce an additional mean weight loss of approximately 0.2 kg per week. They are contraindicated if there is a history of drug misuse, drug dependence or psychiatric illness. They should always be prescribed with caution. With the exception of fenfluramine, they are best given intermittently on the grounds of efficacy, safety and cost benefit. (5) The individual response to drug therapy is extremely variable and may reflect differences in drug pharmacokinetics, metabolic adaptation or, less frequently, drug tolerance. (6) Following drug withdrawal, weight regain is the rule. It follows that therapy can most easily be justified if there is a short term need for weight loss, e.g. prior to elective surgery. (7) The safety and efficacy of long term drug therapy has yet to be established. It may prove justifiable in patients most at risk from obesity or from obesity associated disorders such as diabetes and hypertension. However, at present the only established indication for prolonged administration of the currently available drugs is the use of metformin in insulin independent diabetics. (8) The indications for the pharmacological treatment of obesity remain poorly defined. A number of new approaches are being evaluated, and the future may lie in the development of drugs which enhance thermogenesis or primarily act upon the gastrointestinal tract.
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PMID:Drug treatment and obesity. 676 69

Disgust with "fatness" and a consequent preoccupation with body weight, coupled with an inability to reduce it to or sustain it at the desired low level, characterizes the abnormal normal weight control syndrome. Individuals remain sexually active in a biological sense and often also socially. Indeed their sexual behaviour may be as impulse ridden as is their eating behaviour, which often comprises phases of massive bingeing coupled with vomiting and/or purgation. The syndrome is unlike frank anorexia nervosa in that the latter involves a regression to a position of phobic avoidance of normal body weight and consequent low body weight control with inhibition of both biological and social sexual activity. In abnormal normal weight control there is a strong and sometimes desperate hedonistic and extrovert element that will often not be denied so long as body weight does not get too low. Individuals nevertheless feel desperately "out of control" and insecure beneath their bravura. The syndrome is much more common in females than in males. There is a clinical overlap with anorexia nervosa and obesity in many cases as the disorder evolves. Depression, stealing, drug dependence (including alcohol) and acute self-poisoning and self-mutilation are common complications. Clinic cases probably only represent the tip of the iceberg of the much more widespread morbidity within the general population. Like anorexia nervosa and for the same reasons the disorder is probably more common than it used to be.
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PMID:Anorexia nervosa at normal body weight!--The abnormal normal weight control syndrome. 730 91

Fewer men responded to a personal advertisement in which a woman identified herself as obese than to one in which she indicated a history of drug addiction. The men who responded to the two advertisements also disclosed their own obesity or addiction.
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PMID:Men's preferences in romantic partners: obesity vs addiction. 864 81

Yesterday. School hygiene acted in a clear way. Physician, pediatrician, nurse and hygienist were employed at school and were responsible for carrying out periodic examination, vaccination of school children and youth. They also supervised groups of children with posture defects, obesity, underweight, circulatory system and respiratory tract (asthma, anaphylaxis), diseases nervous system disorders and also propagated health education at school. Inspector of Pediatrics and School Medicine was in charge of School Medical Care. Today. Reform of the Public Health System. Medical examination and services have their value in money. A school physician, some hygienists and school nurses have been dismissed to decrease the financial costs of school hygiene. All medical services must be bought by the National Health Service. Public and private medical services at doctors and nurses are organized at schools. Each service performs examinations, vaccinations bought by the National Health Service or parents. A pupil is a subject of buying medical services. He may be vaccinated by a nurse but a medical examination must be either bought or performed by home doctor. The supervision of school children with different illnesses is not conducted by a school doctor. At present all the threats of contemporary world such as alcohol, tobacco, drug addiction, nervous system illnesses and allergies which are destructive for youth start when they are teenagers. School is an important place for carrying out on a large scale prophylactic services with medical teams of paediatricians, rehabilitation specialists and psychologists. Tomorrow. School Hygiene at School. Not at home doctor's. Recommendations, Daily Hygiene: personal, oral, food mental.... Hygiene of studying, rest and daily effort. Struggle with mass media, alcohol, drug, Internet, Computer addiction, violence, stupidity and poverty. School Hygiene should be adjusted to youth's health needs in accordance with the recommendations of European Society for Social Pediatrics (ESSOP) and Committee on Public Education, American Academy of Pediatrics and reinforced, it should not be eliminated.
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PMID:[School hygiene in the past, present and future--in the opinion of the Inspector of Pediatrics and School Medicine and member of the European Society for Social Pediatrics (ESSOP)]. 1500 12


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