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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

106 IUD user, parous women (1.9-2.2 births) with an average age of 29.8 years and findings of triglyceridemia of 1.65 mmol/1 and cholesterolemia of 5.9 mmol/1 were studied. The control group consisted of 114 parous women (2.1 children) nonusers with an average age of 26.7 years and findings of triglyceridemia of 1.72 mmol/1 and cholesterolemia of 6 mmol/1. The IUD users were divided into 4 groups according to duration of use: 1-12 months, 13-24 months, 23-36 months, and 36 months. 45 women used Norbiogest, 34 used Neogest, 19 used Ovidon, 26 used Yermonil, 15 used Biogest, and 3 used Nonovlon. The incidence of cholelithiasis, measured by the 3.5 mHZ linear cholecystic sound of the SAL-22A ultrasonographic device made by Toshiba, was 13.2% in 106 IUD users vs. 10.5% in 114 nonusers, a finding without statistical significance. The rate of cholelithiasis was 20% in those who used IUDs for 36 months (average of 51 months) which was statistically significant when compared to the first group (10.9% rate) or controls (10.5%). The rate of longterm IUD users was similar to those who had had 3 pregnancies in their anamnesis (21.5%). Prolonged use of IUDs exceeding 3 years was associated with increased risk of developing cholelithiasis, but the levels of triglycerides and cholesterol were not different in the 2 groups. The following risk factors of the disease have to be considered for judging pathogenic potential: family history, prior birth, and obesity.
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PMID:[Do oral contraceptives increase the risk of developing cholelithiasis?]. 366 52

The presence of a diagonal ear lobe crease (DELC) was studied in 350 non-selected patients admitted to the Clinic. The overall incidence of DELC was 45%, with a significant increase after the age of 50 years (24.8% before and 59.5% after fifty, p less than 0.001). The relationship between DELC and ischemic chronic heart disease (65% as against 23% in the patients without DELC, p less than 0.001) and with some coronary risk factors: arterial hypertension (40% in patients with DELC, 29% in those without, p less than 0.01), smoking (43%) as against 35% in those without DELC. The relationship with diabetes mellitus and obesity was not significant. A higher incidence of DELC was observed in males (66%) than in females (34%) (p less than 0.02). The lipid profile of patients with DELC presents significant cholesterolemia changes (251 +/- 71 mg as against 232 +/- 70 mg in those without DELC) and a less marked increase in lipemia and beta-lipoproteins. All risk factors presented a net increase in the subjects with bilateral DELC. It is concluded that DELC can be used for selecting asymptomatic subjects in the screening of a possible coronary heart disease.
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PMID:Relation between diagonal ear lobe crease and ischemic chronic heart disease and the factors of coronary risk. 372 21

Pulse wave velocity was measured in 27 obese and 25 nonobese patients with sustained essential hypertension. Pulse wave velocity was significantly increased in obese patients in comparison with nonobese patients. The result was independent of age, sex, and level of blood pressure. In the overall population, a significant positive correlation (r = 0.85; p less than 0.001) was observed between the degree of obesity and pulse wave velocity. A study of partial correlation coefficients indicated that the levels of glycemia, cholesterolemia, and triglyceridemia did not influence the relationship. After body weight was reduced, blood pressure decreased and arterial compliance increased. The results show that in patients with sustained essential hypertension: pulse wave velocity and obesity are strongly related independent of age, sex, blood pressure, and associated metabolic disorders and body weight reduction is associated with an improvement of arterial distensibility and compliance.
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PMID:Pulse wave velocity in patients with obesity and hypertension. 372 68

The effects of portacaval anastomosis (PCA) on cholesterol biodynamics of male adult (fa/fa) Zucker rats and their lean littermates were studied with an isotopic equilibrium method. Animals were fed with a sucrose-rich semi-purified diet. Obese rats were hypercholesterolemic (2.03 +/- 0.14 vs 1.06 +/- 0.7 mg/ml), had a cholesterol-enriched liver (135.3 +/- 14.5 vs 40.0 +/- 2.6 mg/liver) and accumulated cholesterol in body pools. However no difference in the rates of cholesterol absorption, synthesis, fecal elimination or transformation into bile acids distinguished obese from lean Zucker rats. In both lean and obese rats, PCA decreased cholesterolemia by about 28 per cent and liver weight by 40 per cent while the total cholesterol content of the liver was not affected. Input of synthesized cholesterol (internal secretion) was strikingly decreased by the shunt (from 13.2 +/- 0.6 and 12.6 +/- 0.7 mg/day/rat before PCA, to 8.9 +/- 0.8 and 8.6 +/- 1.0 mg/day/rat after PCA) in lean and obese rats respectively. A similar decrease was observed in the cholesterol transformation into bile acids. Since the activity of the gut for cholesterol synthesis, as shown by the fecal external secretion (cholesterol synthesized by the gut and directly eliminated in the gut and feces) was probably not modified, the reduction of internal secretion induced by PCA resulted from decreased hepatic cholesterogenesis. It is suggested that this decrease may be one of the factors involved in the lowering effect of PCA on plasma cholesterol level.
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PMID:Cholesterol metabolism in lean and obese Zucker rats: effects of portacaval anastomosis. 401 13

The authors address the two following questions: 1) Is detection of glycoregulation disorders possible from data yielded by routine annual examination (7,923 subjects)? 2) Do further investigations, carried out in a subdivision of subjects selected according to the risk of cardiovascular disease (n = 1,232), show a difference in the distribution of risk factors and risk indicators between patients and "healthy" individuals? Analysis of the results of this transversal study demonstrates a fact that is well-known concerning diabetes: even mild hyperglycemia (greater than or equal to 6 Mmol/l) is significantly correlated to age, excess weight and high systolic blood pressure. In both male and female subjects, there is a strong correlation between mean blood glucose concentration and the other biologic parameters that were studied (blood pressure, serum cholesterol, LDL/HDL cholesterol). Conversely, no correlation was found with smoking habits or with the intake of various dietary components. These results indicate that age, excess weight and increased blood pressure are simple data which are suggestive of abnormal glycoregulation. Comparison of risk factors and risk indicators in patients and "healthy" subjects showed significant differences for age, smoking habits and systolic blood pressure only. Glycemia, cholesterolemia and obesity were similar in both groups. These findings are evidence of the high risk in the subjects considered as "healthy", in whom the degree of atherosclerosis cannot be ascertained. Atherosclerosis in "healthy" individuals can certainly not be overlooked: in subjects with normal blood pressure, fundus examination showed a similar proportion of abnormalities in patients and "healthy" individuals.
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PMID:[Screening for blood glucose abnormalities and coronary heart disease through routine annual examination (author's transl)]. 628 34

The authors mention the previous conditions to the prescription of a diet for primary hyperlipoproteinemia : definition of the metabolic disease and of its nutritional dependence, precise knowledge of earlier nutritional uses, demonstration of vascular risk factor linked to the hyperlipoproteinemia, i.e. obesity which always requires a hypocaloric diet. A low cholesterol and saturated fatty acid diet reduces by 10% the cholesterolemia, and sometimes exempts from use of medical drugs in moderate hypercholesterolemia. The exceptional hyperchylomicronemia are reduced by drastic reduction of the lipid fraction of the diet, which is compensated by use of MCT. The dietetic treatment of endogenous hypertriglyceridemia depends on their nutritional dependence : an alcohol dependence implies a complete suppression of alcoholic drinks. A glucid dependence implies the suppression of simple carbohydrates and a reduction of the glucidic fraction of the diet.
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PMID:[Dietetic treatment of hyperlipoproteinemias]. 631 17

The authors mention the previous conditions to the prescription of a diet for primary hyperlipoproteinemia: definition of the metabolic disease and of its nutritional dependance, precise knowledge of earlier nutritional uses, demonstration of vascular risk factor linked to the hyperlipoproteinemia, i.e. obesity which always requires a hypocaloric diet. A low cholesterol and saturated fatty acid diet reduces by 10% the cholesterolemia, and sometimes exempts from use of medical drugs in moderate hypercholesterolemia. The exceptional hyperchylomicronemia are reduced by drastic reduction of the lipid fraction of the diet, which is compensated by use of MCT. The dietetic treatment of endogenous hypertriglyceridemia depends on their nutritional dependance: an alcohol dependance implies a complete suppression of alcoholic drinks. A glucid dependance implies the suppression of simple carbohydrates and a reduction of the glucidic fraction of the diet.
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PMID:[Diet treatment of hyperliproteinemias]. 634 41

Three experiments were carried out to compare plasma lipid and glucose concentrations in genetically lean (LL) and fat (FL) male chickens. The fat birds always displayed lower glycemia than the lean ones, irrespective of the diet (low-fat or fatty) and nutritional state (fed or fasted). Conversely, triglyceridemia was higher in the fat than in the lean line, particularly in the fed condition. This difference was more pronounced in the birds fed on a low-fat diet and became still more marked as they aged. No consistent differences were found between the two lines as to cholesterolemia and non-esterified fatty acid concentrations. Injections of Triton WR 1339 increased triglyceridemia; this effect tended to be more pronounced in the fat birds. The rate of increase of triglyceridemia did not plateau as the dose of Triton increased. The injection of Triton frequently led to convulsions and death. It is concluded that this model of genetic fatness is different from the monogenic models of mammalian obesity since hypertriglyceridemia was not systematic and was not associated with hyperglycemia or hyperinsulinemia.
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PMID:Effects of age and diet on plasma lipid and glucose concentrations in genetically lean or fat chickens. 670 57

Investigation of the relationship between relative body mass (RBM) of women immediately upon giving birth and birth weight (BW) of newborns showed that variables are positively correlated (r = 0.56, P less than 0.05). Data on distributions of adult RBM and BW show that it is more likely that children with a BW greater than or equal to 4.5 kg will become obese in a later stage of life than those whose BW was less than or equal to 3.2 kg. The regression lines in a group of children indicated a positive correlation between RBM and glycemia (r = 0.30, P less than 0.01), cholesterolemia (r = 0.223, P less than 0.05), and triglyceridemia (r = 0.239, P less than 0.05). After the same duration of dieting, those adults who became obese in early childhood lost as much from their initial body mass and fat as those who became obese in adulthood. A reducing diet produced a decrease in systolic and diastolic blood pressure in both groups, but was significant only in the latter. Therefore, the prevention of obesity and its consequences should begin in the intrauterine stage and be continued through early childhood, adolescence, and adulthood with dietary measures and increased physical activity.
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PMID:Childhood obesity as a risk factor in adulthood and its prevention. 684 17

The study aimed at establishing a risk for metabolic diseases in the randomly selected population in the age over 18 years, inhabitants of the little town in Siedlce Voivodeship. Using comparative tables, in was found that percent of women and men in the investigated group is similar to that in the population of this town. Women prevailed slightly in the investigated group which characterized also relatively low age (42 years) and low diastolic blood pressure. Obesity was found in 40% of the investigated subjects. Over 2.6% had diabetes mellitus and 11.4%--improper glucose tolerance (according to WHO criteria). Every fifth subject has blood lipids disorders. Such disorders were more frequent in the subgroup of men. Additionally, relationships between these findings were analysed. Body weight index markedly correlated with blood triglycerides level and less pronounced with blood total cholesterol and uric acid. Negative correlation between BMI and HDL cholesterol levels was noted. The lack of correlation between glycaemia, cholesterolemia and triglyceridemia results from the fact that there is such a correlation in men but not in women. The obtained results indicate the necessity of preventive measures.
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PMID:[Incidence of the most important metabolic disorders in the population of a little town in Poland]. 836 80


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