Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Exogenous obesity is characterized hemodynamically by expanded intravascular (plasma) volume associated with an increased cardiopulmonary volume and cardiac output. In contrast, essential hypertension is related to an increased total peripheral resistance that is more or less uniformly distributed throughout the component organ circulations associated with a contracted plasma volume in proportion to the height of arterial pressure. Thus, both cardiac output and total peripheral resistance are elevated in obesity hypertension, and both impose a load on the left ventricle, resulting in both a volume and a pressure overload left ventricular hypertrophy. Although renal vascular resistance is not as increased as it is in lean hypertensive patients, these patients are subjected to hyperfiltration and proteinuria. Additionally, these hemodynamic alterations coexist with carbohydrate intolerance, hyperinsulinemia, hyperlipidemia, and hyperuricemia. With weight reduction and associated pressure reduction, the hemodynamic and metabolic changes reverse toward normal. However, should this not be achievable, the angiotensin converting enzyme inhibitors and calcium antagonists provide rational physiological approaches to drug therapy. With these agents pressure reduction is achieved through a fall in vascular resistance without intravascular volume expansion, and this is associated with reduced left ventricular mass and preserved cardiac and renal function, and without exacerbation of preexisting metabolic perturbations. Hence, these two classes of antihypertensive agents may provide a rational and physiological means for reversing the pathophysiological alterations of hypertensive disease in those obese patients in whom weight control is not possible.
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PMID:Obesity hypertension. Converting enzyme inhibitors and calcium antagonists. 173 Apr 48

According to current statistics, there are, at an average child's general practice about seventy children registered with obesity, including fifty children indicated for long-term treatment of obesity due to medical indications, fifteen children are intended for targeted modifications in their diet, and in almost every practice there is a child with a pathognomonic obesity. Currently, we are exposed to food-borne pandemic coupled polygenic obesity, which is a chronic metabolic disease with societal consequences. Alimentary obesity mainly reflects an early onset of cardio-metabolic risk, but the clinical picture of complications of childhood obesity is broader and includes not only the risk of life-limitation, but also respiratory, gastrointestinal, neurological, orthopaedic and endocrine complications along with serious psychosocial problems. The effects caused by childhood obesity are reversible initially, and early identification and treatment is a major clinical challenge in preventing the development of serious metabolic, organ, psychological and societal complications.
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PMID:[Children obesity and its metabolic outcomes]. 2267