Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0028754 (
obesity
)
124,988
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Parastomal pyoderma gangrenosum
(
PPG
) is an unusual neutrophilic dermatosis characterized by painful, necrotic ulcerations occurring in the area surrounding an abdominal stoma. It typically affects young to middle-aged adults, with a slight female predominance. The underlying etiology for
PPG
remains enigmatic but aberrant immune response to injury may play a pivotal role. The reported risk factors for the development of
PPG
include the presence of extra-intestinal manifestations, autoimmune disorders and
obesity
, along with local factors, such as the presence of parastomal hernia or pressure ulcer.
PPG
can develop at any time after the stoma construction. The histopathological features of
PPG
are not pathognomonic and its diagnosis is mainly based on clinical features. The management of
PPG
often requires a multidisciplinary approach, with a combination of local wound care and systemic medications.
...
PMID:Diagnosis and management of parastomal pyoderma gangrenosum. 2475 61
