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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nutrition has always been a subject of great interest to athletes. In recent years use of exercise has, however, expanded from competitive sports to prevention/management of chronic diseases and maintenance of optimal health. Exercise is recommended in the prevention/management of noninsulin-dependent diabetes, hypertension, coronary heart disease, osteoporosis, obesity, mental health, colon cancer, stroke and back injury. Similarly, there is evidence that certain nutrients (e.g., vitamins C and E, beta-carotene and calcium) may reduce the risk of certain cancers, coronary heart disease, osteoporosis, hypertension and cataract. Thus, there seems to be concordance between the health benefits of exercise and certain nutrients. However, several human and animal studies suggest that strenuous exercise may promote free radical production, leading to lipid peroxidation and tissue damage. On the other hand, there is evidence that vitamins C and E and beta-carotene may protect against such damage. Thus, concordance between the health benefits of exercise and nutrition and a compensatory role of antioxidant nutrients against the potentially harmful effects of exercise suggests that nutrition and exercise should form important components of any regimen for prevention of chronic diseases and/or promotion of optimal health.
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PMID:A current perspective on nutrition and exercise. 154 45

To investigate an association between colon cancer and obesity during early adulthood--a potentially important period in the etiology of this disease--the authors assembled, by computer linkage, a population-based historical cohort of 52,539 men born between 1913 and 1927 residing in Hawaii (USA), for whom weight and height had been recorded in 1942-43 and 1972. Linkage of this cohort to the Hawaii Tumor Registry resulted in the identification of 737 incident cases of colorectal cancer for 1972-86. An average of 3.8 cancer-free controls were matched to each case on month and year of birth and ethnicity of the parents. A case-control analysis in each anatomic subsite of the large bowel revealed that both early and middle-age body mass increased the risk of sigmoid cancer in men in a dose-dependent fashion. The odds ratios (OR) for sigmoid cancer for the highest compared with the lowest tertiles of Quetelet index were: 2.1 (95 percent confidence interval [CI] = 1.4-3.2) and 1.7 (CI = 1.1-2.5), at ages 15-29 and in prediagnostic years, respectively. These associations were additive and independent of socioeconomic status. Men who were above the median Quetelet index in 1942 and 1972 had an OR of 2.7 (CI = 1.8-4.0), compared with those who were below the median in both periods. This study provides further evidence for an association of obesity with colon cancer in men and suggests that this association is limited to the sigmoid colon and may be related to both early and late events of colon carcinogenesis.
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PMID:Obesity in youth and middle age and risk of colorectal cancer in men. 161 22

Vigorous physical activity can improve the health of both adults and children. Among adults, regular physical activity can reduce risk for chronic diseases such as coronary heart disease, hypertension, noninsulin-dependent diabetes mellitus, colon cancer, and depression, as well as lower all-cause death rates (1,2). Among children, regular physical activity can reduce chronic disease risk factors such as obesity, elevated cholesterol, and hypertension (3). Physical activity patterns established during childhood may extend into adulthood (4). This report examines the prevalence of vigorous physical activity among U.S. students in grades 9-12.
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PMID:Vigorous physical activity among high school students--United States, 1990. 173 Nov 78

Approximately 34 million US adults were obese in 1980. Obesity is associated with increased risk of noninsulin-dependent diabetes mellitus (NIDDM), hypertension, cardiovascular disease, gallbladder disease and cholecystectomy, and colon and postmenopausal breast cancer. Using a prevalence-based approach to cost of illness, we estimated the economic costs in 1986 attributable to obesity for these medical conditions. Indirect costs due to morbidity and mortality were discounted at 4%. Overall, the costs attributable to obesity were $11.3 billion for NIDDM, $22.2 billion for cardiovascular disease, $2.4 billion for gall bladder disease, $1.5 billion for hypertension, and $1.9 billion for breast and colon cancer. Thus a conservative estimate of the economic costs of obesity was $39.3 billion, or 5.5% of the costs of illness in 1986. Addition of costs due to musculoskeletal disorders could raise this estimate to 7.8%. The costs of treatment for severe obesity must be weighed against the improved health status and quality of life.
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PMID:Economic costs of obesity. 173 19

Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incidence adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P = .02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer.
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PMID:Obesity and colorectal adenomatous polyps. 199 19

In Western societies, energy imbalance is characterized by obesity and sedentary life styles and is associated with increased morbidity and mortality from all causes of cancer, including cancer of the breast, colon and prostate. The interrelationships of energy intake and energy retention, to energy expenditure and physical fitness need further investigation from the physiologic, metabolic, endocrine and genetic aspects of cancer development, since obesity, energy expenditure and cancer have a familial predisposition. The effects of exercise on estrogen and prostaglandin metabolism and their relationship to cancer development require further investigation. Although the exact amount and intensity of exercise that confers benefit is not known, physical activity and physical fitness are inversely associated with all-cause mortality, including cancer. These findings have important public health implications, because about one-third of persons in industrialized societies are quite sedentary, and the prevalence of low physical fitness is quite high. The balance between total energy intake and expenditure may be more important in cancer development than the intake of any given dietary component or energy source. Exercise increases prostacyclin and decreases the aggregation of platelets and possibly decreases the platelet derived growth factors (PDGF). One could speculate that exercise may in turn decrease the probability of developing colon cancer in those who are predisposed to it, since the SIS oncogene is in fact a variant of PDGF.
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PMID:Energy imbalance and cancer of the breast, colon and prostate. 223 30

The current decade has witnessed an increasing interest in the diet-cancer issue as a central one for public health. Notwithstanding a substantial amount of epidemiological investigations, firm evidence of carcinogenicity exists only for alcoholic beverages with respect to cancers at several sites, and for aflatoxin with respect to liver cancer; also, the relation is established between diet related excess of energy intake, as translated into obesity, and cancer of endometrium and gallbladder. For a number of other dietary factors the evidence for a causal or protective role still remains at a presumptive level (e.g. intake of fresh vegetables and fruits with respect to cancers at several sites), or is still frankly open to debate (e.g. fat with respect to breast and colon cancer). Methodological inadequacies in past studies have been identified and clearer results should derive in the coming decade from epidemiological investigations substantially improved in methodology, particularly from the long-term prospective studies as now planned by the International Agency for Research on Cancer. Fortunately for cancer prevention, such dietary advice as can be derived from the highly incomplete and unsatisfactory knowledge on the role of dietary factors on cancer, turns out to be in broad agreement with the advice aimed at preventing other major diseases such as ischaemic heart disease and hypertension. This allows the issuing of a set of simple but important 'prudent diet' recommendations.
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PMID:The diet and cancer hypothesis: current trends. 223 43

A rising incidence and mortality rate from cancer of the colon and rectum has been observed in some Chilean regions. An estimated 1.350 hospital admissions and 650 deaths occurred in the last decade. Cumulative risk for developing these lesions is estimated at 0.75% under 60 and 1.52% under 75 years of age. Mean age at presentation was 65 years for colon cancer and 63 for cancer of the rectum. Both sexes were equally affected. Valid survival studies are not available in Chilean literature. The relation of number of deaths and admissions per year was 78.5% for colon cancer and 28.9% for the rectum. From 1965 to 1985 an 83% increase in the prevalence of rectum cancer and 7% for colon cancer was observed. This trend was most marked in the Magallanes region. A family history appears as a significant risk factor (1.4 to 49.1 odds ratio). Borderline significance as risk factors was observed for obesity and meat and relish consumption. No effect of smoking, alcohol intake, history of lithiasis or exposure to asbestus or ionizing radiation was observed.
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PMID:[Colon and rectum neoplasms in Chile: epidemiological characteristics]. 251 24

The relationship between cholecystectomy and subsequent development of colon cancer was investigated in a case-control study of 165 patients with histologically proven adenocarcinoma of the colon. These patients were from a community in Iowa where incidence of colon cancer was considered to be higher than average in the United States. The relative risk of developing colon cancer after cholecystectomy was shown to be 2.11 (P = .009) for the entire series and 2.91 (P = .002) for the female group. There was a difference of frequency in developing colon cancer after cholecystectomy between the right- and left-sided colons; the relative risk of the right versus the left colon cancer was 2.31 (P = .019). The other factors, including blood group, red cell indices, obesity, serum cholesterol, colonic diverticula, and co-existence of hyperplastic or adenomatous polyp disclosed no significant relation to colon cancer developed after cholecystectomy.
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PMID:The relationship between cholecystectomy and colon cancer: an Iowa study. 272 85

It is the totality of the evidence that links a high level of dietary fat to risk for breast and colon cancers. The evidence is built on descriptive epidemiology, correlation studies, migrant studies, time trends, case-control studies, metabolic epidemiology, experimental animal studies, and biological plausibility. The effects of total caloric intake or of obesity are not as relevant as the specific types and amounts of fat consumed. The effects of fiber in modulating colon cancer risk are inconsistent. This may be due, in part, to the varying effects of differing fibers. The key questions are, which fats and which fibers, and what amount of each, are of etiological and preventive significance?
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PMID:Amount and type of fat/fiber in nutritional carcinogenesis. 281 46


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