Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nondrug measures have proven effective, to some extent, in lowering blood pressure, especially in mild hypertensives, in many well-controlled studies. The proven measures are reduction of a) salt (less than 5 g/day), b) alcohol (less than 30 ml/day) intake, and c) obesity, and d) regular physical exercise (30-60 minutes/day) and e) mental relaxation. The reported effectiveness of each of these measures ranges from one third to two thirds in mild hypertensives. Should all these nondrug measures, together with cessation of smoking, be applied in all mild hypertensives, it might help prevent their progression to moderate or even severe hypertension with complications, such as coronary heart disease in particular, thereby solving most of the problems that antihypertensive drugs have left behind.
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PMID:Non-pharmacologic measures for lowering blood pressure. 203 35

Metabolic syndrome, a cluster of metabolic abnormalities with visceral obesity and insulin resistance as its central component, is highly prevalent among hypertensive patients. Hypertension complicated by metabolic syndrome is associated with an increased risk of cardiovascular disease and new-onset Type II diabetes mellitus that further aggravates the prognostic outlook. Such a complex condition requires a multifactorial intervention including blood pressure lowering, improvement of the adverse metabolic profile and delayed onset of new diabetes. In this respect, doxazosin and other alpha-1 adrenoceptor blocking agents are of interest given their effect on the lipid profile in dyslipidemic, obese hypertensive patients, either diabetic or not. Doxazosin improves insulin sensitivity, apparently by accelerating insulin and glucose disposal through vasodilatation of skeletal muscle vascular beds. Whether long-term treatment with the drug might delay, or possibly prevent, incident Type II diabetes in hypertension complicated by metabolic syndrome is an intriguing possibility to be tested in appropriately designed clinical trials.
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PMID:Doxazosin in metabolically complicated hypertension. 1803 18