Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cushing's syndrome is characterized by protein wasting secondary to hypergluconeogenesis, which produces thin skin, poor muscle tone, osteoporosis and capillary fragility. These features distinguish patients with true Cushing's syndrome from those who have some of the clinical findings often associated with the syndrome, such as obesity, hypertension, striae and hirsutism. The dexamethasone suppression test helps identify patients with pseudo-Cushing's syndrome.
 ...
PMID:'Not Cushing's syndrome'. 22 Aug 64

The common obesity of middle age presents a set of features that strongly resembles the cardinal symptoms of Cushing's syndrome: obesity of the face (moon face), upper back (buffalo hump) and trunk (pot belly) accompanied by signs of protein-wasting. In non-obese individuals who remain at a constant weight throughout life, the proportion of adipose tissue increases with age at the expense of lean tissue loss. Thus, a mild version of Cushing's syndrome may be part of the normal aging process. A more intense version of this process may occur in overweight adults. Excess and chronic activity of two pituitary hormones may contribute to this adiposity. Both hormones are produced in the same pituitary cell by cleavage from a common large precursor known as pro-opiocortin. One hormone is adrenocorticotrophin (ACTH), which stimulates the release of the glucocorticoid hormones. These hormones promote the conversion of bodily proteins to glucose (gluconeogenesis). The other pituitary hormone is beta-endorphin, a stimulant of appetite that causes the release of insulin. This pancreatic hormone promotes the conversion of glucose and fatty acids to triglycerides (lipogenesis). Three different etiologies are suggested for the excessive and chronic action of these two pituitary hormones: tumors that increase the number of cells that synthesize pro-opiocortin; mutant strains that produce excessive amounts of ACTH and beta-endorphin such as the genetically obese mouse (ob/ob) and rat (fa/fa); and an age-determined shift in the type of cleavage enzymes present in the pro-opiocortin cell that favors ACTH and beta-endorphin production.
 ...
PMID:The obesity of middle age: a common variety of Cushing's syndrome due to a chronic increase in adrenocorticotrophin (ACTH) and beta-endorphin activity. 22 74

In representative series of Sout African Black, Indian and White High School pupils of 18 years, data were secured on weight, height and triceps skinfold. Values among Black boys were significantly lower than those among White boys. Yet, obesity was far commoner among Black compared with White girls. Among Indian pupils, there were no significant differences in mean anthropometric values between groups relatively affluent and relatively poor. Values on Indian boys were similar to those of Black boys, although the former were far more favourably placed socioeconomically. Indian girls, compared with Black girls, had highly significantly lower values for weight and skinfold thickness, but not for height. However, mean weight for height values for Black and Indian boys were similar to values for White boys. Weight for height values for Indian girls were similar to data for White girls, although values on these two ethnic groups were significantly lower than those for Black girls. Findings question the insistence by many (i) of the need to attain maximum potential growth, and (ii) apart from extreme wasting and stunting, of the need to conform to international growth standards.
 ...
PMID:Weight, height and triceps skindfold in South African black, Indian and White School pupils of 18 years. 89 64

To evaluate the impact of urban life-style on nutritional status, body mass index (BMI) of mothers and indices of malnutrition of preschool children were calculated in four representative surveys in two rural areas and two main cities of Western and Central Africa. Mean BMIs were similar in both urban settings and were significantly higher than those of rural mothers. Distributions shifted significantly towards values over 25 kgs/m2 in towns, although, values lower than 18.5 were still present. Therefore chronic energy deficiency, largely prevalent in many rural areas of Africa, remains important in cities, where obesity also appears to have become a public health concern. Wasting was rare in young urban children, but the prevalence of stunting, although lower, indicates the persistence of nutritional deficiencies. This situation of nutritional transition generates a double burden to already limited health finances and requires an appropriate educational policy.
 ...
PMID:[Urbanization and nutritional transition in sub-saharan Africa: exemplified by Congo and Senegal]. 146 32

The general health and nutritional status of 105 refugee children from Chile and the Middle East were examined shortly after the arrival in Stockholm. A chronic medical condition was present in 10% and there were clinical signs of caries in 57% of the children. Iron deficiency was found in 15% of Chileans and 6% of Middle Easterners, but no other nutritional deficiencies were discovered. Stunting and wasting was rare and a significant catch-up growth was observed in both groups in a follow-up 18 months after resettlement. Obesity was common in the Chilean group on arrival in Sweden and increased further after resettlement. We conclude that chronic medical conditions, caries and obesity were the major somatic health problems in this sample of newly resettled refugee children.
 ...
PMID:Health and nutrition in newly resettled refugee children from Chile and the Middle East. 195 7

The nutritional status according to anthropometric data was assessed in 756 schoolchildren from 5 low-income state schools and in one private school in the same part of Rio de Janeiro, Brazil. The prevalence of stunting and wasting (cut-off point: less than 90% ht/age and less than 80% wt/ht) ranged in the public schools from 6.2 to 15.2% and 3.3 to 24.0%, respectively, whereas the figures for the private school were 2.3 and 3.5%, respectively. Much more obesity was found in the private school (18.0%) than in the state schools (0.8-6.2%). Nutritional problems seem to develop more severely in accordance with the increasing age of the children. Therefore it appears advisable to assess schoolchildren within the context of nutritional surveillance system.
 ...
PMID:The relationships between selected anthropometric and socio-economic data in schoolchildren from different social strata in Rio de Janeiro, Brazil. 221 71

Presented are the results of the anthropometric component of the 1985 Andalusian Nutritional Survey. The heights and weights of a representative sample of children aged 6-60 months were compared with data for the National Center for Health Statistics/Centers for Disease Control (NCHS/CDC) reference population. Of the 1181 preschool-age children surveyed, the great majority fell within +/- standard deviation (SD) scores for height-for-age (93.6%) and weight-for-height (93.5%), and most (87.7%) were within +/- 2 SD scores of the mean value for the NCHS/CDC reference population for both height-for-age and weight-for-height. The proportion of stunting was 3.2%, that of wasting 1.0%, and that of both stunting and wasting 0.4%. For both sexes, the distribution of height-for-age was comparable with that of the NCHS/CDC reference population, while that for weight-for-height was skewed to the right. This suggests that for the same height, the weight of Andalusian children increased more over the 5 years preceding the survey than that of the reference population over the period 1971-74. The data obtained could be used as a baseline to evaluate the effectiveness of future nutrition programmes for children who are at a high risk of undernutrition or obesity.
 ...
PMID:The Andalusian Nutritional Survey: comparison of the nutritional status of Andalusian children aged 6-60 months with that of the NCHS/CDC reference population. 280 18

Destruction of the ventromedial hypothalamus produces hyperphagia, hyperinsulinemia and hypertriglyceridemia. These changes appear to be partly the result of increased firing rate of the vagus nerve and reduced firing rate of the sympathetic nerves. These reciprocal changes in the function of the autonomic nervous system appear to provide an adequate explanation for the hyperinsulinemia in this syndrome, and for the reduced heat expenditure. Destruction of the lateral hypothalamus, has effects opposite to those of the ventromedial hypothalamus with a reduction in food intake, a decrease in body fat, and an increase in the activity of the sympathetic nervous system. These reciprocal functions of the hypothalamus are associated with different adrenergic receptors. A medial hypothalamic alpha-adrenergic system mediates the epinephrine stimulation of feeding, and a beta-adrenergic system mediates the lateral hypothalamic inhibition of eating. Peptides from the endorphin family can stimulate food intake, but most other peptides are inhibitory. Growth hormone and thyroid hormone stimulate food intake under appropriate conditions. Insulin and adrenal steroids appear to play the most important role of all the hormones in regulating food intake. Deficiency of adrenal glucocorticoids is associated with decreased food intake and a wasting of body flesh. Increased levels of glucocorticoids, on the other hand, produce a variety of truncal obesity. In animals with ventromedial hypothalamic lesions and obesity, adrenalectomy will reverse the obesity. In genetically obese rats and mice, adrenalectomy will attenuate the progression of the syndrome. These effects appear to be through a reduction of food intake, and an increase in energy expenditure. Injections of insulin will stimulate food intake and may lead to obesity.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Autonomic and endocrine factors in the regulation of food intake. 286 66

In some child populations, low height-for-age, suggesting chronic undernutrition, may paradoxically be accompanied by relatively high weight-for-height, suggesting obesity. This growth pattern was investigated with anthropometric assessment and body composition studies using H2(18)O stable isotope dilution in 139 preschool-age Peruvian children. Results suggested low height-for-age (15th percentile National Center for Health Statistics [NCHS]) and high weight-for-height (60th percentile NCHS). Skinfold thicknesses were lower whereas arm muscle areas were more similar to NCHS reference values. Total body water (as percent body weight) was greater than reference values, consistent with lower body fat. Differences in body proportions did not account adequately for the high weight-for-height. The data suggest that the high weight-for-height in these children is not obesity but is associated with lower body fat and greater lean tissue or lean tissue hydration that may reflect dietary, environmental, or genetic influences. Weight-for-height cutoffs for wasting or obesity may require different interpretations for different populations.
 ...
PMID:Body composition of Peruvian children with short stature and high weight-for-height. II. Implications for the interpretation for weight-for-height as an indicator of nutritional status. 363 Sep 60

1 The sympathetic noradrenergic activation of brown adipose tissue and the biochemical mechanisms involved in diet-induced thermogenesis were studied in rats. 2 A close correlation was found between brown adipose tissue Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) activity in vitro and in vivo measurements of resting oxygen consumption (VO2). The effects of noradrenaline on in vitro NA+, K+-ATPase activity in brown adipose tissue and in vivo VO2 could be mimicked by a variety of agents. These included beta-adrenoceptor agonists and agents known to induce the release of noradrenaline or inhibit the noradrenaline uptake process. The pharmacological evidence suggests that dopaminergic mechanisms may also be involved in the control of thermogenesis. 3 Amphetamine did not increase VO2 in rats without causing associated increases in locomotor activity. Ciclazindol at doses of 3-30 mg/kg intraperitoneally increased VO2 but did not appear to increase locomotor activity or evoke any other signs of CNS stimulation including lengthening of time to sleep onset or stereotypy. Separation of metabolic and CNS effects occurred only at the lowest dose of mazindol used (0.3 mg/kg i.p.). These results are probably a reflection of (a) the relative abilities of these drugs to inhibit brain and brown adipose noradrenaline uptake processes and (b) the relatively high accumulation of ciclazindol in brown adipose. 4 Of the drugs tested, only ciclazindol was a more potent inhibitor of the noradrenaline uptake system in brown adipose tissue (BAT) than in brain. Kinetic analysis also revealed that the actions of ciclazindol on the NA uptake system and Na+, K+-ATPase in BAT differed from those of mazindol. 5 These findings suggest that ciclazindol may produce an energy wasting effect in rodents without causing overt CNS stimulation; the implications of these findings in terms of human obesity are discussed.
 ...
PMID:Sympathetic mechanisms in diet-induced thermogenesis: modification by ciclazindol and anorectic drugs. 627 18


1 2 3 4 5 6 7 8 9 10 Next >>