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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy one patients with hypersomniac paroxysms--Pickwickian and Kleine-Levin syndromes, were studied, the incidence of combination of hypersomnia and obesity--followed up. They are supposed to have common pathogenetic mechanisms, giving weight to lesions of hypothalamo-reticulo-limbic structures in viral infections, craniocerebral traumas, intoxications and tumours. The pathological processes advanced in the reticulo-hypothalamo-hypophyseal region lead to hormonal regulatory disorders and disturbances in adaptation and compensatory mechanisms of metabolism, of lipid metabolism including, of sleep and vigilance. A schematic central explanation of the inter-relations of obesity and hypersomnias is presented.
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PMID:[Obesity and hypersomnia]. 371 66

A 9 1/2-year-old Taiwanese boy with Prader-Willi syndrome had the following characteristics: difficulties with sucking, feeding and hypotonia during infancy, a dysmorphic face (triangular mouth, high arched palate, almond-shaped eyes and large head circumference with a relatively narrow bifrontal diameter), borderline intelligence, hypogonadism, hyperphagia, skin picking and truncal obesity. The boy experienced two hypersomnia episodes, at age 8 and 9 years, with both episodes lasting for 10 days. During the two episodes, he was found to have an exacerbated case of hyperphagia, pica, poor emotional control, stereotyped speech and agitated behavior upon awakening. After each episode, the boy had complete remission. Our findings show that the two episodes are compatible with Kleine-Levin syndrome. The relationship between the two syndromes, the Prader-Willi syndrome and the Kleine-Levin syndrome, deserves further study.
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PMID:Kleine-Levin syndrome in a boy with Prader-Willi syndrome. 865 Apr 57

Excessive sleepiness is a common problem, defined by a complaint of excessive daytime sleepiness almost daily with an inability to stay awake and alert dosing periods at sleep, with episodes of irresistible sleep need or drowsiness or non-intentional sleep, or by a night's sleep time overly extended often associated with sleep inertia. This sleepiness is variable in terms of phenotype and severity to be specified by the out-patient clinic. It is considered to be chronic beyond three months and often responsible for significant functional impairment of school and professional performance, of the accidents and cardiovascular risk. We need to decipher the causes of excessive sleepiness: sleep deprivation, toxic and iatrogenic, psychiatric disorders (including depression), non-psychiatric medical problems (obesity, neurological pathologies...), sleep disorders (as for example the sleep apnea syndrome), and finally the central hypersomnias namely narcolepsy type 1 and 2, idiopathic hypersomnia, and Kleine-Levin syndrome. If careful questioning often towards one of these etiologies, need most of the time a paraclinical balance with a sleep recording to confirm the diagnosis. Patients affected with potential central hypersomnia must be referred to the Sleep Study Centers that have the skills and the appropriate means to achieve this balance sheet.
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PMID:[CLINICAL INVESTIGATION OF AN EXCESSIVE SLEEPINESS COMPLAINT]. 2753 25