Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In accordance with the recent amendment of the Ordinance on Occupational Safety and Health, anemia (Hb, RBC), liver function (GOT, GPT, gamma-GTP), serum lipid levels (T-Chol, TG) and ECG have become essential items of the general periodic health examination. Data on these items were examined on 86 employees on whom chest radiography, blood pressure, urinalysis and past history revealed no abnormalities in periodic health examination at their companies. The subjects were 58 males and 28 females, between 34 and 66 years old (47.6 years on average). Anemia was found in 3 (3.5%), liver dysfunction in 13 (15.1%), abnormal serum lipid levels in 24 (27.9%) and ECG abnormalities in 8 (9.3%). The new periodic health examination system is thus thought to be useful in the early detection and prevention of adult diseases. To enhance this utility, it appears important to instruct those found abnormal in any parameter to have extensive examination. In discussing liver function and serum lipid level abnormalities, obesity, drinking and food intake should be considered.
 ...
PMID:[A study on medical examination items added to periodic health examination as a result of amendment of the Ordinance on Occupational Safety and Health]. 834 66

The purpose of this study was to investigate the relation between body weight reduction and some complications associated with obesity. The subjects were 248 middle-aged obese persons (male 37, female 209) who participated in a weight reduction program at the Aichi Prefectural Center of Health Care from 1983 to 1990. The subjects had no severe complication, and the obesity indexes of all of them were over 120%. The program was held monthly for five months and consisted of diet (1500 kcal/day) and exercise (10000 walk steps/day). After the program, mean obesity index decreased by about 9%, and mean body weight reduction was about 5kg. Blood pressure, total cholesterol, triglyceride and GPT were significantly decreased, and HDL cholesterol was slightly increased. For each item the percentage of persons with abnormal values reduced by about 5 to 20%. From the relationship between degree of decrease of obesity and changes of the values of each item, it was estimated that some complications of obesity require greater than 5 to 10% decrease in obesity index to be affected. The value of each examination item before the program and the degree of decrease of obesity index had an effect on changes of the values, but obesity index before the program and age had little effect.
 ...
PMID:[Effect of body weight reduction on blood pressure and biochemical data]. 852 48

To determine hepatic diseases in obese children, biochemically and histologically, 11 obese patients with abnormal serum transaminase activities were subjected to this study. Fat accumulation in the liver was semiquantitatively graded, and histologically the 11 patients were classified into four groups; fatty liver, fatty hepatitis, fatty fibrosis and fatty cirrhosis. All patients had fat deposition in liver specimens, the grade of which did not significantly correlate with the degree of obesity. The grade of fat deposition in the liver specimens also did not significantly correlate with either serum transaminase activities or GOT/GPT ratio. Five patients were grouped into the fatty liver group, three into the fatty hepatitis group, and the remaining three patients into the fatty fibrosis group. However, no significant differences were found among the three histologically classified groups in terms of serum transaminase activities or GOT/GPT ratio. The usefulness of serum transaminase activities and GOT/GPT ratio was limited in predicting the severity of fat deposition or histological abnormality in pediatric obese patients.
 ...
PMID:The relationship between serum transaminase activities and fatty liver in children with simple obesity. 853 91

We investigated the factors which may influence post-operative liver and renal function using a multiple regression analysis after isoflurane or sevoflurane anesthesia in 844 patients (ASA I or II, age 20-90 yr). Hepatic and renal surgeries were excluded from this study. The parameters examined were sex, age, degree of obesity, preoperative liver function, preoperative renal function, infection with hepatitis B or hepatitis C virus, inhalation anesthetics used, MAC.h of anesthesia, the duration of operation, blood loss, amount of blood transfusion, urine volume during operation, and surgical site. Serum GOT, GPT, total bilirubin, BUN and serum creatinine were examined on the 3rd and 7th day after surgery. An increase in serum GOT, GPT or bilirubin was observed for each of the following parameters; male, infection with hepatitis C virus, long operation, and upper abdominal surgery. Postoperative BUN and serum creatinine increased in patients with preoperative renal dysfunction, in elderly patients, and in hepatitis C carriers.
 ...
PMID:[Multiple regression analysis of pre- and intra-operative factors in relation to post-operative liver and renal functions]. 854 85

A total of 34,000 adults in Fukui City who had participated in annual health examinations at least once between 1986 and 1988, were followed for a period of 5 years. The results were as follows; (1) The mortality rate during a 5 year period was significantly lower for participants in health examinations than in nonparticipants of the same age group. (2) Mortality was significantly related to obesity, systolic and diastolic blood pressure, glucosuria, proteinuria, occult blood in urine, GOT and cholesterol in man, in women obesity, systolic and diastolic blood pressure, glucosuria, proteinuria, GOT, GPT and cholesterol were related to mortality. (3) An increase in hazard ratio with increasing degree of thinness was suggested particularly in males. (4) Hazard ratios increased with decreasing cholesterol in both men and women combined. (5) Except for hypertension which increased risk for circulatory disease, none of the above data appeared to be related to specific causes of death.
 ...
PMID:[Relationship between participation in annual health examinations and mortality rate over a 5-year period]. 867 9

To evaluate the relationship between working conditions and workers' health, particularly the effect of work-related stress with change of working conditions for those with alcohol drinking habit and liver disorder, we analyzed physiological examination data and a questionnaire survey including the Japanese version of Karasek's Job Content Questionnaires (JCQ) on work-related stress, working hours, sleeping hours, alcohol consumption and cigarette smoking among male workers of a car manufacturing plant, who engaged in car sales work temporarily and then returned to manufacturing work. In the physiological examination data, the values of body mass index (BMI), GOT, GPT, gamma-GTP, TG and T-CHO rose and the prevalence of obesity and liver disorder increased during the term of car sales work. Comparing the term of car sales work with the term of car manufacturing work, the number of habitual drinkers and heavy smokers increased during the former and decreased during the latter. Increased alcohol consumption and cigarette smoking were also noted during the term of car sales work. Logistic regression analysis showed that the odds ratio of decreasing 'decision latitude (DL)' as work-related stress was statistically significant for increased alcohol consumption. The increased alcohol consumption probably contributing to the prevalence of liver disorder was assumed to be associated with work-related stress due to change of work conditions. Workers who showed liver disorder strongly complained of work-related stress, and it was assumed that the work-related stress was related to liver disorder. Longitudinal observations which take into account work-related stress, alcohol drinking habit and liver disorder must be well planned and personal traits of work-related stress always be taken into consideration.
 ...
PMID:[The effect of work-related stress with change of working conditions for workers with alcohol drinking habit and liver disorder]. 869 34

To examine the effect of weight changes on serum transaminase activities, glutamic oxaloacetic and pyruvic transaminases (GOT/GPT), a 3-month observation of 110 obese outpatients treated by a mild regimen for obesity was carried out. Patients were divided into two major groups, group I (n = 73) and group II (n = 37), with or without persistent elevation of serum GOT/GPT (> 30 IU/L), and retrospectively classified into four subgroups according to weight changes: group A, weight loss > 5%; group B, weight loss of < 5%; group C, an increase of < 5%; group D, an increase > 5%. In group IA, the incidence of cases with normalization of serum GOT/GPT was 70% and was significantly greater than those of the other three subgroups, respectively (P < 0.01). The incidences of decreased serum GOT/GPT activities were observed corresponding to the degree of weight changes not only in group I (100-27%) but also in group II (100-33%). These facts indicate that a mild regimen for obese outpatients for 3 months, significantly improves serum transaminase activities in patients not only with weight reduction but also weight gain, and that fatty liver may be present even in obese children with normal serum transaminase levels. The normalization of serum GPT activity in patients with weight gain suggests the presence of another factor contributing hypertransaminasemia in pediatric obese patients.
 ...
PMID:Effect of weight changes on serum transaminase activities in obese children. 914 Dec 56

We created a predictive model for the area under the concentration versus time curve (AUC) of cyclosporin A (CsA) using routine monitoring results, and examined its clinical utility. Based on 48 clinical time courses accumulated from renal transplant patients, the AUC predictive model was created. An estimate of the AUC0-8 (integrated from time zero to 8 h) was then given as follows: AUC0-8 = 5673.1 x log(TL) + 9342.8 x log(OB) + 64.1 x Dprd x 869.4 x DTK - 168.9 x HCT - 161.2 x SCr - 11.3 x GPT + 3.0 x PL - 588.6 x SEX - 24794.5. In this model, the AUC0-8(ng.h/ml) is given as a function of the CsA through levels (TL, ng/ml), obesity (OB, %), daily dose of prednisolone (Dprd, mg/d), donor type of kidney (DTK), hematocrit (HCT, %), serum creatinine (SCr, mg/dl), glutamate-pyruvate transaminase activity (GPT, IU/l), plasma lipids (PL, mg/dl) and sex distinction (SEX). The Statistical significance of the multiple regression was p < 0.00001 (R2 = 0.862, n = 48), and the day after transplantation, neither the administered oral dose of CsA, or the patient's age had any contribution to the regression. The predictive performance of this model was almost equal to that of the existing method which used 3-point data on the concentration versus time curve. In clinical adaptation for renal transplant patients, the steady-state concentration of CsA (Css) based on the AUC0-8 predictive model was significantly decreased during acute gastroenteritis or before acute rejection, whereas nephrotoxicity was increased, even though CsA trough levels were within a normal therapeutic range (100-200 ng/ml). These findings suggest that the created AUC0-8 predictive model using routine monitoring results, i.e., the trough level of CsA, biochemical tests, a daily dose of predorinsolone (PRD), and basic patient information, is convenient as a monitoring device for CsA therapy, and is satisfactory in clinical practice.
 ...
PMID:A predictive model for area under the concentration versus time curve of cyclosporin A using several routine monitoring results in renal transplant patients. 930 Jan 38

The relationship between the GOT/GPT ratio in nonviral liver disorders and underlying physical condition and life-style were evaluated. The subjects were 12,808 male railway company workers who underwent an annual health checkup. Nonviral liver disorders were defined as elevated transaminases (GOT > 76 IU/liter or GPT > 86 IU/liter, while negative for hepatitis B and C markers (282 cases). Controls were 9,783 males with normal findings for GOT, GPT, and y-GTP. By logistic regression analysis, GOT-dominant liver disorders were significantly related to alcohol consumption, hypertriglyceridemia, and diabetes mellitus. They were still significant on multivariate analysis. GPT-dominant liver disorders were significantly related to obesity, less exercise, hypercholesterolemia, and hypertriglyceridemia. Obesity and hypercholesterolemia were significant on multivariate analysis. In conclusion, the relationship between hypertriglyceridemia or diabetes mellitus and GOT-dominant disorders, which was not explained empirically, could indicate another pathogenesis for nonviral liver disorders, such as underlying insulin resistance.
 ...
PMID:Various S-GOT/S-GPT ratios in nonviral liver disorders and related physical conditions and life-style. 1191 40

The influence of the "shukko" (temporary transfer) work system on health was examined. "Shukko" is a Japanese individual work system. The life-time employment system was general in Japan. "Shukko" work system was devised to reduce the number of personnel in Japan. "Shukko" personnel belong to their present company but they must do the work of another company. Generally, the disadvantages of "shukko". Personnel are greater than in former "shukko" The subjects are 483 office workers in a certain industrial company. 143 workers work in a subsidiary of this company (Age: 42.2 +/- 5.5) (strategic shukko group), 30 workers work in the other company, having resigned their administrative post in the head office (55.6 +/- 2.1) (Demotion by the manager shukko group), and 310 workers work in the head office of this company (41.8 +/- 5.2) (head office working group). The medical examination results (degree of obesity, systolic blood pressure (SBP), GPT, GGTP, total cholesterol, triglyceride (TG), fasting blood sugar (FBS), uric acid (UA), electrocardiography (ECG), and gastrography were compared by mean of multiple regression analysis. In the "Demotion by the manager shukko" group, the average age and SBP were higher than in the other groups. (p < 0.0001). The "strategic shukko" group was compared with the "head office working" group. There is no significant difference in average age. The average SBP (p < 0.001) and FBS (p < 0.0001) of the "head office working" group was significantly higher than those of the "strategic shukko" group. ECG findings were more serious in the "Demotion by the manager shukko" group than in the other groups (p < 0.0001). There is a significant correlation between SBP and "degree of obesity, FBS and UA" (p < 0.0001). There is significant correlation between FBS and "GGTP, SBP, UA, GPT and TG" (p < 0.0001). And there is significant correlation between ECG findings and "working form and SBP" (p < 0.05). The prevention and early diagnosis of geriatric diseases is important for the "Demotion by the manager shukko" group, and their average age is older than that of the other groups. A problem with the head office working group is obesity. In this group it is important to take into consideration life related diseases. The workers complaint a lot in the "strategic shukko" group, but there are no abnormal findings. We think that their complaints are due to their mental stress. In this group measuring mental stress is important.
 ...
PMID:[Investigation of the health condition of the "shukko" person in a certain Japanese company]. 1251 34


<< Previous 1 2 3 4 Next >>