Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Post-mastectomy lymphedema of the upper limb, that can be noticed by 10 to 20 percent of patients with breast cancer, is usually related to some risk factors: use of radiotherapy on the axilla, obesity, venous outflow obstruction, delayed wound healing or infection. The most important contributing factor to postsurgical edema is the development of lymphangitis in the upper limb. Although literature contains numerous accounts on the use of pharmacological agents for the treatment of postmastectomy lymphedema, the results are not satisfactory in term of clinical response and side effects. In the present study we investigate tolerability and feasibility of the use of suledexide in patients, submitted to mastectomy for breast cancer, with an initial lymphedema of the limb omolateral to surgery or other risk factors for the development of a clinical remarkable lymphedema. Our results show that sulodexide is a very satisfactory therapy in term of lack of side effects and good compliance.
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PMID:[Sulodexide in the prevention of post-mastectomy lymphedema]. 767 95

Disturbing lymphedema of the related arm occurs in 20 to 30 per cent of patients after conventional mastectomy.Infection, obesity and radiation therapy are the most important contributing factors in the development of swollen arm. Continuous suction drainage of the wound and the use of antibiotics will reduce the incidence of infection. Lymphangiosarcoma is a rare fatal complication of postmastectomy lymphedema.
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PMID:Postmastectomy lymphedema. 1360 93