Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The current view that the morbidly obese do not show a unique personality pattern is challenged. A sample of 91 obese female patients at a general practice are identified as having a significant personality pattern using the Sixteen Personality Factors Questionnaire (16 PF) and the Neuroticism Scale Questionnaire (N.S.Q.). Further the personality factors are consistent with a model that explains aspects of morbid exogenous obesity.
 ...
PMID:Personality of a group of grossly obese women. 28

Risk factors were compared in 300 patients with brain stroke and 120 patients with neurosis or sciatic pains. It was found that arterial hypertension (p = 0.001) and diabetes (p = 0.01) were significantly more frequent in cases of brain stroke. Disturbances of lipid metabolism, tobacco smoking and obesity showed no significant difference. Extracerebral atherosclerosis (p = 0.001) increased the risk of stroke. Coronary arterial disease was most frequent (48.8%), myocardial infarction (8.3%) and calcifications in the aorta (32%) were second and third in frequency. Presence of at least two risk factors may be an indication to prophylactic treatment.
 ...
PMID:[Risk factors in stroke]. 72 25

The obesity belongs to the diseases with a great socio-medical importance. 75 patients with obesity were examined by means of the psychopathological short-time method issued by Hennig and Mehl, which was developed from Kincannon's mini-mult. Here in 30 obese patients (ca. 40%) increased values in at least one clinical scale appeared, which may be estimated as a reference to a neurotic mode of behaviour. Thus, neurotic modes of behaviour seem to appear more frequently in patients with obesity than in the average population (10%), however, more infrequently than in essential hypertonics (70%). Neurotic (Broca index + 30 kg) and non-neurotic (Broca index + 29 kg) patients with obesity had on an average the same overweight.
 ...
PMID:[Psychological studies on adipositas]. 91 May 23

It has been well known that the fasting therapy which was invented in Medical School of Tohoku University reveals an excellent effect upon various kinds of psychosomatic diseases, but its therapeutic mechanism and suitable indication are not yet explained completely. In order to corroborate these problems, this study was undertaken on 262 cases of psychosomatic diseases in the field of internal medicine. It is a complete fasting for 10 days with nothing by mouth except for drinking water, and 500 ml of parenteral fluid containing vitamins are administered intravenously every day. Absolute bed rest and self meditation are required in a closed individual room, and patients are not allowed to meet anyone but physicians and nurse in charge. The return to normal ordinary diet follows the order of fluid diet, soft diet and semiordinary diet during 5 days. In the period of the therapy, various clinical and laboratory examinations were carried out. Significance of these examinations consists in prediction of possible danger during the fasting period and elucidation of its therapeutic mechanism. Consequently, an outstanding efficacy rate of 87% with excellent prognosis was attained, and the following diseases were determined as suitable indication of this therapy; irritable colon, dysorexia nervosa, borderline hypertension, neurocirculatory asthenia, bronchial asthma, mild diabetes mellitus, obesity, lumbago without organic findings, conversion hysteria, various neurosis with somatic symptoms and masked depression. Possible mechanism of action of the therapy is that fasting acts as an extreme stress on the function of the autonomic nervous and endocrine systems, then it regulates the function of whole body including the brain, also it acts as one of the behaviour therapy for abnormal conditioning.
 ...
PMID:Fasting therapy for psychosomatic diseases with special reference to its indication and therapeutic mechanism. 96 29

As part of a general health survey of a small New Zealand town, the Crow-Crisp Experiential Index, the State-Trait Anxiety Inventory, a shortened version of the Hostility and Direction of Hostility Questionnaire, and the Zung Self-rating Depression Scale were administered to 1173 subjects over the age of 15. Blood pressure was moderately correlated with age and Quetelet's Index, a measure of obesity. Low but significant correlations were found between Somatic Anxiety, Hysteria, and the Urge to Act-out Hostility scale. However, when effects of age were controlled for, in a series of multiple regression analyses, the correlations with psychometric test scores were no longer significant. This study confirms several previous reports that neuroticism, anxiety, depression, and hostility are of little significant in predicting levels of blood pressure in the general population.
 ...
PMID:The relationship between blood pressure and personality in a large unselected adult sample. 373 80

The results of a survey carried out in Marseilles between 1972 and 1979 are reported. A common protocol was used to compare results with two other surveys performed conjointly in Paris and Brussels. The protocol was designed with special emphasis on the psychological factors with respect to the risk factors for ischaemic heart disease (IHD). Seven hundred and eighty six men in a Marseilles administrative department, aged 40 to 60 years (mean age 48.5 +/- 4.5 years) were followed-up for 74 months. Apart from cardiovascular clinical examination with measurement of height, weight, blood pressure and ECG recording, the initial check-up included serum cholesterol, triglycerides and glucose determination and a study of psychological risk factors based on the Bortner's scale for the evaluation of type A profile, and on a questionnaire : the SHEPI for evaluation of the N score (neuroticism). The annual IHD incidence was 9.5% with 4.2% of major events (death or infarction), and 5.3% of minor events (angina pectoris, suggestive ECG changes). Age, tobacco consumption, average systolic blood pressure, serum cholesterol and obesity index were higher in patients who became ill than in those who remained healthy, but overall and separate analysis of major and minor events showed no significant difference apart from age. On the other hand, the study of increased risk according to the level of each of these major factors gave significantly positive results except for the serum glucose level. The correlations between incidence of IDH and the value of each risk factor were not always the same according to the clinical expression (major or minor events). Psychological factors also differed according to the clinical expression of IHD : the Bortner scale was higher in patients developing IHD than in healthy subjects, and higher in those who suffered major events than in those who suffered minor events. On the other hand, the N score was higher in patients with minor events than in those suffering major events. These differences which were not statistically significant in the Marseilles study alone, became significant in the Franco-Belgian cooperative study. The increased risk with the number of associated factors (including psychological) is significant from the association of 2 factors, but only in the fifth decade.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:[Physical and psychological risk factors of ischemic heart diseases. Apropos of a prospective survey in Marseilles]. 642 24

Possible aetiological factors for urinary incontinence were examined in a prevalence study among a random sample of 1000 women aged 18 and over. Infective factors were not markedly associated with incontinence but mechanical factors such as parity and obesity were. No association was found, however, between a history of perineal damage at childbirth and incontinence. Women with incontinence had on average a higher score for a 'neuroticism' trait elicited by questionnaire than women without the disorder.
 ...
PMID:Factors associated with urinary incontinence in women. 706 57

Fifty-nine female and 79 male secondary students rated six stimulus figures (self, ideal self, fat young man/woman, slim young man/woman) on 28 personal rating scales. They also complete the Eysenck personality Inventory. Each of the stimulus-figure data sets was factor analysed and the factor scores were related to role, personality, and perceived weight status by means of correlational and discriminant function analyses. The results showed that the perceives' sex, ethnicity and perceived weight status were related to their perception of the stimulus figures. These relationships included interactions between sex and ethnicity in their effects on reported views of ideal self and fat young woman (FYW). Daughters of European migrants reported more independent and stronger self-aspiration than did their peers, and sons of European migrants saw FYW mor positively that did the other subjects. The observed relationship between females' perceived weight status and their self-concepts suggest that body image may be of greater importance for girls that for boys of this age. Extraversion and neuroticism differed according to sex in their relationships with the subjects' perceptions of the FYW figure. These and other findings indicate that the presence or absence of obesity has relevance for social and psychological processes as well as for medical issues.
 ...
PMID:In the eye of the beholder: social and personal characteristics of teenagers and their impressions of themselves and fat and slim people. 727 50

The author examines the functions of child masturbation in the development of narcissim and distinguishes a demarcation function, a compensation function and a function serving to establish autonomy. In Binswanger's view, certain reactions to child masturbation on the part of parents may affect the interactive relationship between the child and the parent representing the primary object in such a way as to thwart or undermine these functions. The result is the appearance of masturbation substitutes in the form of certain symptoms. Binswanger distinguishes "horrified", "liberal", and "eroticized" reactions by parents, relating the first to compulsion neurosis, the second to obesity, and the third to anorexia/bulimia. The author illustrates his hypotheses with copious references to cases from his own practice.
 ...
PMID:[Childhood masturbation--a genetic viewpoint, especially in anorexia and bulimia nervosa]. 876 92

Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia and obesity in a mixed genetic background. Whereas embryonic fibroblasts lacking PARP exhibit normal DNA excision repair, they grow more slowly in vitro. Here we investigated the putative roles of PARP in cell proliferation, cell death, radiosensitivity, and DNA recombination, as well as chromosomal stability. We show that the proliferation deficiency in vitro and in vivo is most likely caused by a hypersensitive response to environmental stress. Although PARP is specifically cleaved during apoptosis, cells lacking this molecule apoptosed normally in response to treatment with anti-Fas, tumor neurosis factor alpha, gamma-irradiation, and dexamethasone, indicating that PARP is dispensable in apoptosis and that PARP-/- thymocytes are not hypersensitive to ionizing radiation. Furthermore, the capacity of mutant cells to carry out immunoglobulin class switching and V(D)J recombination is normal. Finally, primary PARP mutant fibroblasts and splenocytes exhibited an elevated frequency of spontaneous sister chromatid exchanges and elevated micronuclei formation after treatment with genotoxic agents, establishing an important role for PARP in the maintenance of genomic integrity.
 ...
PMID:PARP is important for genomic stability but dispensable in apoptosis. 930 63


1 2 3 4 5 6 Next >>