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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence of impaired glucose tolerance, the relation of blood glucose levels to the prevalence of risk factors for coronary heart disease (CHD) and to myocardial infarction morbidity and mortality were studied over 15 years among males aged 45-59 years, excluding patients with diabetes mellitus. The data analysis was made in quintils of glucose levels. Impaired glucose tolerance was detected in 20.6% of the males. In the fifth versus the first quintil, there was an increase in the prevalence of systolic and diastolic arterial hypertension (p less than 0.001), obesity (p less than 0.001), low physical activity and hypercholesterolemia (p less than 0.05). As compared with the first, the fifth quintil showed higher total mortality rates and higher myocardial infarction morbidity and cardiovascular disease and CHD morbidity rates. But for age, and major risk factors, the risk for CHD, total and cardiovascular mortality increase at low and high blood glucose concentrations.
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PMID:[Disorders of glucose tolerance and ischemic heart disease]. 177 10

To learn more of the sequelae of obesity in South African elderly rural indigent black women (aged 58-85 years), studies were made on 40 women with BMI greater than or equal to 30, and on 50 non-obese women with BMI of 25 or less, all in outward good health. In the two groups, hypertension (greater than or equal to 160/95 mm Hg) was present in 9 and 5 women (22% and 10%), hypercholesterolaemia (greater than or equal to 5.2 mmol/l) in 28 and 26 women (70% and 52%), hypertriglyceridaemia (greater than or equal to 1.8 mmol/l) in 20 and 16 (50% and 32%), and hyperglycaemia (greater than or equal to 6.7 mmol/l) in 8 and 7 women (20% and 14%). Differences between the obese and non-obese attained significance with blood pressure and serum lipids (P less than 0.01), although not with blood glucose. Both groups were habituated to a low fat high fibre diet. In this context, obesity appeared less evocative of adverse sequelae than prevails in a white population. However, for appropriate validation, longitudinal studies are required.
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PMID:Obesity in indigent elderly rural African women: effects on hypertension, hyperlipidaemia and hyperglycaemia. 179 54

Evidence of old cerebral infarction of magnetic resonance imaging (MRI) is common in acute stroke patients without a prior history of stroke. This experience led us to investigate the incidence of silent cerebral infarction (SCI) in the patients with essential hypertension, as well-known major predisposing factor for stroke. The incidence, number, size and localization of SCI on MRI (MARK-J, 0.1 T) and the prevalence of risk factors for stroke were investigated both in 66 hypertensive patients (WHO stage I or II; 63 +/- 9 (mean +/- S.D.) years old) and in 42 age-matched normotensive patients (61 +/- 9 years old). Risk factors selected were as follows: diabetes mellitus, hypercholesterolemia, daily alcohol intake, cigarette smoking, obesity, cardiac disease (arrhythmia and ischemic heart disease), hyperuricemia and high hematocrit. In hypertensive patients, the relationships between the incidence of SCI and hypertensive damages in major organs were also investigated. SCI was found in 45 out of the 108 subjects studied and a total of 216 SCI lesions were detected. All of the SCI lesions were localized in the subcortical white matter or in the basal ganglia. All SCI lesions were smaller than 3 cm in diameter and 201 lesions (93%) were smaller than 1 cm. The incidence of SCI tended to be higher in hypertensive patients (47%) than that in normotensives (33%) and increased significantly with advancing age in hypertensives from 26.9% in the 50s to 86.7% in the 70s, while no significant increase was noted in normotensives.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Silent cerebral infarction in the patients with essential hypertension]. 179 35

Investigations were undertaken to estimate various energy expenditure during professional work on incidence of hypertension, overweight, obesity, hyperuricaemia and hypercholesterolemia in workers of two enterprises in Upper Silesia. The study was carried out in 1957 individuals (1392 male, 565 female) divided into 5 groups according to the hardness of their work. Serum level of uric acid and cholesterol was determined in all investigated subjects. Incidence of hypertension, overweight and obesity was estimated. It has been stated that incidence of hypertension, hypercholesterolaemia, overweight and obesity in men and hyperuricaemia in both sexes decreased with hardness of the work. The incidence of hypertension, overweight and obesity was not related to hardness of the work in women. The authors conclude that physical activity associated with professional work can be much more in men than in women listed as a preventive measure against arteriosclerosis.
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PMID:[Effect of work load on arteriosclerosis risk factors in employees of 2 Upper Silesia industries]. 179 21

The higher average age of employees, due to the advancement of the compulsory retirement age, and their sedentary lifestyle in automated environments, have become important issues in the workplace, as witnessed in increased incidence of adult disease and decreased physical fitness levels. The purpose of the present study was to evaluate the effects of a long-term corporate fitness program in helping employees to stay well. The fitness program consisted of medical checkups, physical fitness tests, and a physical training program, given on an individual basis. The medical checkups and physical fitness tests were evaluated in 1499 male employees, with the following results. 1) The incidence of obesity showed no significant change. 2) There were no significant changes in total cholesterol levels nor in the incidence of hypertriglyceridemia and hypercholesterolemia. 3) Physical fitness was markedly improved. 4) There was a decrease in the percentage of smokers. These results suggest that a long-term corporate fitness program is effective for improving the health and fitness levels of employees and for preventing the progression of adult disease.
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PMID:Effects of long-term corporate fitness program on employees' health. 182 Apr 40

Coronary risk factors were determined in a prospective study of 1,414 elderly persons (999 women and 415 men), mean age 82 +/- 8 years. Of 1,414 persons, 215 (15%) were black and 1,140 (81%) were white. The prevalences of cigarette smoking, hypercholesterolemia, low serum high-density lipoprotein cholesterol, and increased serum total cholesterol/high-density lipoprotein cholesterol ratio were not significantly different in elderly blacks and whites. Elderly blacks had a higher prevalence of hypertension (50% versus 36%, P less than 0.001), diabetes mellitus (27% versus 19%, P less than 0.01), and obesity (11% versus 5%, P less than 0.005) and a lower prevalence of hypertriglyceridemia (9% versus 15%, P less than 0.05) than elderly whites. In elderly persons with hypertension, electrocardiographic left ventricular hypertrophy occurred in 19% of blacks and 14% of whites (P not significant), echocardiographic left ventricular hypertrophy occurred in 72% of blacks and 56% of whites (P less than 0.01), and concentric left ventricular hypertrophy occurred in 60% of blacks and 39% of whites (P less than 0.001).
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PMID:Prevalence of coronary risk factors in elderly blacks and whites. 182 74

The paper presents the dynamics of risk factors which was traced during prophylactic medical examinations and its relation to death rates among 40-59-year-old males from Frunze over 5 years. Prophylactic measures were found to lead to a positive dynamics of risk factors such as smoking, low physical activity, hypercholesterolemia, arterial hypertension in groups of active prevention. There was a decrease in death rates due to cardiovascular diseases, including myocardial infarction, stroke, among individuals with arterial hypertension, obesity, and low activity in the same group.
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PMID:[Relation between coronary disease risk factors and mortality among men aged 40-59 years in the city of Frunze (5-year follow-up)]. 183 17

Atherosclerotic changes of carotid and lower extremity arteries were studied in the selected industrial population represented by 58 men with arterial hypertension. Affection of peripheral arterial system was detected by means of non-invasive ultrasound methods. Stenoses of carotid arteries were recorded in 19% of cases (11 of 58), stenoses of lower extremity arteries in 7% (4 of 58). Hypertonic individuals did not show neurological symptomatology, including one patients with total occlusion of the arteria carotis interna. One man underwent the attack of cerebrovascular ischemia. Stenoses of lower extremity arteries were also in the subclinical stage and without intermittent claudications. A high number of risk factors of atherosclerosis was found in the series: obesity in 90%, smoking 57%, hypercholesterolemia in 47%. Peripheral arterial changes were associated with combined risk factors (two and more). This indicates their involvement in the origin and development of atherosclerotic lesions.
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PMID:Carotid and lower extremity arterial disease in hypertensions. 183 75

Sexual impotence is the main andrological complication of diabetes mellitus and is the consequence of nervous, vascular and psychological factors which act either separately or in association. An attempt to prevent this complication will be successful if performed early before impotence has became irreversible. Neuropathy-induced impotence can be prevented by obtaining a good metabolic control of diabetes and/or by using some specific drugs such as gangliosides and aldose reductase inhibitors. The vascular causes of erectile failure can be prevented by reducing or removing associated risk factors such as smoking, hypertension, obesity, hypercholesterolemia, sedentariness and insulin-resistance. Finally, correct information and reassurance of the patient and his partner can prevent the negative role played by psychological factors on the sexual dysfunctions complained by the diabetic subject.
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PMID:[Is it possible to prevent andrological complications in the diabetic patient?]. 183 28

Isolated vascular risk factors (e.g. hypercholesterolemia, hypertension, etc) are not commonly found in high risk patients. In fact, more often, constellations of risk factors are detected, giving rise to a so-called polymetabolic syndrome. Among the associated factors, insulin-resistance with altered carbohydrate tolerance, hypertriglyceridemia, hypertension and reduced HDL-cholesterol levels are most often described. Recent epidemiological studies underline the possible genetic basis of this syndrome, as shown in the highly consanguineous Utah population. The major determinant of the syndrome seems to be insulin-resistance. Development of hypertension within this syndrome may be linked to hyperinsulinemia, with increased intracellular Ca++ and/or obesity. The reduction of HDL-cholesterol may be secondary to the hypertriglyceridemia, again secondary to hyperstimulation, most likely from hyperinsulinemia. In the polymetabolic syndrome frequent alterations in the hemocoagulative system, mainly hyperfibrinogenemia/reduction of fibrinolysis, are recognized. Recently a circulating antagonist of fibrinolysis, PAI-1 has been described: PAI-1 levels are significantly correlated to those of plasma triglycerides. Regulation of fibrinogenemia is, instead, more complex and may only be partly linked to an increase of circulating lipids/lipoproteins. Development and stabilization of the syndrome, with the consequent vascular alterations, may be effectively prevented or treated by diet, and also by specific drugs. The choice is addressed to drugs reducing insulin-resistance and/or plasma triglycerides, possibly also raising HDL-cholesterol and reducing fibrinogen; among the possible options, bezafibrate seems to exert the largest number of effects.
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PMID:[The physiopathology and pharmacological approach to multiple metabolic and blood coagulation syndromes, the characteristics of atherogenesis]. 184 8


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