Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Edible fats are important food components that enhance palatability by providing texture and enhancing flavour. They also provide essential fatty acids and fat soluble vitamins. In addition, we enjoy eating foods containing fat, but there is also a negative side; excessive consumption may not be good for health, but we still have doubts to answer the question, What are the right amounts and types of fat we should use and eat?. The consumer is now aware of the relationship between dietary fat and health, but there is a great deal of confusion. One of the well-known problems of the increase in fat intake is the higher prevalence of overweight and obesity in all the industrialized countries, for the adults but specially for the children. Several questions arise... What are the health implications of this phenomenon? The health implications include usually a combination of increased risk of cardiovascular diseases, type 2 diabetes, some cancers, arthritis, gallstones, and mental problems. The health implications for the nations could see the start of a decline in longevity. What are the causes of the recent rise in obesity? Individual's energy balance changes due to less energy expanded compounded by more being consumed. What can be done about it? There are three main components driving obesity: First and second, the ubiquitous availability of high energy food as well as a decline in everyday activity. The third is a controlling factor in that humans evolved in an environment prone to food shortages. In fact, our natural drivers are geared to consuming more than we need. Our natural checks serve to answer to hunger and much less to excess. Consequently the ready availability of energy dense foods and decline in metabolic activity both serve to drive obesity. A recent report from WHO (2003) point that the increase in the quantity and quality of the fats consumed in the diet is an important feature reflected in the national diets of countries. An important point is that there has been a remarkable increase in the intake of dietary fats over the past three decades and that this increase has taken place everywhere except in Africa. In fact, the increase in dietary fat supply worldwide exceeds the increase in dietary protein supply. The average global supply of fat has increased by 20 g per capita since 1960's, more pronounced in the Americas, East Asia, and the European Community. An important issue not enough considered is related to the contribution of expanding portion sizes to the obesity epidemic. Many observations hint that portions sizes are increasing. We should remember that larger portions not only contain more energy but also encourage people to eat more, which makes more difficult to balance static levels of physical activity. Marketplace food portions have increases in size universally and exceed the recommended standard ones. Educational and other public health efforts to address obesity should focus on the need for people to consume smaller portions. Another questions that should be discussed but difficult to answer are: What role can the food industry, marketing and advertising play? And schooling? And to what extent can and should the Governments influence lifestyle choices? "Knowing is not enough; we must apply. Willing is not enough; we must do" Goethe.
 ...
PMID:Controlling obesity: what should be changed? 1724 93

The disorder now known as metabolic syndrome has been recognized for 50 years, but its multiple definitions have led to some confusion and even doubt about its very nature. Metabolic syndrome is directly linked to the presence of android obesity, which indicates insulin resistance and lies at the root of all risk factors and early indications of type 2 diabetes. It is diagnosed by systematic measurements of waist size and its direct interpretation taking ethnic origin into account. This pragmatic approach avoids the uncertainties generated by differing definitions and is subtler than the presence or absence of metabolic syndrome in a given patient. Drug-free treatment of an android obese patient is inexpensive and effective, but this apparently simple approach masks difficulties of application. However, these are sociological problems.
 ...
PMID:Should we have more definitions of metabolic syndrome or simply take waist measurement? 1761 Nov 37

The metabolic syndrome is a heterogeneous complex that is clinically interpreted as an indicator of an increased risk of diabetes mellitus, cardiovascular morbidity and mortality. The diagnosis of metabolic syndrome is made, if at least three out of five factors - dysglycemia, visceral obesity, increased triglycerides, decreased HDL cholesterol, arterial hypertension - are present. Both the popularity and criticism of the metabolic syndrome have increased over recent years. One crucial problem are the currently existing definitions. This is illustrated on the basis of recent primary-care data from Germany, showing a prevalence ranging from 19% to 31% depending on the definition used. The debate about the rationale of the concept in terms of risk prediction for cardiovascular diseases points at one weakness of the concept. The entire discussion is mainly influenced by different approaches: a simple pedagogic approach, a pathophysiological approach, with insulin resistance as main focus of research, and a clinical-epidemiologic approach, where a cluster of different risk factors for cardiovascular disease risk prediction forms the initial scientific interests. Acknowledging these different perspectives might help reduce the confusion associated with the meaning and usefulness of the metabolic syndrome.
 ...
PMID:[The metabolic syndrome -- a controversial diagnostic concept]. 1797 26

Patella malalignment is a recognized cause of knee pain, tilt being one of its more common forms. Although patellar tilt has been described both on the physical examination and on computerized imaging, to date the correlation between the two has not been established. A strong correlation would strengthen the value of each. Moreover, in situations where tilt cannot be clinically assessed (e.g. obesity), CT or MR imaging could be an adequate substitute for the clinical determination of tilt. We propose to correlate the physical examination with the magnetic resonance examination by way of an MR Tilt Angle. This angle is measured in a manner similar to the assessment of tilt on the physical examination, in that a line is drawn across the medial and lateral borders of the patella and referenced off the posterior femoral condyles. Most tilt angles use the slope of the lateral facet as a measure of tilt. These tilt angles paradoxically diminish as patellar tilt increases, a potential source of confusion. In this study, we use an MRI tilt angle that increases in the same direction as the actual tilt, which is more intuitive. We examined 30 patients with tilt and 51 patients without tilt. Patients with significant tilt on the physical examination can be expected to have an MRI Tilt Angle that is 10 degrees or greater whereas an angle of less than 10 degrees is associated with the absence of significant tilt on the physical examination. This MRI Tilt Angle fills the need for an easy, objective, intuitive measure of tilt and is an excellent adjunct to the physical examination.
 ...
PMID:Patellar tilt: the physical examination correlates with MR imaging. 1802 86

Shoulder dystocia is a birth emergency that occurs in approximately 1% of all births. Shoulder dystocia can be followed by broken clavicle or humerus, brachial plexus injury, fetal hypoxia, or death. Although risk factors for shoulder dystocia include previous birth complicated by shoulder dystocia, maternal obesity, excessive prenatal weight gain, fetal macrosomia, gestational diabetes, and instrumental delivery, shoulder dystocia is not predictable. Perinatal nurses can reduce the risk for shoulder dystocia by teaching mothers about optimal weight gain in pregnancy and assisting mothers with diabetes to prevent hyperglycemia through diet management and medication use. During childbirth preparation or early labor, nurses can educate mothers about position changes and maneuvers used for shoulder dystocia. Nurses play a vital role in obtaining assistance during a shoulder dystocia, keeping time, assisting with maneuvers such as suprapubic pressure, and documenting the dystocia management. Nurses can assist mothers and families to review the shoulder dystocia and any newborn injuries in the postpartum period, thereby reducing confusion and anxiety. Regular drills and case reviews help build nursing shoulder dystocia management skills.
 ...
PMID:Shoulder dystocia: nursing prevention and posttrauma care. 1828 97

There is currently substantial confusion between the conceptual definition of the metabolic syndrome and the clinical screening parameters and cut-off values proposed by various organizations (NCEP-ATP III, IDF, WHO, etc) to identify individuals with the metabolic syndrome. Although it is clear that in vivo insulin resistance is a key abnormality associated with an atherogenic, prothrombotic, and inflammatory profile which has been named by some the "metabolic syndrome" or by others "syndrome X" or "insulin resistance syndrome", it is more and more recognized that the most prevalent form of this constellation of metabolic abnormalities linked to insulin resistance is found in patients with abdominal obesity, especially with an excess of intra-abdominal or visceral adipose tissue. We have previously proposed that visceral obesity may represent a clinical intermediate phenotype reflecting the relative inability of subcutaneous adipose tissue to act as a protective metabolic sink for the clearance and storage of the extra energy derived from dietary triglycerides, leading to ectopic fat deposition in visceral adipose depots, skeletal muscle, liver, heart, etc. Thus, visceral obesity may partly be a marker of a dysmetabolic state and partly a cause of the metabolic syndrome. Although waist circumference is a better marker of abdominal fat accumulation than the body mass index, an elevated waistline alone is not sufficient to diagnose visceral obesity and we have proposed that an elevated fasting triglyceride concentration could represent, when waist circumference is increased, a simple clinical marker of excess visceral/ectopic fat. Finally, a clinical diagnosis of visceral obesity, insulin resistance, or of the metabolic syndrome is not sufficient to assess global risk of cardiovascular disease. To achieve this goal, physicians should first pay attention to the classical risk factors while also considering the additional risk resulting from the presence of abdominal obesity and the metabolic syndrome, such global risk being defined as cardiometabolic risk.
 ...
PMID:Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. 1835 55

Wernicke's encephalopathy (WE) is one of the potential complications of obesity surgery. It is an acute neuropsychiatric syndrome resulting from thiamine deficiency often associated with repeated vomiting. The classic triad is frequently reported in these patients (optic neuropathy, ataxia and confusion), associated with uncommon features. Cerebral impairment affects the dorsal medial nucleus of the thalamus and the periaqueductal grey area, appearing on MRI, as hyperintense signals on T2, Flair and Diffusion weighted imaging. Early diagnosis and parenteral thiamine are required to decrease morbidity and mortality. We report a case of WE and Korsakoff's syndrome in a young obese patient after subtotal gastrectomy, who still has substantial sequelae. The contribution of MRI with diffusion-weighted imaging is illustrated. The interest of nutritional supervision in the first weeks and preventive thiamine supplementation in case of repeated vomiting are of particular importance in these risky situations.
 ...
PMID:[Wernicke encephalopathy after subtotal gastrectomy for morbid obesity]. 1855 79

Pulmonary embolism (PE) is a cause of death after total hip and knee arthroplasty (THA, TKA). We characterised the patient population suffering from in-hospital PE and identified perioperative risk factors associated with PE using nationally representative data. Data from the National Hospital Discharge Survey between 1990 and 2004 on patients who underwent primary or revision THA/TKA in the United States were analysed. Multivariate regression analysis was performed to determine if perioperative factors were associated with increased risk of in-hospital PE. An estimated 6,901,324 procedures were identified. The incidence of in-hospital PE was 0.36%. Factors associated with an increased risk for the diagnosis of PE included: revision THA, female gender, dementia, obesity, renal and cerebrovascular disease. An increased association with PE was found among patients with diagnosis of Adult Respiratory Distress Syndrome (ARDS), psychosis (confusion), and peripheral thrombotic events. Our findings may be useful in stratifying the individual patient's risk of PE after surgery.
 ...
PMID:Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study. 1892 95

The metabolic syndrome is a constellation of interrelated metabolic risk factors that appear to directly promote the development of diabetes and cardiovascular disease. However, in 2005, the American Diabetes Association and the European Association for the Study of Diabetes jointly stated that no existing definition of the metabolic syndrome meets the criteria of a syndrome, and there have been endless debates on the pros and cons of using the concept of this syndrome. The controversy may stem from confusion between the syndrome and obesity. Obesity is an epidemic, essentially contagious disease caused by an environment of excess nutritional energy and reinforced by deeply rooted social norms. The epidemic of obesity should be prevented or controlled by social and political means, similar to the approaches now being taken to combat global warming. The diagnosis of metabolic syndrome is useless for this public purpose. The purpose of establishing criteria for diagnosing metabolic syndrome is to find individuals who are at increased risk of diabetes and cardiovascular disease and who require specific therapy including diet and exercise. The syndrome may be an adipose tissue disease different from obesity; in that case, it would be characterized by inflammation clinically detected through systemic inflammatory markers such as high-sensitivity C-reactive protein and insulin resistance reflecting histological changes in adipose tissue. However, many problems in defining the optimal diagnostic criteria remain unresolved.
 ...
PMID:The metabolic syndrome as a concept of adipose tissue disease. 1895 97

Acute pancreatitis is a dynamic, often progressive disease; 14-20% require intensive care in its severe form due to multiorgan dysfunction and/or failure. This review was created using systematic literature review of articles published on this subject in the last 5 years. The outcome of severe acute pancreatitis is determined by the inflammatory response and multiorgan dysfunction - the prognostic scores (Acute Physiology and Chronic Health Evaluation, Glasgow Prognostic Index, Sepsis-related Organ Failure Assessment, Multi Organ Dysfunction Syndrome Scale, Ranson Scale) can be used to determine outcome. Clinical signs (age, coexisting diseases, confusion, obesity) and biochemistry values (serum amylase, lipase, C-reactive protein, procalcitonin, creatinine, urea, calcium) have important prognostic roles as well. Early organ failure increases the risk of late abdominal complications and mortality. Intensive care can provide appropriate multi-function patient monitoring which helps in early recognition of complications and appropriate target-controlled treatment. Treatment of severe acute pancreatitis aims at reducing systemic inflammatory response and multiorgan dysfunction and, on the other side, at increasing the anti-inflammatory response. Oral starvation for 24-48 hours is effective in reducing the exocrine activity of the pancreas; the efficacy of protease inhibitors is questionable. Early intravascular volume resuscitation and stable haemodynamics improve microcirculation. Early oxygen therapy and mechanical ventilation provide adequate oxygenation. Electrolyte and acid-base control can be as important as tight glucose control. Adequate pain relief can be achieved by thoracic epidural catheterization. Early enteral nutrition with immunonutrition should be used. There is evidence that affecting the coagulation cascade by activated protein C can play a role in reducing the inflammatory response. The complex therapy of acute pancreatitis includes appropriate antibiotics, thrombo-embolic prophylaxis and in certain cases plasmapheresis and/or haemofiltration. Reducing intraabdominal pressure may be necessary in the acute phase. Intensive care multidisciplinary teamwork can reduce the mortality of severe acute pancreatitis from 30% to 10%.
 ...
PMID:[Principles of intensive care in severe acute pancreatitis in 2008]. 1900 43


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>