Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Researchers analyzed 1968-1974 data of 154 women attending 1 of 17 large family planning clinics in England and Scotland and referred to a hospital for treatment of carpal tunnel syndrome (CTS) to determine CTS characteristics. The women were part of the large Oxford-Family Planning Association cohort study. A strong association between age and CTS existed, but the crude hospital referral trend (p.001) declined somewhat when considering confounding variables, e.g., smoking, (adjusted rate p.01). Cigarette smoking had a significant effect regardless of the age group (20-44 year old, p.001; 45 years plus, adjusted p.05). The researchers reported that additional research is needed to explain the mechanism involved in smoking and CTS since a mechanism is not apparent. The results showed that the longer the interval since last use of oral contraceptives (OCs) the higher the chance of acquiring CTS, but this was less significant than smoking (20-44 year old, p..01; 45 years plus, adjusted p.05). The data indicated a strong positive relationship between Quetelet's obesity index and 1st referral for CTS (20-44 year old, p..01; 45 years plus, p..05). Other significant relationships, albeit less significant than between obesity and referral, included body weight (positive) and height (negative). A negative association occurred between varicose veins and CTS. The most significant positive association between an existing disease and CTS was menstrual disorders (p=.001). Additional similar associations existed for orthopedic conditions and gastrointestinal tract symptoms. The relationships between CTS and OC use, menstrual disorders, and obesity may be related to pressure on the median nerve due to fat or edema near the carpal tunnel.
 ...
PMID:Epidemiology of carpal tunnel syndrome in women of childbearing age. Findings in a large cohort study. 226 60

Possible connections between carpal tunnel syndrome (CTS) and exposure to vibrating handheld tools, repetitive wrist movements, and heavy manual work were examined in a case-referent study. The cases were 38 men operated on for CTS between 1974 and 1980. For each case, two referents were drawn from among other surgical cases (hospital referents) and two further referents from the population register and telephone directory, respectively (population referents). Thirty four of 38 cases (89%) and 143 of 152 referents (94%) were interviewed by telephone. An increased prevalence of obesity, rheumatoid disease, diabetes, or thyroid disease was observed among the cases but most did not suffer from any of these disorders. CTS was significantly correlated with exposure to vibration from handheld tools and to repetitive wrist movements but showed a weaker correlation with work producing a heavy load on the wrist. A cause-effect relation between CTS and exposures to handheld vibrating tools and to work causing repetitive movements of the wrist seems probable. Some differences between hospital and population referents indicate that a case-referent study of this type could be biased by inappropriate selection of referents.
 ...
PMID:Carpal tunnel syndrome (CTS) and exposure to vibration, repetitive wrist movements, and heavy manual work: a case-referent study. 292 Jan 42

Increased weight and, more recently, body mass index (BMI), have been suggested as risk factors for carpal tunnel syndrome (CTS). In an effort to determine the relative risk (RR) of obesity in the development of CTS, 949 patients who had an evaluation of the right upper extremity that included motor and sensory conduction studies of the median and ulnar nerves were reviewed. Of these patients, 261 were diagnosed with a median mononeuropathy at the wrist. Those individuals who were classified as obese (BMI > 29) were 2.5 times more likely than slender individuals (BMI < 20) to be diagnosed with CTS. Forty-three percent of obese women and 32% of obese men had the diagnosis of CTS compared to 21% of slender women and 0% of slender men.
 ...
PMID:The relationship between body mass index and the diagnosis of carpal tunnel syndrome. 796 59

Normal human ageing is associated with changes in body composition which include a decrease in muscle mass and strength, bone mass loss and increase in adipose mass. A physiological decrease in growth hormone (GH) and IGF-I secretion accompanies these changes. Many of the physiological changes that accompany normal human ageing are very similar to those found in GH deficient patients. Nevertheless, responsiveness to exogenous administered GH persists with advancing age. GH administration to elderly individuals has produced an decrease in fat mass and an increase in lean body mass, being this finding consistent with the hypothesis that GH deficiency could be a contributing cause to senescent changes in some elderly individuals. GH treatment has also been used with encouraging results in adult subjects with isolated or combined GH deficiency. On the other hand, several clinical studies have recently shown the efficiently of GH treatment on diverse pathological processes such as severe catabolic states (surgery, sepsis, trauma, buns), osteoporosis, diabetic ulcers and obesity. The most frequent side effects are sodium and water retention, impairment in glucose tolerance and carpal tunnel syndrome, although in general the treatment has been well tolerated. The clear definition of the therapeutical applications of GH in the adult warrants further clinical investigation.
 ...
PMID:[New physiological and pharmacological aspects of the growth hormone (II). Therapeutic applications in adults]. 849 41

Pain, numbness, and tingling through the median nerve distribution, known as carpal tunnel syndrome (CTS), has been associated with many personal risk factors. Previous studies have implicated obesity as a risk factor for median neuropathy at the carpal tunnel. A case-control design was undertaken to explore the association between obesity and CTS. Six hundred patients presented with symptoms of upper-extremity disorders for independent medical examination related to a disability or compensation claim. The 300 patients with electrodiagnostic evidence of CTS were compared with 300 control subjects from the same initial population. All patients were categorized according to their body mass index. The analysis was stratified for the possible confounding factors of cervical spine abnormalities, Martin-Gruber interconnections, age, and sex. A statistically significant association was found between obesity and median neuropathy. The implications of such a relationship are discussed in light of the contemporary debate over the etiology of cumulative trauma disorders.
 ...
PMID:A case-control study of obesity as a risk factor for carpal tunnel syndrome in a population of 600 patients presenting for independent medical examination. 919 16

The reported incidence of work-related carpal tunnel syndrome has skyrocketed; however, many cases have an underlying systemic cause. A methodical investigation--including appropriate imaging studies and laboratory testing--can differentiate symptoms that are primarily occupational from those with associated medical illness or obesity.
 ...
PMID:Carpal tunnel syndrome: is it work-related? 1008 26

Risk factors for the development of carpal tunnel syndrome in women were studied by means of a nested case-control analysis of a prospective cohort study of the health effects of oral contraception in British women. A total of 1,264 women who had a diagnosis of carpal tunnel syndrome reported by their general practitioner between 1968 and 1993 were compared with 1,264 age-matched control women who did not have this diagnosis. The syndrome was associated in older women with some hormonal factors, notably past use of oral contraception (adjusted odds ratio in women aged 40 years and over = 1.38, 95 percent confidence interval: 1.08, 1.76) and more generally with obesity (adjusted odds ratio = 1.68, 95 percent confidence interval: 1.29, 2.18). However, the strongest link was with a previous history of another musculoskeletal complaint for which consultation had been sought (adjusted odds ratio = 1.98, 95 percent confidence interval: 1.61, 2.42). Previous findings of a higher risk in women with diabetes and myxoedema were confirmed, but these contribute only a small proportion of all cases in women. There was no link with psychologic problems or nonmusculoskeletal pain complaints. The previously described increased incidence of carpal tunnel syndrome in women may be partly due to hormonal factors, but is also related to an underlying propensity to musculoskeletal problems and their higher overall frequency in women.
 ...
PMID:Carpal tunnel syndrome: a nested case-control study of risk factors in women. 1073 38

This article summarizes the results of a large-scale population-based study conducted to determine the prevalence of carpal tunnel syndrome in the Swedish general population. The study utilized a health questionnaires as well as clinical and electrophysiological examinations. Population prevalence rates of carpal tunnel syndrome, based on clinical diagnosis and electrophysiological criteria, were calculated. Obesity and specific work-related hand activities were shown to be risk factors for carpal tunnel syndrome.
 ...
PMID:[Prevalence for clinically proved carpal tunnel syndrome is 4 percent]. 1110 59

Growth hormone (GH) secretion declines progressively with aging, and many age-related changes resemble those of the adult GH deficiency (GHD) syndrome, including a decrease in lean body mass; an increase in body fat, especially in the visceral/abdominal compartment; adverse changes in lipoproteins; and a reduction in aerobic capacity. The increase in central obesity can further inhibit GH secretion. GH replacement is effective in reversing many of these changes in adult GHD, and GH is now FDA approved for treatment of adults with documented GHD or hypopituitarism, although there is still only limited experience with its long-term benefits, side effects, and risks. This early experience with GHD has led to speculation that replacing GH or stimulating its secretion may also be beneficial in normal aging, and to widespread off-label use of GH in this context; however, there are still very few well controlled studies of the effects and side effects of GH or GH secretagogues in aging. All published studies are of 6 months or shorter treatment periods. From this limited experience there is a consensus that GH has effects on body composition, but reports disagree on effects on psychological or physical functional performance. Older adults are much more susceptible to the dose-related side effects of GH, including peripheral edema, carpal tunnel syndrome, and a variable decrease in insulin sensitivity; and it is not known whether chronic GH treatment affects the risk of malignancy or has other long-term risks. Thus while short-term results are somewhat encouraging, the evidence on risks and clinically pertinent benefits is still lacking to support the use of GH in normal aging outside of clinical studies. In evaluating patients with clinical features suggesting GHD, which can be quite nonspecific, it is important to assess the presence or absence of true GH deficiency by the context (pituitary disease or its treatment, childhood GHD) and by appropriate GH stimulation tests before considering GH replacement.
 ...
PMID:Age-related changes in growth hormone secretion: should the somatopause be treated? 1085 71

One hundred and eighty five consecutive patients with carpal tunnel syndrome (CTS) seen at Jordan University Hospital (JUH) over an 18-month-period were studied retrospectively. Mean age=45 years (range 19-80); 156 females, 29 males. The most common predisposing factors were stressful manual work, followed by diabetes mellitus and obesity (body mass index, BMI>29). The most frequent symptoms were nocturnal hand paresthesiae. The respective sensitivities of Tinel and Phalen signs were 61 and 46%. The diagnostic yield of nerve conduction studies (NCS) was 80% and the most sensitive NCS technique was the median palm-to-wrist (PW) technique with a yield of 61%. Seventy percent of the hands with electrophysiological CTS were moderate and severe. One hundred and forty patients received conservative treatment and 45 underwent surgical decompression.
 ...
PMID:Carpal tunnel syndrome: a series observed at Jordan University Hospital (JUH), June 1999-December 2000. 1179 77


1 2 3 4 Next >>