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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 27-year old woman was admitted to our hospital because of oligomenorrhea, hirsutism and obesity. Her menstrual period has been irregular since she was 14 years old. Her weight increased rapidly after the age of 15 and she became obese. Hirsutism was noticed at the age of 16. The diagnosis of polycystic ovary syndrome was made on her illness through the endocrinological examinations: (1) The response of LH to LH-RH administration was much higher than that of FSH. (2) The concentration of plasma testosterone was increased. (3) Plasma level of E2 was decreased while that of E1 was increased. (4) CT scan showed bilateral ovarian cyctic masses. In addition, hyperinsulinemia was observed during the 75g glucose tolerance test and the presence of insulin resistance was suggested. As she was overweight (BMI; 33.6 kg/m2), weight loss was expected to improve her hormonal abnormalities. She went on a very low calorie diet of 420 kcal/day (Optifast, Sandoz, USA). When she lost around 9kg of weight, her menstruation period started that has not been observed for the previous 5 months. Plasma levels of LH, FSH and testosterone were lowered following the weight loss. The responses of LH to LH-RH and IRI to glucose were decreased as well. She left the hospital after the second menstruation occurred at the proper period. From these results, the importance of weight loss was suggested in overweight patients with polycystic ovary syndrome. The benefit of very low calorie diet was also noticed since it brought a rapid weight loss as well as rapid improvements of hormonal abnormalities.
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PMID:[Hormonal abnormalities were improved by weight loss using very low calorie diet in a patient with polycystic ovary syndrome]. 795 30

Endometrial carcinoma is the most frequent malignancy of the female reproductive tract, and irregular vaginal bleeding is its most common symptom. It is most common among postmenopausal women and is associated with obesity, nulliparity, and anovulation. Oral contraceptive (OC) use and tobacco smoking have been reported to protect against it. A 30-year-old nulligravida nulliparous woman presented with menometrorrhagia. She had had normal menses since age 11, she had smoked a pack of cigarettes a day for 15 years, and had been obese since age 15 (weighing 302 pounds). At age 26, she started taking a combination OC containing .1 mg ethynodiol diacetate and 35 mcg ethynyl estradiol (EE). 4 years later she gradually developed menorrhagia which improved upon changing the OC to .3 mg norgestrel and 30 mcg EE. Subsequently she developed early cycle metrorrhagia and was placed on .5 mg norgestrel and 50 mcg EE. She continued having early and midcycle breakthrough bleeding with clots. Physical examination and test results including a PAP smear were normal. She was taken to the emergency department because of continued bleeding. The uterus sounded to 14 cm. Curettings were consistent with grade 1-2, well-differentiated adenocarcinoma of the endometrium. 3 weeks later, she had total abdominal hysterectomy, bilateral salpingo-oophorectomy, and peritoneal biopsy for cytological examination. The pelvis and the abdomen were free of metastasis. Histological examination revealed a superficially invasive, well-differentiated adenocarcinoma consistent with stage IB, grade 1%. Ploidy analysis uncovered 12.5% tetraploid, with 0% aneuploid or hyperploid cells with 8.5% of the cells in S phase and 21% in the proliferative phase. Both estrogen and progesterone receptors were positive. The ploidy analysis and receptor status were consistent with the low-grade nature of the lesions. Postoperative radiation was not recommended, and the patient was well 6 months postoperatively.
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PMID:Menometrorrhagia in an oral contraceptive user. 842 44

In August 1985 Sharon Russell was dismissed from Salve Regina College just before her senior year of nursing education. The reasons given for her dismissal focused on Russell's obesity and her inability to lose weight. The issues raised by this case pose important questions that nursing programs and nurse educators must address. This article explores the questions raised by Russell: (1) What constitutes substantial compliance with both academic and nonacademic performance criteria in a contract between a student and an educational institution? (2) What duties to preserve the privacy interests of students may be imposed on programs and educators? Ms Russell's case has been settled. She established that she had met the terms of the contract and substantially complied with the academic and nonacademic criteria of the nursing curriculum. She was awarded monetary damages for the college's breach of contract in nonperformance of an agreement to educate. She did not prevail in her claims of intentional infliction of emotional distress or invasion of privacy. She did, however, put nursing education programs on notice that colleges and universities are not immune from these contractual challenges and must demonstrate respect and consideration for student's personal concerns.
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PMID:Responsibilities of nursing education: the lessons of Russell v Salve Regina. 851 47

A 43-year-old female was admitted to our hospital for polydipsia and hyperglycemia. She had total blindness and globes were not recognized by inspection, indicating clinical anophthalmia. Physical examination revealed short stature, obesity, prematurely gray hair, shortness of fingers and toes, syndactyly, and multiple dental caries. Laboratory examination showed hyperglycemia, increased glycosilated hemoglobin (HbA1c) and insulin resistance on euglycemic glucose clamp. Blunted growth hormone (GH) secretion was shown in response to insulin-induced hypoglycemia, arginine infusion, and GH-releasing hormone (GHRH) loading test, and in 24 h spontaneous GH profile. Magnetic resonance imaging (MRI) and computed tomography (CT) showed dysostosis of orbit, defect of optic nerve, enlarged suprasellar cistern, and prolonged pituitary stalk. This may be the first report of a unique case with GH deficiency accompanied by clinical anophthalmia, hypoplastic orbits, digital dysplasia, short stature, obesity, and diabetes mellitus.
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PMID:Unique case of growth hormone (GH) deficiency accompanied by clinical anophthalmia, hypoplastic orbits, digital dysplasia, short stature, obesity, and diabetes mellitus. 872 46

A 28-year-old woman who complained of irregular menstruation was diagnosed as suffering from trisomy 18 mosaicism. She was karyotyped because of her characteristic face, mild mental retardation and aberrant hyperpigmentation of the skin. Her motor function was within normal range. Physical and laboratory examinations, however, revealed obesity, short stature, minor anomalies of the fingers, many areas of hyperpigmentation on the trunk and the hips, hypergonadotropinemia, diabetes mellitus, liver dysfunction, and hyperlipidemia. The ratios of normal/trisomy 18 were 4:135 in blood lymphocytes, 3:11 in a hyperpigmented area of the skin, 20:0 in a normally pigmented area of the skin, and 14:6 in ascitic cells. Laparoscopy revealed that her ovaries contained neither follicles nor germ cells.
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PMID:Trisomy 18 mosaicism associated with secondary amenorrhea: ratios of mosaicism in different samples and complications. 874 Sep 20

A 76-year-old diabetic woman with non-obese Cushing's syndrome developed poor glycemic control with glibenclamide. She presented with a slight weight loss while bedridden due to a fall. Cushing's syndrome in this patient was suspected because of hypercortisolemia with eosinopenia, and adrenal Cushing's syndrome was diagnosed by endocrine and radiological examinations. A right adrenal adenoma was confirmed by autopsy. In this patient, progressive obesity and other common features of Cushing's syndrome may have been concealed by aging itself and coexisting diabetes mellitus.
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PMID:Non-obese Cushing's syndrome in an aged woman with non-insulin-dependent diabetes mellitus. 877 70

A female infant is described with hypoglycaemia, hypotonia, obesity of the trunk and thighs, and mild dysmorphic features. Growth parameters were consistently above the 90th centile. Chromosome analysis showed her to have a derived chromosome 9 inherited from a maternal t(3;9)(p25;p23) by adjacent I segregation. She had features in common with both the dup(3p) and del(9p) syndromes. There are few reports of this chromosome rearrangement and the features are milder than expected for the degree of imbalance, complicated in males by sex reversal. The repeated reports of macrosomia may suggest an overgrowth syndrome.
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PMID:A mild phenotype associated with der(9)t(3;9) (p25;p23). 881 57

We report on a 15-year-old girl with mental retardation, obesity, short stature and minor anomalies. She had 47 chromosomes with a minute extra ring which was identified by FISH to be derived from chromosome 17.
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PMID:Identification of a supernumerary marker derived from chromosome 17 using FISH. 884 6

We reviewed the charts of 36 women who had laparoscopic-assisted vaginal hysterectomies (LAVH) at Belfast City Hospital over a 3 year period. The average operating time was 105 minutes. However, patients had a shorter duration of hospitalization (< 4 days for 96% of patients) with rapid recuperation (3.4 weeks). Complications occurred in 7 patients. One patient developed a vesico-vaginal fistula which was diagnosed post operatively and successfully repaired 5 months later. Technical difficulty was reported in one patient because of significant adhesions and poor access due to obesity. She went on to develop a pelvic abscess which was drained. Patient satisfaction with the operation was high. LAVH is an effective operation in selected cases and in experienced hands the complication rate is low. In the future it may become a valid alternative to open abdominal hysterectomy.
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PMID:Laparoscopic-assisted vaginal hysterectomy: initial experience. 897 84

We report a case of a patient who developed type II diabetes after receiving a successful combined kidney and pancreas transplant for type I diabetes and end-stage renal disease. This patient underwent a combined kidney and pancreas transplant and had no evidence of rejection with good function following the transplant for nine months. The patient developed significant post-transplant obesity with her transplant weight of 80 kg rising to 109 kg. At this level of obesity, the patient developed fasting hyperglycemia of 180 mg/dl with no change in her renal function or her pancreas exocrine function. She developed hyperinsulinemia to this fasting hyperglycemia. The clinical course of this patient demonstrates that rapid weight gain following transplantation can result in type II diabetes.
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PMID:Type II diabetes after combined kidney and pancreas transplantation for type I diabetes mellitus and end-stage renal disease. 899 82


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