Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028754 (obesity)
 124,988 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

[4-14C]-Dehydroepiandrosterone and [7 alpha-3H]-Dehydroepiandrosterone sulphate were injected simultaneously to normal and obese female subjects. The percentage recovery of 14C and 3H radioactivies in dehydroepiandrosterone sulphate, androsterone sulphate, etiocholanolone sulphate, androsterone glucuronoside and etiocholanolone glucuronoside was determined in the day-to-day urine collections for 72 hr. Results showed a normal total 3H recovery and a poor 14C recovery in urinary conjugates of obese patients. The rate of appearance of 3H activity was not identical in the individual metabolites of normal subjects, and it was not normal in obesity. Overweight subjects exhibited an acceleration in [7 alpha-3H]-Dehydroepiandrosterone sulphate metabolism to androsterone glucuronoside. The observation regarding the rate of appearance of urinary conjugates bearing 14C isotope correlate with our previous finding in which a glandular overproduction of free dehydroepiandrosterone was found and an uptake of this steroid by the adipose tissue was suggested. Our results showed that the poor recovery of 14C radioactivity in urine of obese female subjects was not an aspecific consequence of illness.
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PMID:Dynamic appearance of [4-14C] dehydroepiandrosterone and [7 alpha-3H] dehydroepiandrosterone sulphate metabolites in urine of normal and obese female subjects. 13 96

Unconjugated dehydroepiandrosterone has been isolated from human abdominal adipose tissue and identified by double isotope derivatization and recrystallization to constant isotope ratio. Gas chromatography with electron capture detection revealed an actual dehydroepiandrosterone concentration between 0.32 to 2.82 mug/g in adipose tissue of normal and overweight subjects. The approximate dehydroepiandrosterone content of the total adipose tissue mass varied between 30 and 173 mg in subjects with severe obesity.
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PMID:Dehydroepiandrosterone concentration in adipose tissue of normal and overweight subjects. 13 17

In 1000 cases of sterilization by laparoscopic tubal electrocoagulation under general anesthesia with endotracheal intubation, no pregnancies have occurred in the follow-up period ranging from 5 to 57 months. The patients ranged from 17 to 50 years with a median of 31 years. 85% of the cases were done as outpatients; the surgical technic used was the standard 2 incision of Steptoe. 16.5% of the patients had had previous abdominal surgery; obesity was not considered a contraindication. There were 30 significant complications, the most common of which was mesosalpingeal bleeding, which occurred in 17 patients. Uterine perforation occurred in 9 patients, the Veress needle was inserted into the stomach of 2 patients. There was 1 traumatic transverse colon injury and 1 perforation of the sigmoid colon. The 3% complication rate of this study falls within the 0-8% reported in the literature. The complication rate falls as physician experience increases; in the last 42 consecutive months no major complications requiring celiotomy have occurred.
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PMID:Sterlization by laparoscopic tubal electrocoagulation a report of 1000 private patients. 13 91

Replies to a questionnaire showed that, amongst 180 women delivered in The London Hospital, 48% experienced backache during pregnancy; in one third of these it was severe. The prevalence of back pain increased with both increasing age and increasing parity, and it was difficult to separate the relative contributions of these two factors. No evidence was found of an association between backache during pregnancy and height, weight, 'obesity index', weight gain, or baby's weight. Analysis of aggravating and relieving factors indicates some differences between backache in the pregnant and 'mechanical' back pain in the non-pregnant. Slightly less backache was reported amongst patients attending antenatal physiotherapy classes but the figures do not provide clear evidence of any protective effect of this attendance.
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PMID:Backache in pregnancy. 14 Oct 93

Two patients are described in whom arthritis following intestinal bypass surgery for obesity was associated with the presence of circulating immune complexes (CLC) and HLA B27. The arthritis was characteristically intermittent and controlled by low dose prednisone, indomethacin, and tetracycline therapy. The findings suggest that immune complexes play a role in the pathogenesis of arthritis associated with condition, and that perhaps the association with HLA B27 may predispose to the development of this complication.
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PMID:Intestinal bypass arthritis: association with circulating immune complexes and HLA B27. 14 52

A case-control analysis was done of 19 cases of uterine perforations which occurred during laparoscopic sterilization at Gardy Memorial Hospital in Atlanta, between February 1, 1974, and January 31, 1976. The over-all perforation rate, 30.4 per 1,000 procedures, is three to 30 times that commonly reported for dilatation and suction or sharp curettage (D&C) of the uterus. Case women were 10.4 times more likely than control women to combine two of the following three characteristics: age greater than 34, parity greater than 4, and obesity greater than 20 per cent above the ideal body weight for height. Surgeons with fewer months of formal Ob/Gyn training were no more likely than their relatively more experienced colleagues to perforate the uterus. No other risk factors were delineated. It is believed that the perforation rate, higher in this study than in earlier ones, reflects better ascertainment of perforations. The bleeding site was always visualized with the laparoscope in this series.
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PMID:A case-control study of uterine perforations documented at laparoscopy. 14 36

The aetiological factors concerned in the production of paraumbilical and epigastric hernias have been reviewed along structural--functional lines. A positive relation between the aponeurotic pattern and herniation was demonstrable at operation in 25 patients with paraumbilical or epigastric hernias. The effect of abdominal distension, obesity, and straining are discussed. A new type of surgical repair planned on this basis is described. The preliminary results obtained with this technique are reported, with a discussion of other previously described types of surgery.
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PMID:A new concept of the aetiology and surgical repair of paraumbilical and epigastric hernias. 14 44

Using experimental models of various disease states, the ability of the isolated perfused working rat heart to withstand and recover from a period of severe ischemia was investigated. The results revealed that the coexistence of a diabetic state, obesity, or left ventricular hypertrophy increased the susceptibility of the hearts to ischemic damage and reduced the rate or the extent of postischemic recovery. In contrast, hearts obtained from moderately hypertensive rats exhibited a greater resistance to, and a superior recovery from, ischemia than did hearts obtained from normotensive controls.
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PMID:Myocardial susceptibility to ischemic damage: a comparative study of disease models in the rat. 15 26

Amongst 22 patients with corrected left-to-right shunts, a diminution in heart size and reduction in central pulmonary arteries and pulmonary plethora was found in about half the patients. A good operative result can be expected, particularly in younger patients with less severe lesions, where the vessels had not been subjected to a high pressure for a long period. The failure of vessels to return to normal is assurmed to be due to changes in the vessel walls. Possible causes for persistent cardiomegaly are, in addition to persistent shunts, coronary artery disease, obesity, inadequate digitalisation and aortic and mitral insufficiency.
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PMID:[The radiographic appearances following correction of left-to-right shunts (author's transl)]. 15 76

A high abundance of C. p. pipiens and C. p. molestus in the town of Sukhumi and its vicinity was recorded from June to October. According to siphonal indexes the 4-th-stage larvae of these mosquitoes differ from each other rather insignificantly. The females of C. p. pipiens exhibit a high fecundity within a warm period of the year which sharply falls by the autumn. During a two-year experiment with a basement micropopulation of C. p. molestus from a non-autogenous form of C. pipiens there was established a gradual increase in the number of autogenous and stenogamic individuals. At the carbohydrate feeding the majority of the first autogenous females with ripe eggs are at the 3-rd -4-th stage of obesity.
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PMID:[Biological characteristics of mosquitoes of the Culex pipiens complex (Culicidae) in Abkhazia]. 15 12


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