Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report on the preoperative findings in 147 patients with surgically confirmed acoustic neuroma (AN). Gaze nystagmus, spontaneous nystagmus and positional nystagmus were present in 23.1%, 47.5% and 63.0% of the patient, respectively. Pathological findings in ETT, OKP and bithermal caloric test were found in 44.3%, 45.3% and 77.0%, respectively. The ratio of pathological findings in ETT and OKP was larger in the large tumor group than in the small tumor group. Gaze nystagmus to both directions and direction-changing positional nystagmus were also found in the large tumor group. While the correlation between tumor size and CP% in caloric test was slightly significant (correlation coefficient, 0.52) in all 122 patients, it was more significant (correlation coefficient, 0.65) in 16 patients whose tumor origin was surgically confirmed to be the inferior vestibular nerve. These findings suggest that reduced caloric response is caused by compression of the nerve by tumor mass. On the other hand, 6 patients whose tumor originated from the superior vestibular nerve showed no significant correlation between CP% and tumor size.
 ...
PMID:Electronystagmographic findings in 147 patients with acoustic neuroma. 184 78

Findings of electronystagmography in 30 patients with posterior cranial fossa tumor were analysed. Of the 23 cases of CPA tumor, size varied between 0.7-5.0 cm, the ENG showed: (1) The nystagmus occurred in 83% of patients. (2) In ODT, overshoots was showed in 22% of patients. (3) ETT showed type III or IV curves in 55.6% of patients. (4) OKP test decreased in 59% of patients. (5) Caloric test showed canal paresis in 85% of the patients. (6) Abnormal visual suppression test occurred in 60% of patients. (7) Abnormal ABR was found in 89% of patients. We also found that tumor larger than 2.5 cm presented a central type nystagmus (Bruns nystagmus) and involvement of the eye movement system. The electronystagmographic changes of the tumors of cerebellum (3 cases) and brain stem (4 cases) was discussed.
 ...
PMID:[Electronystagmographic changes in patients with posterior cranial fossa tumors]. 803 98

This study was performed in 37 patients with alcohol dependency. The mean age was 46.3 years and mean duration of heavy drinking was 23.8 years. The mean duration of temperance to the initial examination was 21.4 days and that to the second examination was 82.0 days. The results of the test on body sway in patients with alcohol dependency may summarized as follows. In patients with alcohol dependency the length of and the area covered by the body sway were significantly larger than in the normal group (p < 0.05). This significant difference from the normal group disappeared open eyes, but remained with eyes closed (p < 0.05). The Romberg quotients of both the length and the environmental area tended to be larger than the normal group mean (p < 0.05). The oscillation power spectrum obtained with eyes open and that obtained with eyes closed tended to be low at levels below 0.2Hz and high at range of 0.2Hz to 0.5Hz in the right left direction. The power spectrum in the anterior-posterior direction obtained with eyes closed was lower than that in the normal group at levels less than 0.2Hz, and higher than that in the normal group at range of 2.0Hz to 3.0Hz on the first examination. After temperance on the second examination, these significant differences had disappeared at all levels. The results of the present study on ocular movements in patients with alcohol dependency may be summarized as follows. Using the oculomotor test, abnormalities appeared in more than 40% of the test subjects for ETT, OKN, OKAN, VS and lateral gaze nystagmus test. According to the report of Matsuoka in 1979, some head positional nystagmus was noted in about 30% of patients with alcohol dependency. In the present study, the rate of appearance was as low as 8%. Ataxic pursuit, vertical positioning nystagmus, decrease of VS, disturbance of OKN and abnormalities of OKAN were found. These results suggested lesions between the brain stem and cerebellum, especially around the upper and lower vermis of cerebellum. After about 3 months of temperance, each test revealed a tendency towards some improvement, but the disturbance appeared to be fixed in some cases. It was important that some improvement in the oculomotor and the central vestibular system was found after about 3 months temperance. These results are quite promising for treatment and recovery in patients with alcohol dependency.
 ...
PMID:[Neurotological examination of patients with alcohol dependency]. 883 Dec 34