Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Comprehensive computerized oculomotor testing was used to investigate the vestibular function in 9 Russian members of ISS crews 3-9 on days 1 (2), 4 (5) and 8 (9) of return from long-term stay in microgravity (126 to 195 days). The vestibular function was assessed by the static otolith-cervical-ocular reflex, dynamic otolith-cervical-ocular reactions, vestibular reactivity, and spontaneous oculomotor activity. The postflight investigations revealed functional disorders in the peripheral (an increased vestibular reactivity, absent or damped otolith-cervical-ocular reflex), and central (spontaneous typical and atypical nystagmus, gaze nystagmus) vestibular analyzer. The pattern and extent of vestibular disorders after long-term exposure in microgravity were individual by character; however, some of the vestibular reactions, including disappearance or considerable damping of the static otolith-cervical-ocular reflex, exaggerated vestibular reactivity and spontaneous eye movements, displayed consistency.
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PMID:[Effect of long-term microgravity on the vestibular function]. 1740 75

The vestibular function was investigated in 13 Russian crew members of the ISS missions on days 1(2), 4(5), and 8(9) after prolonged exposure to microgravity (126 to 195 days). The static torsional otolith-cervico-ocular reflex was studied, as well as the dynamic vestibulo-cervico-ocular responses, vestibular reactivity, and spontaneous oculomotor activity using videooculography (VOG) and electrooculography (EOG) for simultaneous recording of eye movements. On days 1-2 of return to the gravity (R+1-2), the cosmonauts were found to increase the spontaneous oculomotor activity (floating eye movements, both typical and atypical forms of spontaneous nystagmus, square wave jerks, gaze nystagmus) with the head held in the vertical position. The otolith function during static head inclinations to the right or left shoulder at 30 degrees was suppressed as determined by the inversion or absence, or reduction by half of the amplitude of torsional compensatory eye counter-rolling and the vestibular reactivity during head yaw movements at 0.125 Hz was increased as revealed by a lowered threshold and an increased intensity of vestibular nystagmus. The pattern, depth, dynamics, and velocity of the vestibular function recovery varied with individual participants in the investigation. However, the suppressed otolith functioning in the period of readaptation to the normal gravity was, as a rule, accompanied by an exaggerated vestibular reactivity.
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PMID:Static and dynamic vestibulo-cervico-ocular responses after prolonged exposure to microgravity. 1862 33

To determine the role of the support-proprioceptive factor in the functioning of the vestibular system, in particular the static torsional otolith-cervical-ocular reflex (OCOR), comparative OCOR studies with videooculography recording were performed after a 7-day "dry" horizontal immersion (16 immersion subjects) and after a prolonged (126 to 195 days) exposure to weightlessness (14 ISS cosmonauts). For the first time it was demonstrated that minimization of the support and propripceptive afferentation may results in an inversion or absence of the static torsional OCOR and the development of a positional nystagmus with an inverted reflex. A comparative OCOR data analysis of cosmonauts and immersion subjects has revealed similarity of responses. However, changes in OCOR after immersion were noted in only 60% of subjects, while after space fight, 90% of cosmonauts showed them. Post-flight changes were more frequent, marked and long-lasting.
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PMID:[Effect of a real and simulated weightlessness on characteristics of the static torsional otolith-cervical-ocular reflex]. 2146 59