Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two subacute double-blind cross-over experiments on 40 healthy, young volunteers. The drugs were administered for two week periods. The variables measured were choice reaction time and accuracy, eye-hand co-ordination, divided attention, flicker fusion, proprioception and nystagmus. Chlordiazepoxide lactam, methyloxazepam and oxazepam significantly enhanced the alcohol-induced impairment of psychomotor skills, whereas N-desmethyl-diazepam did so only exceptionally in certain subjects in the choice reaction test. It is concluded that diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlation between the serum level of the agents and the changes in performance were found.
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PMID:Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving. 35 10