Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lead subacetate (0.5g) and 1000 units of vitamin D were given three times a week to four newly-weaned rhesus monkeys. In addition, two animals received only the vitamin D. The poisoned animals had an increase in the urinary excretion of delta-aminolevulinic acid, an elevated content of lead in the blood, and a fall in hemoglobin concentration. Between 6 and 18 weeks the animals suddenly developed ataxia, nystagmus, generalized weakness, and convulsions. At this time the animals were killed by perfusion of fixative and the brain prepared for light and electron microscopic studies. Definite morphological evidence of disease was confined to the central nervous system, except for one animal which showed the characteristic renal inclusions of lead poisoning. All animals showed PAS-positive globules associated with blood vessels and an exudative edema involving the white matter of the cerebral hemispheres and cerebellum. Ultra-structurally, this appeared as a granular precipitate within an expanded extracellular space. Alterations of nerve fibers were not seen in the white matter but axonal swelling was observed in the cerebral cortex. The perikaryon and neuropil appeared normal. The control animals showed no significant cerebral changes.
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PMID:Experimental acute lead encephalopathy in the juvenile rhesus monkey. 420 57

Recognized specific risks of industry considered.Under Section 73, Factory and Workshop Act, certain diseases contracted in a factory or workshop are notifiable by medical practitioners to the Chief Inspector of Factories.Lead poisoning, epitheliomatous and chrome ulceration and anthrax-considered in detail.Effects of inhalation of dust in the causation of silicosis and asbestosis. Relation of these diseases to tuberculosis. Reason to believe that a large number of dusts of different characters will create pathological changes in the lung.Other diseases included in the Schedule under the Workmen's Compensation Act, e.g., nystagmus and dermatitis.Common risks, i.e., shared by the general non-industrial population, incurred by workers.Direct supervision of workers in industry.The sphere and work of a works medical officer. The effects of National Health Insurance on such service. Co-operation between panel and works doctors. Far-reaching effects of the services rendered by works medical officers.Periodic medical inspection under regulations for dangerous trades. Advice given on all medical matters.The charge that industry raises the cancer incidence considered. Means of controlling early recognition and treatment include some non-industrial cases of cancer.Anthrax in industry led to the introduction into the country of Sclavo's serum. Disinfection of wool protects the consumer.First-aid training in factories gives protection in the home.It is suggested that well-organized industry is a centre radiating the principles of preventive medicine.
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PMID:The Influence of Industry on Public Health. 1998 74