Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The GABAergic drug baclofen and the cholinergic drug physostigmine were administered to patients with upbeat and downbeat nystagmus. Baclofen (orally, 5 mg three times daily) reduced nystagmus slow phase velocity and distressing oscillopsia by 25-75% in four out of five patients (two upbeat nystagmus; two downbeat nystagmus). Physostigmine (1 mg single intravenous injection) increased nystagmus in five additional patients with downbeat (1) or positional downbeat nystagmus (4) for a duration of 15-20 minutes. The different interactions of baclofen and physostigmine on neurotransmission subserving vertical vestibulo-ocular reflex could account for these effects. The response to baclofen appears to be a GABA-B-ergic effect with augmentation of the physiological inhibitory influence of the vestibulo-cerebellum on the vestibular nuclei. Similarly baclofen has an inhibitory effect on the velocity storage mechanism. Cholinergic action may cause the increment of nystagmus by physostigmine.
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PMID:The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. 165 96

Behavioral state organization was studied in the caudal portion of chronically maintained cats with transections at the ponto-medullary junction or midpontine level. The cats spent most of their time in a 'quiescent state.' This state was periodically interrupted by 'phasic activations.' During quiescence, ECG and reticular unit activity rates were low and regular. EMG levels resembled those seen during non-REM sleep in intact cats. During phasic activations, unit activity in the nucleus gigantocellularis and neck EMG activity increased to levels seen in the intact cat during active waking. Gross postural changes, vestibular slow phase head nystagmus and head shake reflexes could be observed at these times. No periods of neck muscle atonia were observed in either state. No periods of brain-stem controlled rapid eye movements (REMs) occurred. Unit activity patterns similar to those seen in the intact cat during REM sleep were never observed. Physostigmine administration did not produce REM sleep signs, but rather, triggered an aroused state. Phasic activations occurred in a regular ultradian rhythm, with a period similar to that seen in the REM sleep cycle. We conclude that the chronic medullary cat retains primitive aroused and quiescent states, but does not have any of the local signs of REM sleep. However, the medulla does have the capability of generating ultradian rhythmicities which may contribute to the control of the basic rest activity cycle and the REM, non-REM sleep cycle.
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PMID:Behavioral states in the chronic medullary and midpontine cat. 241 85

Caloric nystagmus patterns associated with ocular dysmetria, ocular flutter or flutter dysmetria were studied in ten patients being in a vegetative state, among whom were 9 patients with head injury and 1 with complications caused by a grand mal status. Brain damage was complicated by hypoxemia and especially by brain stem herniation. It was more often observed in very young children and appears to be associated with a poor clinical course. Physostigmine seems to have an activating and provocating effect on these saccadic oscillations. In view of Zee and Robinson's hypothesis on the pathophysiology of saccadic oscillations, it is suggested that these nystagmus patterns may reflect a disturbance of brain stem midline structures (pausing neurons) or an abnormal supranuclear (cerebellum) control.
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PMID:Saccadic oscillations associated with the quick phases of caloric nystagmus in severe diffuse brain damage. 632 66