Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For the purpose of investigating the ability of posttraumatic oculomotor nerve to restore its function, animal experiments were carried out using 22 mongrel adult dogs weighting 6.5 kg on the average. Anesthesia was induced with 30 mg/kg of intervenous Nembutal, and craniectomy performed. An injury was delivered to the oculomotor nerve at about 2 mm centrally from the rim of the tentorium which was reached by retracting the temporal lobe under the oprating microscope, then the wound was closed. The animals were devided into three groups according to the severity of trauma; the first group of 5 dogs received complete neurotomy, the second group of 11 dogs had their nerve severed with about 10% left at its medical lower part and secured by one-stitch using 9-0 suture, and the third group of 5 dogs were subjected to cut of less than half of the upper, lower, or lateral part of the nerve. Observations with time were made of eye movement, light reflex and others for up to 2 years and 6 months, one year, and 2 years and 5 months in the three groups respectively. After conducting the caloric nystagmus test by introducting cold water (20 degrees C) into the external auditory meatus, the site of surgery was dissected for histological examination employing Holmes' stain.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Oculomotor nerve anastomosis: an experimental study in the dog]. 652 26

Intact pigeons (n = 64) were rotated in the dark in the horizontal plane at different orientations relative to the axis of rotation. The overall patterns of changes in nystagmus of the eyes arising as a result of displacement of the otolith membranes in several directions were analyzed. In ten pigeons, all changes in nystagmus (type 1 general patterns) could be explained in terms of the dynamics of peripheral neuron activity and non-specific (identical for all combinations of interacting inputs) central influences. In the remaining pigeons, part of the change in nystagmus (type 2 general patterns) was associated with central influences which were not identical for different combinations of interacting inputs. Repeated unusual combinations of vestibular stimuli and subsequent treatment with Nembutal transformed type 2 general patterns into type 1 general patterns. These data provide evidence for the fragmentary control of eye movements, whereby there is selective (fragmentary) modification of only some (individually specific) combinations of canal and otolith signals out of the whole set of vestibuloocular responses arising in response to stimulation of paired vestibular inputs; modification is mediated by changes in the sign of otolith influences on the canal components of these responses.
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PMID:Fragmentary control of vestibuloocular responses. 1087 33