Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 71-year-old man with bilateral medial longitudinal fasciculus (MLF) syndrome and paralytic pontine exotropia caused by an infarction of the midbrain tegmentum was reported. He suddenly noticed a diplopia and gait disturbance, and visited our clinic. Neurological examination revealed that this right eye was slightly abducted in the primary position. On horizontal gaze, outwardbeating nystagmus of the abducted eyes was observed, bilaterally. The adduction of the bilateral eyes was severely disturbed and the abduction of the left eye was slightly restricted, while the convergence was normal. T2-weighted magnetic resonance imaging revealed high signal intensity area in the medial portion of the midbrain tegmentum, which indicated an infarction. Several cases showing bilateral MLF syndrome with exotropia have been reported, but a case whose lesion was shown in the midbrain has not been reported so far. The present case suggests that paramedian pontine reticular formation (PPRF) is not confined to pons but expands to midbrain.
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PMID:[Lesion of the bilateral MLF and unilateral paramedian pontine reticular formation, caused by an infarction in the midbrain tegmentum]. 837 Feb 10

Medial medullary infarct (MMI) is a rare type of brain stem infarction. Its clinical picture was characterized by contralateral hemiparesis, deep sensory disturbance, and ipsilateral hypoglossal paresis, but conjugate deviation or nystagmus is uncommon as initial symptom. Case 1: A 73-year-old man developed vomiting and vertigo. Examination revealed right conjugate deviation and horizontal nystagmus beating toward the left side, and numbness on his right upper limb,but no hypoglossal nerve palsy. Cranial MRI demonstrated an infarction in the left paramedian region of the upper medulla and thrombus of the left vertebral artery. Case 2: A 74-year-old man suffered from dizziness and nausea. He showed left conjugate deviation and right-beating horizontal nystagmus without Horner syndrome or hypoglossal nerve palsy. MRI disclosed an infarction in the right upper medial medulla. MRA revealed the right dissecting vertebral artery. Case 3: A 71-year-old man developed vertigo when watching at TV. He showed transient left conjugate deviation and transient motor paresis on the left upper limb. MRI showed the thickened wall of the right vertebral artery but no abnormal ischemic lesion. Digital subtraction angiograms revealed the dissecting right vertebral artery. All ischemic events limited to the upper third of the medulla were caused by the vertebral artery lesions, and prognosis was good. The unilateral MMI lesion in the nucleus prepositus hypoglossi and/or the medullary reticular formation caused contralesional shift of the eyes and ipsilesional nystagmus. The upper MMI will be characterized by a triad of contralateral hemiparesis, deep sensory disturbance and abnormal ocular motor findings.
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PMID:[Conjugate deviation in ischemia of medial medullary oblongata--report of three cases]. 1737 Jun 54