Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spontaneous eye movements were recorded before and after a microinjection (0.1-0.2 microliter) of either APV (an NMDA receptor antagonist) or NBQX (a non-NMDA receptor antagonist) into the nucleus prepositus hypoglossi (NPH) of the alert cat. A unilateral injection of APV caused bilateral failure of the horizontal gaze-holding system: in the light, each saccade was followed by a post-saccadic drift. A unilateral injection of NBQX caused no sign of gaze-holding failure; in the light, spontaneous eye movements were unaffected; in complete darkness, a nystagmus with linear slow phases directed towards the injected side was observed. We conclude that NMDA receptors of the NPH neurones are involved in the gaze-holding system.
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PMID:NMDA receptors are involved in temporal integration in the oculomotor system of the cat. 791 92

To investigate the role of the N-methyl-D-aspartate (NMDA) receptor in the vestibular periphery, vestibular compensation in the guinea pig was studied following chemical unilateral labyrinthectomy by osmotic pump administration of streptomycin sulfate (SM) with or without D-2-amino-5-phosphonovalerate (D-APV), one of the NMDA receptor antagonists. All animals administrated SM (SM group) or SM and D-APV (SM + D-APV group) showed spontaneous nystagmus and head tilt. The maximum degree of yaw head tilt in the SM + D-APV group was statistically smaller than that in the SM group. Moreover the time constant for head tilt in the SM + D-APV group was statistically shorter than that in the SM group. These results indicate that the NMDA receptor in the vestibular periphery influences vestibular compensation after unilateral labyrinthectomy.
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PMID:The role of N-methyl-D-aspartate receptor in the guinea pig inner ear after unilateral labyrinthectomy. 975 59