Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and lid reflexes, remained active. Systolic, diastolic, and pulse pressure were slightly increased, with associated tachycardia and tachypnea. A dose of 0.75 mg/kg produced anesthesia for an average of 26 (14 to 53) minutes. Alternating nystagmus was present for several hours and associated with dreams and/or visions that were pleasing to most patients. Six patients, however, had unpleasant dreams for up to 24 hours. One patient given an excessive dose (4.65 mg/kg) was cataleptic, amnesic, and analgesic for 6 days. The occurrence of unpleasant dreams and aberrations in over 20% of the patients suggests that the drug probably has little usefulness in anesthesia. However, the extreme safety of the drug (an LD50 equal to some 20 to 40 times the ED50) and the prolonged analgesia justified clinical testing. There was no evidence of metabolic or systemic organ system change from any of the clinical laboratory studies.
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PMID:Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). 0 21

Alternating nystagmus is a spontaneous nystagmus which changes in direction without any external influence. In the literature this phenomenon has so far been described in 90 cases; in 12 of these, the nystagmus had a congenital origin. In contradistinction to the congenital type, the acquired type of alternating nystagmus is in most cases caused by a central nervous system disorder. We found the phenomenon of alternating nystagmus in 21 cases, in 15 of which it was congenital. The nystagmus was observed by means of electronystagmography. Differences were found between the two nystagmus types. The characteristics of alternating nystagmus are discussed.
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PMID:Nystagmus alternans. 44 21

Optokinetic nystagmus (OKN) is useful in evaluating visual function objectively, and the classical black-and-white-striped OKN drum is being replaced by video or computer monitor. However, the examinee may feel fatigue during test because of high contrast of luminous pattern from monitor. This paper suggests a plan to reduce eye fatigue of participant by decreasing contrast of patterns without reducing OKN response. Alternating black and white stripes are shown on flat-panel liquid-crystal display monitor and moved horizontally to evoke OKN of the examinee, and the OKN wasW observed through electrooculography (EOG). Eye fatigue was estimated from the number of eye blinking, along with dry eye questionnaire according to the contrast of the black and white stripes. White stripes are shown as 300cd/m2, and gradual decrement in contrast by 75%, 50%, and 25% were given to investigate the effect of the contrast on the eye fatigue and the OKN. Blinking of the eye was recorded as a video clip and was analyzed by image processing to count the number of blinks while measuring OKN. Experimental results show that incidence of nystagmus does not substantially change with the change of contrast in stimulus pattern but the eye fatigue decreased by the reduction of the contrast. In conclusion, the examinee may choose the contrast option for the OKN test to reduce the stress onto their eye, without affecting the test result.
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PMID:Analysis of computerized optokinetic nystagmus induction and effect of contrast on ocular fatigue. 2906 92