Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four test medications were randomly examined in 25 volunteers for the depressant effect on the labyrinth during stimulation in a rotation chair as well as in a parallel swing. The medications, placebo (pl), Domperidone 30 mg (D), Cinnarizine 40 mg (C) and Touristil 40 mg + 30 mg (C+D), were tested at 1-week intervals, the duration and amplitude of nystagmus having been recorded 15 min, 30 min, 1, 2, 3 and 4 h after intake of the medication. In both tests Touristil (C+D) was significantly (p less than 0.01) to very significantly (p less than 0.0001) more potent, more rapid, and longer working than placebo and the separate components (C) and (D). In addition the working of Touristil was specifically superior to Cinnarizine, when given separately. It appears that the new preparation Touristil approaches the profile of the ideal drug against motion sickness more closely than any other medication.
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PMID:The combined effect of cinnarizine and domperidone on vestibular susceptibility. 349 59

Domperidone, administered to rabbits, is able t reduce the duration of a rotation-induced nystagmus. In human volunteers a similar effect was found in a double-blind study, in which single doses of 10, 20 and 40 mg were given orally. As electronystagmographic recordings were made during the rotation test at different time intervals after drug intake, the different dosages became comparable. The reduction of the nystagmus duration proved to be dose-dependent, whereas the peak velocity of the slow nystagmus component remained unchanged. The strongest effect of the drug appeared 60 min after intake, the effect lasted about 4 h. A mechanism of action different from that of cinnarizine and flunarizine is assumed because these drugs likewise influence the duration and the slow velocity component of nystagmus.
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PMID:Vestibular pharmacology of domperidone in rabbits and man. 697 26