Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Basilar impression was found in three members of one family. The mother showed an asymptomatic deformity, her eldest son complained of headache, drop-attacks, nystagmus, unilateral ophthalmoplegia, and ataxia; the middle son presented with headache, nystagmus, and hemiparesis. Magnetic resonance (MR) imaging demonstrated convexobasia of various degrees with elevation of the upper spine and malformation of the occipital bone. The medulla oblongata and the pons were flattened and dislocated backward in two cases. Chiari malformation was present in one case and mild hydrocephalus in another. A comparison of MR with CT imaging demonstrates some advantages of the former method in the assessment of the neural structures directly involved in basilar impression.
 ...
PMID:MR imaging of familial basilar impression. 647 Feb 65

An unusual case of severe head trauma is reported with postoperative 'total' ophthalmoplegia of the right eye. Subsequent recovery led to an apparent transposition of right medial and right lateral rectus function. Optokinetic stimulation induced convergence nystagmus when the target was moved to the patient's left, and a divergence nystagmus when the target was moved to the patient's right. In addition, attempted lateral gaze induced ipsilateral pupillary constriction. Aberrant regeneration involving the right abducens and right oculomotor nerves is proposed as the underlying mechanism.
 ...
PMID:Aberrant regeneration involving the oculomotor and abducens nerves. 647 11

We describe a patient with an isolated mesencephalic dorsal tegmental infarct affecting the oculomotor nuclear complex and medial longitudinal fasciculus, documented by high-resolution computed tomography, after undergoing percutaneous transluminal coronary artery angioplasty. Clinically, the patient exhibited bilateral ptosis, bilateral internuclear ophthalmoplegia, transient convergence retractory nystagmus, and minimal somnolence. We believe the combined clinical and radiological findings favor the presence of a caudal, dorsal, and paramedian embolic infarct in the territory of the paramedian branches of the mesencephalic artery as the most likely mechanism for these exceptional findings and correlate them with Warwick's scheme of the oculomotor subnuclei.
 ...
PMID:Oculomotor nuclear complex infarction. Clinical and radiological correlation. 647 33

Unilateral or bilateral limitation of adduction with jerk nystagmus of the abducting eye occurred after a weakening operation of the medial rectus muscle in five patients aged 9 to 39 years. The nystagmus waveform was indistinguishable and the clinical findings were similar to those in internuclear ophthalmoplegia. Persistence of the abducting nystagmus after occluding the adducting fellow eye in four of the five patients reflected a continued attempt of the central nervous system to increase neural activity to the paretic eye. This hypermetric response disappeared after several days of patching of one eye, only to reappear after removal of the patch. These observations suggested that the generation of abducting nystagmus in conjunction with medial rectus muscle palsy of the fellow eye does not necessarily depend on lesions in the median longitudinal fasciculus, but may also be caused by a gain-step mismatch of the saccadic generation system.
 ...
PMID:Pseudo-internuclear ophthalmoplegia after surgical paresis of the medial rectus muscle. 649 14

It has generally been assumed that the oculomotor system is not involved in amyotrophic lateral sclerosis (ALS). However, reports from the literature and recent experience with patients indicate that there are oculomotor abnormalities in some ALS patients. These appear to fall into two main categories. One group of patients has signs that reflect damage or degeneration in cortico-oculomotor pathways. These patients have problems in generating voluntary saccades, convergence and pursuit eye movements. It should be possible to corroborate deficits in ocular pursuit in these patients with deficits in visual suppression of the vestibulo-ocular reflex (VOR) and in optokinetic nystagmus (OKN). A second group of patients, much less common than the first, has a more global type of ophthalmoplegia, probably reflecting a loss of neurons in and around the ocular motor nuclei. There are probably also patients with mixed types of involvement. Testing the vestibulo-ocular reflex (VOR) in conjunction with other tests of visual-oculomotor function should help in identifying the deficits. The relative incidence of the various types of deficits is not known and is a subject for study. It would also be of interest to correlate the changes that are present in the oculomotor system of patients with ALS with deficits in other parts of the somatic motor system.
 ...
PMID:Eye movements in amyotrophic lateral sclerosis. 658 14

The variety of drug induced patterns of pathological eye movements is reviewed with emphasis on hydantoins, barbiturates, carbamazepine, benzodiazepines, amitriptyline and alcohol. These different substances may be analogous or distinct in their site of action within the labyrinths, brain stem and cerebellum. Ocular oscillations are described in correlation to drug uptake or serum levels such as positional, downbeat, gaze evoked, periodic alternating nystagmus as well as saccadic pursuit, slowing down of saccades, alteration of VOR gain or suppression by fixation, internuclear and complete ophthalmoplegia. Most of the ocular motor disturbances are possibly due to a pharmacologically induced transient dysfunction of the vestibulo-cerebellar flocculus loop.
 ...
PMID:[Pharmacologically-caused eye movement disorders--differential diagnosis and mechanisms of action]. 660 6

Two cases of myasthenic pseudointernuclear ophthalmoplegia are reported. The diagnosis of this rare peripheral oculomotor syndrome is established on the variability of the clinical signs, their improvement by pharmacological testing, the combined impairment of convergence, the usual association of ptosis, and in some cases the presence of specific electromyographic signs. The nystagmus of the abducting eye could result from a selective damage to the tonic muscle fibres mediating fixation, the phasic fibres (performing saccades) being spared.
 ...
PMID:[Myasthenic internuclear pseudo-ophthalmoplegia]. 664 6

A case of left internuclear ophthalmoplegia combined with downbeat nystagmus and right incyclorotatory nystagmus on left downward gaze, left exotropia and skew deviation is presented. All signs subsided completely within about 3 months after the onset of the disease. The etiology was possibly of vascular origin. The potential site of the lesion causing these oculomotor signs is discussed.
 ...
PMID:Internuclear ophthalmoplegia associated with ipsilateral downbeat nystagmus and contralateral incyclorotatory nystagmus. 665 84

Quantitative electro-oculographic recording techniques were used to analyze four characteristic eye movement abnormalities in 21 patients with internuclear ophthalmoplegia (INO). The frequency of each of the abnormalities was determined to suggest a pattern that is the most sensitive in detecting the syndrome of INO. Slowing of the adducting saccade was the most frequently found abnormality, being present in all patients. The other characteristic eye movement disorders were found less frequently: dissociated nystagmus at 30 degrees of eccentric gaze, dysmetria of the abducting eye, and limitation of adduction. The most sensitive pattern for detecting an INO seems to be slowing of the adducting saccade combined with either dissociated nystagmus or dysmetria of the abducting eye. Limitation of adduction was seen much less frequently.
 ...
PMID:Analysis of characteristic eye movement abnormalities in internuclear ophthalmoplegia. 682 62

Eye movements in a patient with Fisher's syndrome were examined clinically and documented photographically when palsies were most severe and on repeated occasions during the recovery period. Two recordings of horizontal eye movements were made using the infrared reflection method. Particular attention was paid to signs indicating supranuclear eye movement disorders. We also reviewed cases in which signs suggesting brain-stem involvement were reported. Mild ptosis in the presence of severe ophthalmoplegia, preservation of Bell's phenomenon despite paralysis of voluntary upward gaze, conjugate palsies of vertical gaze, and horizontal dissociated nystagmus have been found relatively often. Convergence spasm was reported only once, however, and there were no prior reports of rebound nystagmus or vertical vestibulo-ocular reflex disorder.
 ...
PMID:Supranuclear eye movement disorders in Fisher's syndrome of ophthalmoplegia, ataxia, and areflexia. Report of a case and literature review. 686 Jan 74


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>