Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 3-year-old boy had a history of nausea and vomiting for 1 month. After two episodes of tonic cramp, he became drowsy and then semicomatous. Physical examination on admission revealed a dehydrated semicomatous boy with fixed, dilated pupils of equal size, horizontal nystagmus, and left hemiparesis with bilateral Babinski signs. Plain skull films showed a separation of coronal and sagittal sutures. A high density area surrounded by cyst was found in the pineal region in CT scan. Angiography demonstrated stretching of the posterior choroidal arteries, backward displacement of the Galen, the posterior mesencephalic and the precentral vein. The right occipital transtentorial approach was selected to remove the tumor totally. Histology revealed epidermis, hair follicle, sebaceus and sweat glands, columar gland, bone, cartilage, muscle, fatty tissue, nervous tissue, and connective tissue, indicating a pineal teratoma. There was no evidence of germinoma.
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PMID:[Pineal teratoma--case report (author's transl)]. 44 May 19

Pingandan was a secret prescription for treatment of stomach upset, nausea and vomiting for emperors in the Qing Dynasty of China. This study was to compare the effects of Pingandan with those of scopolamine and dramamine on motion sickness (MS) and nystagmus. Fourteen cats were tested in a parallel swing (0.22 Hz, 3.9 m/S2) for 20 min, and then in a rotating chair (10 degrees/S2, 20 rpm) for 1-2 min. The effects of scopolamine 1 mg, dramamine 25 mg and three doses of Pingandan 50x, 30x, 10x of 0.45 g/kg were observed and compared to placebos. These drugs or placebos were administered to each cat 30-60 min prior to the tests. The post-rotary nystagmus and MS symptoms were recorded. The Suri's scale for MS severity, Latin square and double blind techniques were used. The interval between any two tests was 2-5 days. It was found that Pingandan 50x and scopolamine 1 mg were more effective than placebos in reducing MS symptoms (P less than 0.01) and suppressing slow phase velocity of nystagmus (P less than 0.05), while Pingandan 30x significantly reduced MS symptoms only (P less than 0.01). Pingandan 10x and dramamine 25 mg had no anti-MS effect. Chinese medicine Pingandan is an effective anti-MS drug.
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PMID:Experimental research on antimotion sickness effects of Chinese medicine "pingandan" pills in cats. 161 17

An 8-year-old boy had nausea and vomiting associated with nystagmus, ataxia, and dysarthria of acute onset. Three years later he had a mass in the anterior mediastinum as a result of Hodgkin disease of mixed cellularity. This association of paraneoplastic cerebellar degeneration with Hodgkin disease has been described in adults.
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PMID:Paraneoplastic syndrome manifesting as chronic cerebellar ataxia in a child with Hodgkin disease. 173 28

Thirty patients with histologically confirmed posterior fossa ependymomas operated on between January 1976 and December 1988 were reviewed. The median age was 44 years (range, 1-69 yr). There were 7 children (aged 5 yr or younger) and 23 adults (aged 16 yr or older). There were 18 female patients and 12 male patients. Headache, nausea and vomiting, and disequilibrium were the most frequent symptoms. The most common findings were ataxia and nystagmus. Gross total resection was performed in 8 patients (27%), subtotal resection in 21 patients (70%), and biopsy in only 1 patient (3%). Tumors were low grade in 73% and high grade in 27%. Twenty-seven patients underwent posterior fossa radiotherapy (median dose, 5400 cGy). Fourteen patients also underwent spinal irradiation (median dose, 3520 cGy). Age was the only significant prognostic factor identified (P less than 0.01). The 5-year survival rates were 76% for adults and 14% for children. All 14 patients who died had recurrent or residual tumor at the primary site. This review suggests that in patients with primary posterior fossa ependymomas the following is true: 1) the young patient (5 yr old or younger) has a poor prognosis; 2) there was a trend toward a better 5-year survival rate with a gross total resection; 3) if recurrence occurs, it will be at the primary intracranial site; and 4) symptomatic spinal seeding does not occur frequently.
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PMID:Posterior fossa ependymomas: report of 30 cases and review of the literature. 187 43

Ventriculolumbar perfusion chemotherapy with methotrexate (MTX) and cytosine arabinoside (Ara-C) was performed in six patients with meningeal dissemination of malignant disease. Ten mg of MTX and 40 mg of Ara-C were injected via Ommaya reservoir every 12 hours for 3 days. During perfusion, we observed nausea and vomiting, low grade fever, confusion, nystagmus, paresthesia or numbness of the lower extremities, and multicranial nerve impairment, which disappeared soon after perfusion chemotherapy. After treatment, one patient developed bacterial meningitis, and two developed MTX-induced interstitial pneumonitis, which was cured by steroid therapy. Signs and symptoms due to involvement of the cerebrum, cranial nerves and spinal cord or spinal roots, improved more than by standard intrathecal chemotherapy. Laboratory cerebrospinal fluid (CSF) findings, i.e., cell count and cytological appearance, also improved more than by standard intrathecal chemotherapy. EEG, CT scan and MRI data revealed a worsening of EEG findings in one patient, and a small lesion on MRI, which was not seen by CT scan, disappeared after treatment in two patients.
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PMID:[Ventriculo-lumbar perfusion chemotherapy with methotrexate and cytosine arabinoside for meningeal dissemination of malignant disease]. 205 75

Cumulative phase nystagmic responses to caloric stimulation was examined in 72 healthy subjects without any balance disorders and aged 15-55 years. After detailed problem-oriented anamnesis had been taken, vestibular apparatus function was examined by caloric water stimulation using its standard values (44 degrees C, 30 degrees C and if necessary, 18 degrees C) together with electronystagmographic registration of nystagmus. During each labyrinth caloric stimulation, data on vertigo, nausea and vomiting have been recorded. Results have shown that there were 37-74 nystagmic jerks to caloric stimulation, and 24-62 to cold stimulation.
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PMID:[Electronystagmographic values of the caloric vestibular response in the cumulative phase in healthy people]. 207 5

A 46-year-old healthy man suffered from sore throat, fever and right otalgia. On the next day, he developed hoarseness and difficulty in swallowing. On the 6th day, he suffered from vertigo, nausea and vomiting associated with unsteady gait. He was admitted to the otorhinolaryngology department in our hospital and pointed out to have vesicles at his right ear. On the 13th day, he was referred to our service. On admission, no vesicles were noted at the right ear or pharynx. Neurological examination revealed mild nuchal rigidity and marked hoarseness, associated with poor elevation of soft palate and loss of pharyngeal reflex on the right side. He also had horizontal-clockwise rotatory nystagmus in primary gaze and ataxic gait. There was no hearing loss nor facial palsy. No other abnormal neurological findings were noted. The cerebrospinal fluid showed pleocytosis associated with increased protein. The viral antibody titre for herpes zoster was significantly elevated on 18th day in serum as well as in cerebrospinal fluid. Vertigo, nausea, vomiting, ataxia and difficulty in swallowing were all disappeared by the 25th day, whereas hoarseness was improved but still noted 6 months later. Among cranial nerves, trigeminal and facial nerves are the most commonly affected in patients with herpes zoster, but there have been a few reported cases of the 9th and 10th cranial nerve involvement in the literature. In these previously reported cases, all were written before the era of serological diagnosis, and herpes zoster was diagnosed by the vesicles at the ear or pharynx.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of unilateral VIIIth, IXth and Xth cranial nerve involvement with herpes zoster]. 216 88

Computed tomography (CT) allows earlier diagnosis of intracranial cavernous angioma than was formerly possible. However, cerebellar lesions are uncommon. Cerebellar cavernous angioma with hemorrhage was diagnosed in a 54-year-old male who suddenly developed nausea and vomiting, then declined over the following week and developed ataxia and nystagmus. Blood pressure was normal, and he had no history of hypertension or hemorrhagic diathesis. Precontrast CT revealed an irregularly-shaped, hyperdense lesion in the left cerebellum and an associated hematoma. Injection of contrast medium did not significantly enhance the lesion. Vertebral angiography demonstrated only an avascular mass in the cerebellum. A semiliquid hematoma was evacuated and a vascular nodule was removed from the posterior wall of the hematoma cavity. The histopathological diagnosis was cavernous angioma. Nine sufficiently documented reports of cerebellar cavernous angioma are reviewed and the clinical and radiological features of these lesions are discussed.
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PMID:Cavernous angioma of the cerebellum--case report. 247 64

Observations over 28 patients with benign intracranial hypertension, aged from 15 to 50 years, of them 25 women and 3 men, have shown that among possible etiologic factors of benign intracranial hypertension there appeared to be pregnancy in 19 women, respiratory infection--in 3 patients, climacterium--in 2, hypothyrosis--in 2, galactorrhea-amenorrhea--in 1, mild craniocerebral trauma--in 1; 75% of patients had excessive body mass. Among main symptoms of benign intracranial hypertension there were head pains (100%), congestive optic discs (100%), rise of csf pressure (87.5%), nausea and vomiting (80%). In a part of patients there was obnubilation (7), nystagmus (4), damage of the abducent nerve (4), retro-orbital pains (3), transient disturbances of visual functions (fall of visual acuity in 5, defects of visual field in 5). In I woman amaurosis in both eyes remained. The duration of the disease varied from 2 months to 2 years. In 3 women there were recurrences of benign intracranial hypertension.
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PMID:[The symptom of congestive optic disks in the benign intracranial hypertension syndrome]. 279 79

A case of large epidermoid located in the fourth ventricle is presented, and the patient's uncommon symptomatology of bronchial asthma-like episode is discussed. The value of magnetic resonance imaging (MRI) is also emphasized in the diagnosis of intracranial epidermoid. A 41-year-old male noticed nausea and vomiting on getting up in the morning about 5 years ago. This was followed by bronchial asthma-like dyspnea one year later. About one week prior to admission, headache and gait disturbance started. On neurological examination, he had choked disk and horizontal nystagmus at lateral gaze bilaterally. His gait was slightly ataxic. Computerized tomography (CT) showed a low density mass with a sharp and irregular margin in the mid-portion of the posterior fossa. That lesion was not enhanced with contrast medium. The MRI appearance was that of an inhomogenous and low signal intensity mass with a slightly irregular margin on T1-weighted spin echo (SE) sequences using TR500 msec/TR30 msec (TR500/TE30). The tumor extended into the aqueduct upward and the C1 level of spinal column downward. T2-weighted SE sequences using TR2000/TE90 showed an inhomogenous and high intensity mass with an irregular margin more apparent than in normal brain tissue. The patient was tentatively diagnosed as having a large fourth ventricle tumor. Suboccipital craniectomy was carried out on 4, March, 1988. The tumor was removed totally and histologically, it turned out to be epidermoid. He was discharged without neurological deficit 2 months after surgery. First, with respect to clinical symptomatology, as specified by Bailey, it is characterized by difficulty in standing or walking, vertigo, and less constantly, psychic disturbance.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of epidermoid in the fourth ventricle associated with bronchial asthma-like symptom]. 281 68


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