Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The symptoms of infantile strabismus are triggered by fixation, chiefly monocular fixation. On the excluded eye, "occlusion deviations" (elevation, esodeviation, extorsion) are well observed through a "translucent" unilateral cover. These deviations are super-imposed upon a position of rest without fixation which may be an orthoposition, well observed through bilateral translucent occluders. They are caused by a rupture of binocular retinal stimuli which does not mean rupture of fusion (ex: the darkening Bielschowsky test). Electro-oculographic studies confirm the prevalence of adduction during fixation (nystagmus, pursuit, optokinetic nystagmus). This directional asymmetry is typical of the infant's immature system of fixation. In infantile strabismus, it persists because of missing binocular links (corpus callosum--cortex----midbrain) as shown by the study of the so-called congenital monophthalm syndrome (unilateral congenital blindness).
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PMID:[Functional study in early strabismus: translucent screens and electro-nystagmography]. 225 Sep 59

The previously reported nomenclature and clinical characteristics of dissociated vertical deviation have been recorded. The incidence and characteristics of DVD have been determined by evaluation of 1,000 consecutive strabismus or nystagmus patients, and with selected chart study carried out on the 111 DVD patients found in this series. Electro-oculographic studies of selected patients with DVD provided objective evidence of the speed and amplitude of the ocular movements in DVD. Bell phenomenon, strabismus sursoadductorius and the Bielschowsky phenomenon were recorded and compared to clinical findings of strabismus patients with DVD. The technique for the results of surgery for DVD were described. Dissociated vertical deviation was characterized as a component of the overall strabismus picture.
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PMID:Dissociated vertical deviation-a clinical and laboratory study. 702 Feb 16

The Heimann-Bielschowsky phenomenon (HBP) refers to coarse vertical oscillation of the eye with impaired vision. The ocular movements are strictly monocular, occurring only in the eye with amblyopia. The vertical oscillation is of equal velocity in both vertical directions, or may sometimes be greater in the downward than upward direction. HBP develops several years after loss of vision. It can be differentiated from dissociated nystagmus in spasmus nutans, congenital nystagmus and internuclear ophthalmoplegia based on the strict unilaterality, vertical direction and low frequency. Previously, only a few reports described the development of oscillopsia due to HBP after cataract surgery, which resolved spontaneously or responded to gabapentin. However, visual impairments due to diplopia or oscillopsia from HBP after cataract surgery have received little attention. We report a man who developed persistent vertical diplopia and oscillopsia due to HBP after a cataract operation, which markedly impaired his vision.
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PMID:Emergence of diplopia and oscillopsia due to Heimann-Bielschowsky phenomenon after cataract surgery. 1881 21

A 59-year-old man who complained of binocular vertical diplopia after an exploratory laparotomy, complicated by cardiorespiratory arrest during anesthetic induction, was found to have Collier's sign, anisocoria, complete paralysis of upward vertical gaze associated with convergence-retraction nystagmus on attempted upgaze and skew deviation with hypertropia in the left eye without ptosis, and an absent Bielschowsky sign. Magnetic resonance imaging of the brain showed a small lesion in the left paramedian midbrain compatible with microvascular ischemic sequelae. This patient was diagnosed with Parinaud's syndrome (dorsal midbrain syndrome) associated with a vertical strabismus from an unilateral vascular ischemic paramedian midbrain lesion.
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PMID:Parinaud's syndrome due to an unilateral vascular ischemic lesion. 2564 59

A 6-year-old female-neutered vaccinated Cocker Spaniel presented for preadoption neurological evaluation due to abnormal left-eye movements that had been noticed since young age. Clinical examination revealed left-eye cataract with a nonvisible left and a normal right retina on ophthalmoscopy. Neurological examination revealed absent left-sided menace response and cataract-related ipsilateral visual impairment, and intermittent left-sided abnormal eye movements consisted of intermittent, slow, coarse, variable amplitude, vertical movements of the eye that they were giving the impression of random movements of the eye within the globe as it was floating ("wandering" eye) interchangeable with periods of rest. Blood and infectious diseases tests were unremarkable. Magnetic resonance imaging of the brain was unremarkable, whilst cerebrospinal fluid analysis revealed mildly inflammatory in the light of blood contamination. A presumptive diagnosis of meningoencephalitis of unknown origin was established and trial with dexamethasone was performed, however nystagmus remained unchanged 2 weeks post-treatment. Therefore, based on the fact that monocular nystagmus existed since youth and remained static, and the dog was otherwise neurological-sign-free regardless the discontinuation of steroids, the diagnosis of meningoencephalitis was considered as unlikely and a presumptive diagnosis of Heimann - Bielschowsky phenomenon of the left eye due to cataract-related ipsilateral visual impairment was established. This vergence eye movement abnormality also known as searching, wandering or amaurotic nystagmus is a constant or intermittent benign eye movement abnormality mostly related with vision impairment due to ophthalmological or neurological disease. Heimann - Bielschowsky phenomenon is an underreported eye abnormality in veterinary medicine. Although the most common type of eye movement abnormalities seen in veterinary practice is the bilateral conjugate jerk nystagmus, monocular nystagmus representing Heimann - Bielschowsky phenomenon exists in animals, it has been related with partial or complete vision impairment and it should be recognised by the clinicians.
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PMID:Monocular Nystagmus Representing Heimann - Bielschowsky Phenomenon in a Dog With Ipsilateral Vision Loss. 3269 Feb 84