Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An experiment was carried out to examine the effects of TRH on the acquisition of vestibular habituation in guinea pigs. Vestibular habituation was obtained in approximately 12 days by vestibular training of unidirectional velocity steps imposed 30 times daily for 15 days, and was retained for more than 2 weeks even though the daily vestibular training was ceased. When compared with the time to attain the maximum level of the vestibular habituation depicted through decrement of postrotatory nystagmus between control and thyrotropin-releasing hormone (TRH) injection groups, the TRH injection group took significantly longer than the control group. Thus the results have shown that the systemic administration of TRH could result in the retardation of the acquisition of vestibular habituation. This could be due to the depressant action of TRH on the cerebellar neurons.
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PMID:Effect of thyrotropin-releasing hormone on vestibular habituation in guinea pigs. 179 13

Continual administration of thyrotropin-releasing hormone (TRH) (250 micrograms/kg/day) for 14 days using an osmotic mini-pump in unilateral labyrinthectomized squirrel monkeys induced accelerated vestibular compensation. Decrease in total gait deviation counts and reduction of slow-phase eye velocity of spontaneous nystagmus were significantly faster in the TRH-treated group as compared with the control group.
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PMID:Effect of thyrotropin-releasing hormone on vestibular compensation in primates. 308 45

We studied ocular movements in 130 patients with spinocerebellar degenerations. Patients had blurred vision (33.3%), diplopia (40.2%), oscillopsia (18.6%), ocular flutter (22.3%), rebound nystagmus (25.4%), square-wave jerks, (29.2%), macro square-wave jerks (6.2%), and macro saccadic oscillations (10.8%). Electro-oculographic abnormalities included reduction of saccadic velocity, dysmetria, and saccadic smooth pursuit. All the abnormal movements were improved by the injection of thyrotropin-releasing hormone.
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PMID:Bedside and electro-oculographic analysis of abnormal ocular movements in spinocerebellar degenerations: effects of thyrotropin-releasing hormone. 312 69