Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

300 women aged 16-37 received analgesic-sedative preparations for miniabortions preprandially after admittance to the clinic. Anamnesis was followed by routine blood pressure check, then 0.01 mg/kg-1 atropine, 0.1 mg/kg-1 diazepam iv, or 0.05 mg/kg-1 midazolam iv was given to 25 women. 1-2 minutes later 0.5 mg/kg-1 ketamine iv was given, and at the time of insertion of the aspiration cannula into the cervix, another dose of 0.25 mg/kg-1 of ketamine was given iv. The total dose did not exceed 1 mg/kg-1 iv. All patients also received a ketamine-benzodiazepine combination of analgesia prior to the miniabortion procedure. In psychic, unstable women anxiolytic effects were apparent, but in all of them vertigo and the sensation of floating ensued with horizontal and vertical nystagmus, although information could be extracted from them depending on the degree of analgesia. Anterograde amnesia followed, and the systolic and diastolic pressure increased. The maximum duration of analgesic effect was 3-5 minutes, most women became well-oriented without ataxia and returned home 4 hours after the operation. No psychic effects lasted, and nausea or vomiting was minimal. The hallucinogenic effect of ketamine was attributable to the stimulation of the central dopaminergic system, while diazepam (Spofa) influenced the limbic system causing anterograde amnesia. The potential of midazolam-benzodiazepine combination for future sue lies in its very short biological half-life (1.5-2.5 hours) compared with diazepam (24-36 hours).
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PMID:[Analgesia-sedation using ketamine and benzodiazepines in mini-abortion]. 271 9