Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Auditory and vestibular function was monitored in 30 patients treated with netilmicin for urinary tract infection. During and after the treatment, no signs or symptoms appeared that could be ascribed to an ototoxic effect of the drug. Routine acoustico-vestibular tests as well as advanced, objective acoustic tests revealed no signs of impairment of the labyrinth function. Results of highly sensitive vestibular tests in 15 patients including computerized analysis of the nystagmus responses to caloric tests were compared with results obtained from a sample of normal individuals. Some of the results varied significantly more in the netilmicin group than in the reference group. The most characteristic variation was a decreased reaction to hot water stimulation.
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PMID:Netilmicin treatment followed by monitoring of vestibular and auditory function using highly sensitive methods. 697 Sep 82

The authors present a case of an 87-year-old gentleman who presented with general deterioration, increased confusion, recurrent falls and unsteadiness. He was treated for a urinary tract infection but was found to deteriorate rapidly, developing bilateral nystagmus, marked pastpointing, dysarthria and central ataxia. He had a complex medical history including epilepsy controlled with long-term phenytoin. Phenytoin is 90% protein bound and displaced by bilirubin. At the time of deterioration his total phenytoin concentration was within the limits of the laboratory's recommended therapeutic range. The biochemistry report also denoted the patient was hypoalbuminaemic and hyperbilirubinaemic. His symptoms completely resolved with phenytoin dose reduction. The combination of low albumin and high bilirubin may cause an increase in the free phenytoin concentration, resulting in toxicity, despite the measured total phenytoin concentration being within the therapeutic interval.
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PMID:When less is more: a case of phenytoin toxicity. 2353 44