Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 3-year-old boy had a history of nausea and vomiting for 1 month. After two episodes of tonic cramp, he became drowsy and then semicomatous. Physical examination on admission revealed a dehydrated semicomatous boy with fixed, dilated pupils of equal size, horizontal nystagmus, and left hemiparesis with bilateral Babinski signs. Plain skull films showed a separation of coronal and sagittal sutures. A high density area surrounded by cyst was found in the pineal region in CT scan. Angiography demonstrated stretching of the posterior choroidal arteries, backward displacement of the Galen, the posterior mesencephalic and the precentral vein. The right occipital transtentorial approach was selected to remove the tumor totally. Histology revealed epidermis, hair follicle, sebaceus and sweat glands, columar gland, bone, cartilage, muscle, fatty tissue, nervous tissue, and connective tissue, indicating a pineal teratoma. There was no evidence of germinoma.
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PMID:[Pineal teratoma--case report (author's transl)]. 44 May 19

Electronystagmographic (ENG) examination may indicate clinically abnormal but nonspecific or even diagnostically deceptive results. Insights into the processes producing such observations sometimes can be suggested from correlations of findings to pathologic conditions in cases of demonstrated vestibular lesions. Such an opportunity occurred when unusual ENG results were obtained from a patient who had a history of equilibrium disturbances. The ENG revealed a direction-changing nystagmus in lateral head and body positions but not with the head similarly turned. Ocular counterroll measurements indicated hypofunctioning otolithic reactions despite normal vestibuloocular responses to calorizations. Radiologic follow-up showed a midline cerebellar tumor, later surgically confirmed, and found to be a rare teratoma. After partial excision and decompression, repeat tests revealed changes in both the positional nystagmus and ocular counterroll. These findings have implications for diagnosis, for mechanisms underlying ataxia, for inclusion of ocular counterroll testing in diagnostic evaluations, and for understanding the mechanisms underlying direction-changing positional nystagmus.
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PMID:Labyrinthine functional tests and a case of midline cerebellar teratoma. 323 20

Brain tumors are, after leukemias, the most frequent fatal neoplasms of infancy. The clinical features and symptoms are often markedly different from those observed in the adult forms, according to the peculiar anatomy and behaviour of the child. Persistent headache, vomiting, astenia , behavioral alterations may be the precocious findings. Later, some more specific and suggestive signs such as strabismus, dyplopia , fast head size increase, funduscopic alterations, ataxia, paresis and nystagmus may be observed. On their appearance a prompt diagnostic work-up should be performed. The tumors of the posterior fossa (cerebellar astrocytoma and medulloblastoma, brainstem glyoma , hependimoma in decreasing order of frequency) generally cause precocious symptoms because of the small dimension of the subtentorial space; the presence in this region of several fundamental nuclei and pathways may explain how also small tumors may cause severe deficits. Supratentorial tumors (astrocytoma, malignant glyoma , hependimoma , craniofaringioma ) often show a more prolonged latency and may begin with signs of endocranial hypertension, seizures, or sometimes with hormonal troubles according to the involved anatomic structures. Hypothalamic astrocytoma is responsible of an extreme weight loss as far as to a cachetic status, due to the hyperincretion of GH. Finally, plexus papilloma, dermoid, optic nerve glyoma , oligodendroglyoma , germinoma, teratoma are responsible of a small number of child brain tumors, with different localization and symptomatology.
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PMID:[Clinical course of brain tumors in childhood]. 673 95